Online ISSN: 2515-8260

Author : Abdullah, Dr Saima Gayas, Dr Aasif


ASSESSMENT OF MATERNAL THYROID HYPOFUNCTION AND PREGNANCY OUTCOME

Dr Saima Gayas, Dr Aasif Abdullah

European Journal of Molecular & Clinical Medicine, 2017, Volume 4, Issue 1, Pages 298-303

Background: Obstetric factors may be responsible for some of the differences in neurologic outcomes seen in the offspring of women with maternal thyroid hypofunction compared with their euthyroid counterparts.
Materials & Methods: 80pregnant women with hypothyroidism were subjected to assessment of thyroid profile that includes T3, T4, TSH, and anti-TPO antibody was performed. Pregnancy outcome was recorded.
Results: There were 25 cases of subclinical hypothyroidism in first trimester and 20 in second trimester. 8 cases of Hypothyroxinemia in first and 7 in second trimester. Overt hypothyroid was seen in 10 in first and 6 in second trimester. There were 5 cases in first and 4 cases in second of euthyroid. The mean parity was 1.2, 1.7, 1.1 and 1.0 in subclinical hypothyroidism, hypothyroxinemia, overt hypothyroid and euthyroid respectively. The mean BMI (Kg/m2) was 24.3, 27.8, 26.8 and 24.1. There were current smokersie. 4, 3, 1 and 5 and prior pregnancy was seen in 5, 4, 2 and 1 in subclinical hypothyroidism, hypothyroxinemia, overt hypothyroid and euthyroid respectively. Maximum cases of miscarriage (2) were seen in subclinical hypothyroidism and gestational hypertension (5) in overt hypothyroidism. Pre- eclampsia (1) was seen in subclinical and overt hypothyroid, pre- term PROM (3) hypothyroxinemia, pre- term labor (2) in subclinical hypothyroidism and 5 cases of gestational diabetes mellitus was seen in hypothyroxinemia.
Conclusion: Overt hypothyroidism in pregnancy is detrimental to the developing fetal brain. Pregnancy outcome showed cases of miscarriage, pre- eclampsia, pre- term PROM, pre- term labor and GDM.

EVALUATION OF PROLACTIN, FSH, LH HORMONES IN FEMALE INFERTILITY

Dr Saima Gayas, Dr Aasif Abdullah

European Journal of Molecular & Clinical Medicine, 2017, Volume 4, Issue 1, Pages 304-308

Background:Infertility is one of the most significant problems in gynaecology. The present study was evaluated FSH, LH and prolactin hormones in female infertility.
Materials & Methods: 72 females with infertility were enrolled in group I and age matched healthy controls were included in group II. The levels of serum follicle stimulating hormone (FSH), luteinizing hormone (LH), and prolactin were measured with enzyme-linked immune-sorbet assay (ELISA) methods.
Results: Age group 20-30 years had 20, 30-40 years had 30 and 40-50 years had 22 subjects. The difference was non- significant (P> 0.05). The mean prolactin level was 18.1 ng/ml in group I and 12.5 ng/ml in group II. FSH level was 8.6 mIU/ml in group I and 6.1 mIU/ml in group II. LH level was 7.9 mIU/ml in group I and 5.8 mIU/ml in group II. The difference was significant (P< 0.05).
Conclusion: Infertile females exhibited higher prolactin, follicle stimulating hormone (FSH) and luteinizing hormone (LH)as compared to healthy females.