European Journal of Molecular & Clinical Medicine

BACKGROUND: A major health problem is hypertension during pregnancy. This complicates In India, around 5 to 10 percent of pregnancies occur. Preeclampsia is a disorder whose pathogenesis is still not clearly understood. One theory suggested that the cause of PE is, endothelial dysfunction is brought about by certain factors released from ischemic placenta leading to poor uterine and placental perfusion. Preliminary executive research suggests that serum LDH and uric acid are abnormal in women with preeclampsia-eclampsia and usual in women with normotension. AIM AND OBJECTIVES: We aim to study the correlation between serum lactate dehydrogenase levels and serum uric acid levels in in normotensive pregnant women and preeclamptic-eclamptic pregnant women together with their feto-maternal performance. The objectives of the study to compare and correlate serum lactate dehydrogenase and serum uric acid levels in normotensive and preeclamptic-eclamptic women with feto-maternal outcome. MATERIALS AND METHODS: This is a prospective observational study and will be conducted in the obstetrics and gynaecology department, AVBRH, DMIMS (Deemed to be University, Wardha), situated in the rural area of Wardha district in over 230 patients for period between 2020-23. This study will include antenatal patients of age 18 - 35yrs, gestation 28-40 weeks, normotensive and preeclampsia-eclampsia women and will exclude mothers with hypertension < 20 weeks of gestation (Chronic Hypertension), multiple pregnancy, pre-existing Diabetes Mellitus, liver disorder, renal disorder, epileptic disorder, thyroid disorder, Heart Disease, leukaemia, haemolysis and hepatitis. EXPECTED RESULTS: We expect that there will be significant difference in maternal and fetal outcome based on serum lactate dehydrogenase and serum uric acid concentration in normotensive and preeclamptic -eclamptic pregnant women.

Background: Preterm labour is a pressing public health issue. Currently, nearly one tenth of all the pregnancies are preterm, contributing to ~ 80% of neonatal morbidity and mortality. Although, preterm labour is defined as labour < 37 completed weeks, practically birth after 34 weeks of gestation have better survival outcomes. Tocolytics are the mainstay of reducing preterm deliveries. They cause partial uterine relaxation and hence help in prolonging the pregnancy for at least for 48 - 72 hrs, thus providing sufficient time for corticosteroids to aid in maturation of lungs; thereby preventing respiratory distress syndrome. While there are quite a few tocolytics available, most of them require close fetomaternal monitoring due to their adverse effects. Currently, nifedipine is tocolytic of choice. Nitroglycerine, which is rapidly metabolized in liver has fewer side effects and its transdermal use is beneficial due to its convenience of usage. Since there are very few studies documenting the comparison of the two drugs, our study will be beneficial.
Objectives: To study and compare the effectiveness of transdermal Nitroglycerine patch and oral nifedipine.
Methodology: This study will include a total of 130 women in preterm labour fulfilling the inclusion and exclusion criteria. These study subjects will be divided into two groups A and B randomly using envelope method. One group will be given transdermal nitroglycerine patch and the other will be given oral nifedipine as a tocolytic agent to reduce the preterm contractions. Treatment will be considered successful if contractions stopped and no recurrence of contractions occurred within or after 48 hours. 
Expected results: Transdermal Nitroglycerine patch is more effective than oral nifedipine in management of preterm labour.
Conclusion: Transdermal nitroglycerine patch is more effective in prolonging the pregnancy as compared to oral nifedipine with less adverse effects.