Online ISSN: 2515-8260

Author : Cohrs, Randall J.

Congress Abstracts: 2018-European Clinical Case Reports Congress (EUCCR-2018), 21–22 April 2018, Vienna, Austria

Aamir Shahzad; Randall J. Cohrs

European Journal of Molecular & Clinical Medicine, 2018, Volume 5, Issue 1, Pages 51-84

Oral Abstracts First report of a case of central nervous system vasculitis associated to the use of the check point inhibitor ipilimumab Juan Maya, Florentina Berianu, Benjamin Wang, Andy Abril and Ronald R. Butendieck Jr. Mayo Clinic Florida, Jacksonville, US

Abstracts: 5th Annual Congress of the European Society for Translational Medicine (EUSTM-2017), 20–22 October 2017, Berlin, Germany

Aamir Shahzad; Randall J. Cohrs

European Journal of Molecular & Clinical Medicine, 2017, Volume 4, Issue 1, Pages 48-98

Regenerative medicine is a promising field with the potential to overcome the increasing need for donor organs either by stopping disease progression (e.g. with cells, genes or biologics) or by providing novel organ options. Furthermore, regenerative medicine strategies are unlike other treatments in that they are meant to persevere and treat the underlying injury rather than symptoms. This requires a level of persistence and safety and long term efficacy not always previously required for new therapies. In the past decade, clinicians have been able to utilize cell and gene therapies in unprecedented numbers, but with mixed results. At the same time, scientists have engineered organs (bladder, esophagus and blood vessels) that are considered simple structurally and functionally. However, regenerative medicine is yet to fully succeed with cells or genes or to fabricate fully functional solid organs such as kidneys, livers, lungs, and hearts. Yet, development of organs in the laboratory is proceeding both via 3D printing and use of decellularized scaffolds

The 14th Annual Meeting of the Rocky Mountain Virology Association: Current Advances in Virology and Prion Biology in the Rocky Mountain region

J. Rovnak; Randall J. Cohrs

European Journal of Molecular & Clinical Medicine, 2015, Volume 2, Issue 4, Pages -

The 14th annual meeting of the Rocky Mountain Virology Association was held October 3–5, 2014 at the Colorado State University Mountain Campus in Pingree Park, Colorado. We had classic mountain weather with clear cold starry skies at night and bright warm days. Approximately 80 students, post-docs, and early-stage and established investigators, who perform basic and clinical research, were in attendance. The aims of the program are to bring together regional and national virologists and prion biologists to share and discuss their scientific data and ideas, to foster graduate student education and postdoctoral training, and to help early stage investigators in their career development. This year we instituted a peer review program for student and post-doc presentations in order to provide constructive, written feedback. Poster presenters also had an opportunity to provide 3- minute, single-slide, oral introductions to their work. Our guest speakers, Rich Condit from the University of Florida, Lee Fortunato from the University of Idaho, Cathy Miller from Iowa State University, and Nicole Garneau from the Denver Museum of Nature and Science, all provided inspirational presentations of their research efforts and raised the bar on critical participation in all aspects of the meeting.

Translational Medicine definition by the European Society for Translational Medicine

Randall J. Cohrs; Tyler Martin; Parviz Ghahramani; Luc Bidaut; Paul J. Higgins; Aamir Shahzad

European Journal of Molecular & Clinical Medicine, 2015, Volume 2, Issue 3, Pages 86-88

Progress in the field of translational medicine (TM) within the last decade attests to the importance of the TM initiative in the context of more traditional academic health science centers. In many instances, these advancements have taken place without a clear definition of TM, which signifies the urgent need for a clear, consensus definition that would serve as an integrative blueprint for the various “versions” of TM definition. The various existing definitions are reflecting the diversity of institutional translational research and deployment programs. The European Society for Translational Medicine (EUSTM) is a global non-profit and neutral society whose principal objective is to enhance world-wide healthcare through the specific development and eventual clinical implementation and exploitation of TM-based approaches, resources and expertise. In this position article, the EUSTM defines TM as an interdisciplinary branch of the biomedical field supported by three main pillars: benchside, bedside and community. The goal of TM is to combine disciplines, resources, expertise, and techniques within these pillars to promote enhancements in prevention, diagnosis, and therapies. Accordingly, TM is a highly interdisciplinary field, the primary goal of which is to coalesce assets of various natures within the individual pillars in order to improve the global healthcare system significantly.

Translational medicine and varicella zoster virus: Need for disease modeling

Aamir Shahzad; Don Gilden; Randall J. Cohrs

European Journal of Molecular & Clinical Medicine, 2015, Volume 2, Issue 3, Pages 89-91

VZV is a ubiquitous human pathogen typically encountered early in life when primary infection causes chickenpox. During this time the virus infects ganglionic neurons at all levels of the neuraxis where the virus remains latent in host neurons. The fact that 495% of the world’s inhabitants have an immunologic response to VZV highlights the problem encountered when ascribing disease etiology to VZV reactivation. There are multiple challenges and problems to better understand pathobiology of VZV latency. There is currently no suitable disease model that mirrors the human diseases caused when virus reactivates. Without a disease model, Koch’s postulates cannot be met and ascribing a causal relationship is tenuous. Without a suitable model for all facets of VZV infection, latency and reactivation, understanding of VZV pathobiology will be difficult. Focal points: Benchside Suitable models for all facets of VZV infection, latency and reactivation are required to better understand the mechanism of VZV pathobiology. Governments Due to the increasing number of geriatric population at risk for severe disease caused by varicella zoster virus reactivation, there is immediate need to increase funding for research studies to find suitable models for VZV infection, latency and reactivation.

Rapid salive test for varicella zoster virus

Randall J. Cohrs

European Journal of Molecular & Clinical Medicine, 2015, Volume 2, Issue 2, Pages -

Varicella zoster virus (VZV) is a ubiquitous human herpesvirus typically causing childhood varicella (chickenpox) at which time a life-long latent infection is established in ganglionic neurons throughout the neuraxis. Reactivation of latent virus, typically in the elderly and immunocompetent usually causes zoster (shingles) but can also result in serious neurologic disease. In cases of vasculopathy, meningoencephalitis and myelitis where VZV is suspected, diagnosis requires detection of virus DNA or antibody in CSF. In collaboration with NASA, VZV DNA was found in saliva of health astronauts suggesting asymptomatic virus reaction due to the stress of spaceflight. This lead to a series of studies indicating virus DNA can be found in saliva of patients with VZV associated neurologic disease.