Background & objectives: Hyperthyroidism is related to expanded food consumption, energy use and modified body synthesis. This study was meant to assess the job of adipocytokines in weight homeostasis in patients with hyperthyroidism. Methods: Patients (n=27, 11men) with hyperthyroidism (20 Graves' sickness, 7 harmful multinodular goitres) with a mean period of 31.3±4.2 years and 28 sound Body Mass Index (BMI) matched controls were examined. They went through an evaluation of Lean Body Mass (LBM) and total muscle to total body fat (TBF) by double energy Xray absorptiometer (DXA) and a blood test was taken in the fasting state for estimation of leptin, adiponectin, ghrelin, insulin, glucose and lipids. Patients were reexamined following 3 months of treatment as at that point every one of them accomplished euthyroid state with carbimazole treatment.