Online ISSN: 2515-8260

Author : Ahmed, Mohamed Fouad Mostafa


Role of Endoscopic Ultrasound in Diagnosis of Pancreatic Cystic Lesions in Comparison to Computed Topography and Magnetic Resonance Imaging

Mohamed Fouad Mostafa Ahmed; Walid Ahmady Abd El-Dayem; Talaat Fathy Aly; Mohamed Ibrahim Magdy; Mohamed Ali El-Nady

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2500-2509

Background and aims:To evaluate the advantages of endoscopic ultrasound (EUS) in the
assessment of detailed structures of pancreatic cystic lesions (PCLs) compared to computed
tomography (CT) and magnetic resonance imaging (MRI).
Methods: This prospective cohort study was conducted in Tropical medicine department,
Zagazig university hospitals and in Internal medicine department at Kasr Al Aini Hospitals,
Cairo University, in the period between March 2018 and March 2020. The study included 72
patients with PCLs, 29 were males and 43 were females, there ages ranged from 25 to 75 years.
All cases were subjected to the following careful history taking, thorough clinical examination,
laboratory investigations (CBC, LFTs, KFTs, Coagulation profile, serum amylase, serum CA
19.9), imaging (CT and/or MRI abdomen), endoscopic ultrasound examination and EUS-FNA
biopsies using the 22G or 19G needle.
Results:Validity of abdominal CT/MRI imaging, EUS, cytopathology and EUS with
cytopathology was calculated using diagnostic performance depend on sample 2x2 contingency
tables generation. Sensitivity, specificity, PPV, NPV and accuracy and their corresponding 95%
CI were calculated. P-value < 0.05 was considered statistically significant, p-value < 0.001 was
considered highly statistically significant, and p-value ≥ 0.05 was considered statistically
insignificant.

Pancreatic Cystic Lesions: New Diagnostic Strategies

Mohamed Fouad Mostafa Ahmed; Walid Ahmady Abd El-Dayem; Talaat Fathy Aly; Mohamed Ibrahim Magdy; Mohamed Ali El-Nady

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2510-2525

Pancreatic cystic neoplasms (PCN) are a heterogeneous group of pancreatic cysts that include
intraductal papillary mucinous neoplasms, mucinous cystic neoplasms, serous cystic neoplasms
and other rare cystic lesions, all with different biological behaviors and variable risk of
progression to malignancy. As more pancreatic cysts are incidentally discovered on routine
cross-sectional imaging, optimal surveillance for patients with PCN is becoming an
increasingly common clinical problem, highlighting the need to balance cancer prevention with
the risk of (surgical) overtreatment. This Review summarizes the latest developments in the
diagnosis and management of PCN, including the quality of available evidence. Also discussed
are the most important differences between the PCN guidelines from the American
Gastroenterological Association, the International Association of Pancreatology and the
European Study Group on Cystic Tumors of the Pancreas, including diagnostic and follow-up
strategies and indications for surgery. Finally, new developments in the management of patients
with PCN are addressed.