Online ISSN: 2515-8260

Author : Abhimanyu Kumarc, Md Tanweer Alama, Rajeev Pradhanb,

Molecular docking studies and theoretical investigation of anti-novel corona activity of chloroquine and its derivatives

Md Tanweer Alama, Rajeev Pradhanb, Abhimanyu Kumarc

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 706-711

In quest of some anti-Novel corona activity  drugs, molecular docking studies with
PDB ID 6LU7  were carried out using certain well known chloroquine and its  derivatives viz  Hydroxychloroquine  Mefloquine. Molecular docking has been done in order to search the best drug candidate among chloroquine derivatives. The molecular dockings were done in Argus lab. Molecular docking studies revealed that chloroquine found effectively inhibit the recently emerged novel coronavirus . The docking score for chloroquine, Hydroxychloroquine  Mefloquine found to be -8.55665, -8.30357, -7.98409 respectively. Chloroquine  is found to be best drug candidate among its derivatives with docking score of  -8.55665.