Online ISSN: 2515-8260

Author : Ahmad, Rizwan


SYNTHESIS OF REMARKABLE SUBSTITUTED ARYL 1,3,4-OXADIAZOLE DERIVATIVES AND THEIR POTENT ANTIINFLAMMATORY AND ANALGESIC ACTIVITIES

Vishal kumar; Satish Kumar Sharma; Rizwan Ahmad

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 4406-4415

The key objective of the current research is to synthesize and analgesic action 5- (2-(2,3-dimethylphenylamino)phenyl)-2-(aryl)- 1,3,4-oxadiazole and to test this activity (VT1- VT8). During this investigation, the condensed methanone {2-[(2,3- dimethylphenyl)amino]phenyl}(hydrazinyloxide), and various aryl-acids in presence of phosphorous oxychloride were synthesized in the present investigations by a sequence of 5-(2- (2,3-dimethylphenylamino)phenyl]-2,3,4-oxadiazols (VT1-VT8). Both synthesized compounds have been tested with 50 mg/kg and 10 mg/kg po respectively for their in vivo antiinflammatory and analgesic activities. Carrageen's mediated acute rat paw oedema model and Eddy's hot plate system were used to analyze the anti-inflammatory and analgesic function of the synthesized compounds. Any substances have been effective at their anti-inflammatory and analgesic activities, according to biological results. Elemental research (C, H, N) and spectral analysis also verified the composition of both substances (IR, 1H NMR and mass spectrometry).