Author : Agarwal, Dr. Disha Parhi, Dr. Ankur Garg, Dr. Akash Gupta, Dr. Tulika Mittal, Dr. Neeharika Arora, Dr. Malti
COMPARISON OF FENTANYL AND CLONIDINE AS ADJUVANTS TO INTRATHECAL 1% CHLOROPROCAINE IN INFRA-UMBILICAL SURGERIES
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 4, Pages 3005-3016
Introduction: Spinal anaesthesia is a safe, reliable, inexpensive anaesthetic technique for regional anaesthesia. It also allows early ambulation and early rates of hospital discharges.
Material and methods: Present study was carried at tertiary care Hospital. After receiving ethical approval from the college ethical committee and CTRI registration, 64 patients aged 19 to 65 years old with ASA grade I and II physical status who were undergoing elective infra-umbilical surgeries were included in the study. Patients were randomly allocated in two groups of 32 patients each. Group C: Received 1% Isobaric Chloroprocaine 3 ml (30mg) + clonidine (30 mcg). Group F: Received 1% chloroprocaine 3ml (30 mg) + fentanyl (25 mcg). Total volume = 3.5ml. Sensory block was examined using pin prick method. Quality of motor block was examined and graded using Modified Bromage Scoring. Hemodynamic was monitored and side effects were noted.
Result: Total 64 patients were divided into two groups of 32 each. There were 17 males and 15 females in Group F. While in Group C, male and female participants were 16 each. In group F, mean onset time of sensory blockade was (3.69 ± 0.41min) and mean onset of motor blockade was (5.14 ± 0.65min). In group C, mean onset time of sensory blockade was (3.86 ± 0.28min) and mean onset of motor blockade was (5.31 ± 0.63min). In group F, mean duration of sensory blockade was (74.19 ± 3.14min) and mean duration of motor blockade was (60.24 ± 2.97min). In group C, mean duration of sensory blockade was (110.34 ± 8.45min) and mean duration of motor blockade was (94.88 ± 4.39min). In group F, 1 patient had hypotension and bradycardia while in group C,4 patients had hypotension and 3 had bradycardia. Transient neurological symptoms, respiratory depression and pruritis were not seen in any of the groups.
Conclusion: From our study we conclude that, clonidine as an adjuvant to intrathecal chloroprocaine can be used for infra-umbilical ambulatory surgeries with good sub-arachnoid block quality and lesser side effects.