Online ISSN: 2515-8260

Author : Abdelghany, Tamer Muhammed Moustafa


Contrast-Induced Nephropathy: a comprehensive review

Kamel Hassan Ghazal; Tamer Muhammed Moustafa Abdelghany; Khaled Muhammed Souliman Hamed; Ahmed Said Eldamahoury

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2169-2180

Contrast-induced nephropathy (CIN) is defined as the impairment of renal function
measured as either a 25% increase in serum creatinine (SCr) from baseline or a 0.5
mg/dL (44 μmol/L) increase in absolute SCr value within 48-72 hours after
intravenous contrast administration. Although prophylactic hydration has been
promising in decreasing the occurrence of CIN, other efforts such as diuretics,
calcium channel blockers, theophylline, aminophylline, atrial natriuretic peptide,
dopamine, and fenoldopam have been disappointing. The preventive effect of Nacetylcysteine
on CIN has not been consistent in the literature. In a recent clinical
trial, bicarbonate infusion was more effective than hydration in the prevention of
CIN. Mechanical devices are in development to perfuse renal arteries with
protective drugs during contrast exposure or for removal of contrast from coronary
sinus during coronary angiography. In this article, we have reviewed available data
in regards to CIN.

Contrast-Induced Nephropathy: a comprehensive review.

Kamel Hassan Ghazal; Tamer Muhammed Moustafa Abdelghany; Khaled Muhammed Souliman Hamed; Ahmed Said Eldamahoury

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2169-2180

Contrast-induced nephropathy (CIN) is defined as the impairment of renal function
measured as either a 25% increase in serum creatinine (SCr) from baseline or a 0.5
mg/dL (44 μmol/L) increase in absolute SCr value within 48-72 hours after
intravenous contrast administration. Although prophylactic hydration has been
promising in decreasing the occurrence of CIN, other efforts such as diuretics,
calcium channel blockers, theophylline, aminophylline, atrial natriuretic peptide,
dopamine, and fenoldopam have been disappointing. The preventive effect of Nacetylcysteine
on CIN has not been consistent in the literature. In a recent clinical
trial, bicarbonate infusion was more effective than hydration in the prevention of
CIN. Mechanical devices are in development to perfuse renal arteries with
protective drugs during contrast exposure or for removal of contrast from coronary
sinus during coronary angiography. In this article, we have reviewed available data
in regards to CIN.

Blood urea nitrogen to left ventricular ejection fraction ratio and TIMI risk index as predictors for contrast- induced nephropathy in patients with acute coronary syndrome

Kamel Hassan Ghazal; Tamer Muhammed Moustafa Abdelghany; Khaled Muhammed Souliman Hamed; Ahmed Said Eldamahoury

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 2615-2626

Background: Acute coronary syndrome (ACS) refers to a spectrum of clinical
presentations ranging from those for ST-segment elevation myocardial infarction
(STEMI) to presentations found in non–ST-segment elevation myocardial infarction
(NSTEMI) or in unstable angina. Contrast-induced nephropathy (CIN) is defined as the
impairment of renal function-measured as either a 25% increase in serum creatinine
(SCr) from baseline or a 0.5 mg/dL (44 μmol/L) increase in absolute SCr value—within
48-72 hours after intravenous contrast administration.
Objective: To evaluate blood urea nitrogen to left ventricular ejection ratio and TIMI risk
index as predictors for occurrence of CIN in patients with acute coronary syndrome who
underwent PCI.