Author : Aggrawal, Sachin
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 11, Pages 3816-3822
Background: Near normal electrolyte, acid-base status is usually is maintained in a compensated state of cirrhotic patient, however this can disrupted by unwellness progression, infection, dietary indiscretion/deprivation, or medical specialty intervention. Many mineral metabolism disorders are related with hepatic diseases; however, their etiology, complication is nevertheless to be known. Synthesis of these compounds occurs mainly in the liver. In recent years, studies of minerals in liver diseases have been of considerable interest.
Aim: To estimate the levels of Sodium, Potassium and Calcium in Cirrhosis of Liver.
1. To correlate the levels of Sodium, Potassium and Calcium with in-hospital morbidity and mortality in patients of cirrhosis.
2. To correlate the levels of Sodium, Potassium and Calcium with the Severity of Disease.
Material and Methods: This cross-sectional study is going to be conducted within Department of medication, at AVBRH, a tertiary care teaching hospital settled within the geographical region of Wardha District among fifty patients > eighteen years older despite
gender or quality. Careful history and examination of the patients are going to be undertaken. Baseline information like age, sex, explanation for liver disease, ascites, hepatic encephalopathy, and routine laboratory information are going to be collected. Grade of ascites and hepatic encephalopathy, are going to be established consistent with the relevant criteria. The laboratory information primarily can embrace red corpuscle count, white corpuscle count, total bilirubin, hemoglobin, direct bilirubin, albumin, indirect bilirubin, alanine aminotransferase, alkaline phosphatase, creatinine, aspartate aminotransferase, platelet count, gamma-glutamyl transpeptidase, blood urea nitrogen, activated partial thromboplastin time, prothrombin time, international normalized ratio, Na, K and Ca.
Expected Results: We expect from our results that higher body fluid Na, potassium and calcium concentrations are completely related to inflated in-hospital mortality in patients of cirrhosis.