European Journal of Molecular & Clinical Medicine

Background: Thyroid hormones are essential for normal skeletal development and normal bone metabolism in adults but can have detrimental effects on bone structures in states of thyroid dysfunction. Present study was aimed to study thyroid disorders in relation to bone biochemical parameters (Serum calcium, Serum phosphorus, serum ALP & vitamin D) at a tertiary care hospital.
Material and Methods: Present study was single-center, cross sectional, observational study, conducted in patients with thyroid disorders, 18-70 years age, visiting Medicine OPD for their regular thyroid check-up, underwent estimation of thyroid hormones profile (TSH, T4, T3, serum calcium, serum phosphorus, serum ALP & vitamin D.
Results: In present study 300 patients, majority were from 36-45 years (47.67 %), female (71 %) and had co-morbidities as diabetes mellites (18 %), hypertension (29.67 %). Majority were euthyroid (38 %) while others were Hypothyroid (28 %), Subclinical Hypothyroid (20 %) & Hyperthyroid (14 %). Serum calcium levels in euthyroid patients (8.634 ± 0.711mg/dl) were more than that of hypothyroid patients (8.125 ± 0.838 mg/dl ), Subclinical Hypothyroid patients (7.760 ± 00.81mg /dl) & Hyperthyroid patients (8.10 ± 1.213 mg/ dl ), difference was statistically highly significant (p- 0.001). Serum phosphorus levels in euthyroid patients (3.634 ± 0.421 mg/dl) were less than that in Hypothyroid patients (3.80 ± 0.854 mg /dl), Subclinical Hypothyroid patients (3.690 ± 0.422 mg/ dl ) & Hyperthyroid patients (4.021 ± 0.698g /dl), difference was statistically significant (p- 0.004). Serum ALP levels in euthyroid patients (112 ± 39.806 mg/dl) were less than that of hypothyroid patients (138.143 ± 86.695 mg /dl) & more than levels in Subclinical Hypothyroid patients (94.90 ± 15.442 mg/dl) & Hyperthyroid patients (106.143 ± 31.749 mg/dl), difference was statistically highly significant (p- 0.001). Conclusion: All patients with various thyroid disorders should be periodically evaluated for bone biochemical parameters (Serum calcium, Serum phosphorus, serum ALP & vitamin D) for early diagnosis of bone related disorders and0 to decide treatment protocol.