Author : Ali, Dr Syed Sabir
Astudy to Compare the Analgesic Efficacy of Intra-Articular Levobupivacaine, Fentanyl And Clonidine Following Arthroscopic Knee Surgery
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 6, Pages 1160-1165
Arthroscopic knee surgery can produce pain postoperativelywhich can be very distressing. Many drugs in variousways have been tried to overcomethis pain. But none found to be most effective.So we have done a study for correlating with the analgesiclevobupivacaine efficiency, fentanyl, & clonidine into intra-articular therapy associated with arthroscopic surgeries. This study was conducted from Nov 2019 to April 2020, in which 90 patients undergoing arthroscopicsurgery of knee split in 3classes of 30 each. (L,F,C). ClassL were injected 10 millilitrein levobupivacaine of 0.26% e, where ClassF wereinjected 50 mcg fentanyl, and Class Cwere injected 50 mcg of clonidine in intra-articular therapyafter surgery. Time of first analgesia request, no of analgesic dose required and total rescue analgesic required in postoperative 24 hours were assessed. Pain was assessed using visual analogue scale. Demographic characteristicsweresimilaramong allthe three Classs. Time for need of 1stanalgesic request in ClassL was 381.57 ± 24.63 min, in ClassF was 328.67 ± 20.42 min and in Class C was 238.47 ± 21.93 minutes.(p<0.06)Overall amount ofdoses of analgesic needed was fewer in ClassL (1.21 ± 0.57) in comparison to ClassF (1.95 ± 0.42) and Class C (2.12 ± 0.34). (p<0.05) Total dose of paracetamol used was reduced in ClassLcorrelated withClassF and C in 1st 24 hrs postoperatively. (p<0.05) Class F & C has highest average score of VAS at various time points in 1st 24 hrs correlated withClass L.(p<0.05) Intra-articular levobupivacaine obtained better control of pain inpostoperative period with delayed time of need of 1st analgesicdose and reduced the need of total dose of rescue analgesicin comparison to intra-articular clonidineandfentanyl.