Online ISSN: 2515-8260

Author : Girish, Kashid


FORMULATION DEVELOPMENT OF MODIFIED RELEASE DOSAGE FORM OF ANTIHYPERTENSIVE DRUG

Raosaheb S Shendge; Kishor S Salunkhe; Kashid Girish

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 4, Pages 2125-2133

Changed delivery dosage structures have been created to deliver drug to the aspect of the body where it will be ingested, to streamline dosing plans, and to guarantee that centralization of drug is kept up over a fitting time interval. Drugs that are not innately dependable require various every day dosing to accomplish the ideal therapeutic impacts. Numerous day by day dosing is regularly badly designed and can bring about missed doses, made-up doses and patient rebellious with therapeutic routine. Blood levels of drugs from conventional prompt delivery dosage structures taken more than once every day following distinct timetable normally demonstrate consecutive pinnacles and troughs (valleys) related with each dose. Intended to deliver their prescription in controlled way, at a pre-decided rate, span and area in the body to accomplish and keep up optimum therapeutic blood levels of drug.

FORMULATION AND EVALUATION OF FAST DISSOLVING SUBLINGUAL FILM OF ANTIHISTAMINE DRUG

Raosaheb S Shendge; Kishor S Salunkhe; Kashid Girish

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 4, Pages 2134-2143

Oral routes are most usually favored course for delivering drug. Most basic oral dosage structures are tablet and capsules. However, numerous patients, for example, geriatric, pediatric and dysphasic patients discover hard to swallow ordinary tablet and case. To conquer different issues identified with gulping, Fast dissolving Tablets (FDTs) were planned in mid nineteenth century and consequently further progression has prompted improvement of Fast Dissolving Oral Films (FDOFs). In the ongoing years, huge numbers of the drug bunches are zeroing in their examination on rapid dissolving innovation. Among the plenty of roads investigated for rapid drug delivering product, FDOFs innovation is increasing a lot of consideration. These are solid dosage structures, which crumble or dissolve inside 1 min when put in the mouth without drinking water or rumination. This innovation has been utilized for neighborhood activity just as rapid delivery products. The fast dissolving oral films are planned utilizing different Active drug fixings (API), film forming polymers, plasticizer, flavors, colors and sweeteners. At first FDOFs are up to breath strips, dessert and oral consideration markets. In any case, presently it turned into a novel and generally acknowledged innovation for delivering OTC and professionally prescribed medication as well.