Online ISSN: 2515-8260

Author : A.S, Smiline Girija


Recommended Medications For N- Cov Disease - A Review.

Dhayanithi. J; Smiline Girija A.S; Brundha M.P

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 2572-2582

With the raising concerns on the mortality rate in the recent covid pandemic, the lacunae of proper treatment strategy plays a vital factor. Since there is no approved medication for COVID-19, medications involving hydroxychloroquine sulfate and chloroquine phosphate were recently recommended. The National Medical Products Administration of China has approved Favilavir, an antiviral medication, with minimal side effects and a moderate control on viral replication. Remdesvir, another antiviral, has drawn the attention of several researchers to treat the novel COVID-19 virus as COVID-19 is identical to SARS and MERS viruses. Remdesvir, was successful in the previous outbreaks of SARS and MERS. Some researchers also suggest high doses of vitamin C supplementation may improve the patient''s condition. This review thus provides a basic overview on the recommended medication and urges the need to develop novel anti-covid drugs and vaccines.

Molecular Diagnostic Methods For Viral Infections

Dhakshinya M; Smiline Girija A.S; Ezhilarasan D

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 2595-2605

Viral diagnostic tests are categorized as direct diagnosis, indirect examination (virus isolation), and serology. Molecular testing is often done to detect potent viral markers resulting from any gene or chromosomal modifications during viral replication in the host. The clinical specimen is tested specifically in direct analysis for the presence of virus particles, virus antigens or viral nucleic acids. Molecular diagnosis of viruses can be achieved from clinical samples like blood, hair, skin, amniotic fluid, or other tissue. Molecular biology techniques are considered to be the standard and confirmatory protocols in the analysis of viral DNA, RNA and protein. Molecular viral diagnosis are considered to be more specific and sensitive in preliminary viral screening and can pave the way for rapid diagnosis. However, the procedures are costly and involve automated bio-instruments to perform the same. This review thus highlights the various molecular diagnostic methods used in diagnostic virology with their limitations and challenges.