Online ISSN: 2515-8260

Author : Girija, Smiline


ASSOCIATION OF ACE EXPRESSION AMONG HYPERTENSION PATIENTS IN COVID - 19 PANDEMIC

Akshayaa. L; Smiline Girija; A.S, Ezhilarasan. D

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 186-193

The present review provides valuable information about the ACE expression and its association with hypertension in COVID-19 patients. The potent use of angiotensin converting enzyme inhibitors, found to increase the ACE expression in hypertension and cardiovascular diseased patients which leads to acute lung injury. Currently there is no clear evidence that impact use of ACEI or ARBs could increase the severity of COVID -19 infection in hypertensive patients.COVID -19 being an infectious disease increases the mortality and morbidity of patients with hypertension. Previous studies have been reported that hypertension is considered as a prognostic indicator in SARS nCov infection. Few studies have also reported that there is no significant association of ACE expression with Covid 19. Review data was collected using the recent articles searched from PubMed, the google scholar, core, Cochrane, from 2000 to 2020. The present review highlights all the possible factors between ACE expression among hypertension patients and covid disease.

HANTAVIRUS AND ITS ASSOCIATED IMMUNOPATHOGENESIS

Ananya R; Smiline Girija; Ezhilarasan D

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 2030-2037

Hantavirus is a zoonotic virus manifesting two vital clinical symptoms viz., hemorrhagic fever with renal syndrome and cardiopulmonary syndrome. With a sudden onset of fatigue, fever, and body aches, in extreme cases can lead to shortness of breath and had resulted in major outbreaks in past decades. Pro- inflammatory cytokine responses and reticulo endothelial systems take the lead role in establishing the immuno-pathogenesis of the hantavirus disease. The virus genome consists of these segments of negative stranded RNA, where the large (L) segment encodes the viral RNA polymerase, the medium (M) segment the glycoprotein precursor which is co-translationally cleaved into the envelope glycoproteins Gn and Gc, and the small (S) segment the nucleocapsid protein (N). Hantavirus are divided into Old world and New world hantavirus based on the geographic regions in which they occur. They are strictly associated with their reservoirs hosts which are rodents, but from recent researches reported, also insectivores. Both innate and cellular immune responses function effectively in evading the viral replication, however the mutations and the typical variations in the virus finally establishes a disease in humans. This review thus provides an overview on hanta virus and its associated immune-pathogenesis.