Online ISSN: 2515-8260

Author : A, Dr. Hemalatha


ADAPTATIONS OF SKELETAL MUSCLE IN AGING RATS: COMBINED INTERVENTION OF AN ANTIOXIDANT-BASED FOOD SUPPLEMENT AND PHYSICAL ACTIVITY

Dr. Hemalatha A

European Journal of Molecular & Clinical Medicine, 2018, Volume 5, Issue 1, Pages 226-232

Physical training has always remained a suitable intervention to overcome the muscle degenerative situations such as sarcopenia not only in the old but also in late-adult and middle-age. This study is aimed to investigate the intervention of physical activity and naturally occurring biologically active compounds of medicinal value in addressing age related skeletal muscle changes. Basella albaalso known as Indian spinach has antiulcer potential, anti-inflammatory activity and hypo-glycemic activity, a natural antioxidant can offer better defense against age related changes in the supplemented physical trained rats. Rats were categorized into four sub-groups. Sedentary control, SE-C; sedentary supplemented, SE-C(S); swim trainees at thermo neutral temperature, SW-T(N) and supplemented swim trainees at thermo neutral temperature, SW-T(N+S). The results suggest that swimming is capable of improving skeletal muscle endurance and mass.  Basella alba supplementation ameliorates the benefits of swim exercise.Basella alba and swim training showed changes and increase in the endurance capacity of skeletal muscles.
 
Keywords: basella alba, extensor digitorum longus,gastrocnemius, soleus,physical activity.

EFFECT OF AN ANTIOXIDANT-BASED FOOD SUPPLEMENT AND PHYSICAL ACTIVITY ON HAEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN AGING RATS

Dr. Hemalatha A

European Journal of Molecular & Clinical Medicine, 2018, Volume 5, Issue 1, Pages 233-239

Basella alba  has hypo-glycemic activity. The present study evaluated the benefits of the natural antioxidant, Basella alba, in treating the effect of age-related oxidative stress. Male Wistarrats of 3- , 12- and 18-months of age received a daily oral supplement of Basella alba for a period of 3 months.  At the end of this period, markers of oxidative stress were assessed in the erythrocytes. Basella alba lowered oxidative stress in erthrocytes. These results demonstrated the antioxidant activity of Basella alba probably confers the capacity to reduce oxidative stress in erythrocytes of aging rats. They also suggest a critical role for Basellain reducing blood glucose level and better haemoglobin content.
Keywords: aging,antioxidant, basella alba, erythrocytes, haemoglobin, haematocrit.