Online ISSN: 2515-8260

Author : Ermilov, Oleg V.

A Rare Example of a Combination of Diffuse Idiopathic Skeletal Hyperostosis and Bronchial Asthma in the Elderly

Andrey Yu. Tretyakov; Oleg V. Ermilov; Nina I. Zhernakova; Sergei A. Shekhovtsov; Victoria A. Tretyakova; Anna V. Ulezko; Alina N. Mishchenko; Maria I. Chervatyuk

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 98-101

Prediction of fatal arrhythmias in acute myocardial infarction (AMI) is extremely
important. Objective: Create a differential diagnostic model for predicting sudden
cardiac death in elderly patients with STEMI with the history of PCI. Methods: We
studied 152 patients (143 men and 9 women), mean age 70.3±3.4 years, with STEMI
after PCI; EF LV less than 50%. The patients were divided into 2 groups: those who
died on the first day from SCD and those who survived. The QT interval and its parts
were measured upon admission and after PCI. The control group consisted of 30
healthy individuals. Results: A model was developed for determining the level of risk of
arrhythmic death on the first day from SCD after successful PCI based on ECG criteria
using DA. The most informative for the differential diagnosis was a set of the following
indicators: QTd, QTapcd, and SubTd. The most significant indicator is Sub Td. The
following algorithms were developed: ROAD = Qtd x 0.3438 + QTapcd x 0.0842 -
SubTd x 0.0864 - 19.5068, NROAD = Qtd x 0.1997 - QTapcd x 0.0148 + SubTd x
0.3261 - 20.893. Their practical implementation on models is proved. Conclusion: The
creation of a “ROAD/NROAD” differential diagnosis model for predicting SCD in
patients with STEMI after PCI suggests practical application at the prehospital stage in
this category of patients for prophylactically fatal VA and SCD. Assessment of the
possible development of adverse events in patients with STEMI after PCI is possible
using the ECG method based on the use of indicators such as QTd, QTapcd, and
SubTd at the prehospital stage.

Features of the Metabolic Syndrome and Type 2 Diabetes Mellitus in Schizotypal Disorder

Oleg V. Ermilov; Andrey Yu. Tretyakov; Lyubov V. Romasenko; Nina I. Zhernakova; Elizaveta S. Rudycheva; Inna V. Tikhonova; Irina A. Misan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 122-127

Objective: To describe the features and mechanisms of development of metabolic
syndrome (MS), type 2 diabetes melitus (DM2) and intermediate states of glycemia in
psychosis the occurrence of these disorders, the values of total cholesterol (TC),
fractions of high density lipoproteins (HDL), very low density lipoproteins (VLDL),
triglycerides (TG), values of atherogenic coefficient (AC), insulinemia, С-peptidemia,
insulin resistance (IR) the level of glycated hemoglobin (HbA1c) in a sample of patients
with schizophrenia and in mentally healthy individuals.
Materials and methods: The frequency of carbohydrate metabolism disorders (CMD) was
studied. Fasting glycemia was determined, and in the presence of its violation, a glucose
tolerance test was performed. MS components were studied in patients with DM2,
plasma concentrations of TC, HDL, VLDL, TG, C-peptide (CP), insulin and HbA1c were
determined in patients with DM2, AC values and IR indices were calculated using
HOMA-IR and CARO criteria.
Results: CMD in schizophrenia are more common than among mentally healthy subjects,
amounting to 13.1% (p=0.02), and the main condition here is a significant number of
individuals with impaired fasting glycemia (IFG) and impaired glucose tolerance (IGT)
among women (CMD p=0.01; IGT p<0.001; IFG p=0.03). A feature of psychiatric
sampling is a decrease in HDL by 16.4% (p=0.03) and an increase in AC by 52%
(p=0.02). Mentally ill men with MS are characterized by a significantly large value of AC
(p=0.019), insulinemia (p=0.02), CP level (p=0.02), HOMA-IR (p=0.01) and CARO
(p=0.04) values than in mentally ill patients with DM2 without MS. In comparison with
the control, regardless of gender, the schizophrenic patients with DM2 have significantly
lower values of insulin (p=0.03), C-peptidemia (p=0.04) and IR, according to the criteria of
HOMA-IR (p=0.01) and CARO (p=0.03).