Online ISSN: 2515-8260

Author : Adiga, Usha

Salivary Metabolomics As Markers Of Progression, Prognosis And Effectiveness Of Therapy In Oral Leukoplakia And Oral Cancer: A Review

Usha Adiga

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 9061-9067

The overall goal of the review is to discuss about establishing a panel of salivary metabolomics markers which may be useful as a non-invasive prognostic markers of oral precancerous and cancerous conditions. The non-invasive panel of salivary metabolomics may be unique in predicting the prognosis of oral pre-cancer and cancerous states, progression of the disease states as well as the effectiveness of treatment. A future researchstudy may be planned to develop a panel of salivary metabolomics for predicting the prognosis of oral leukoplakia as well as oral cancer. It may also predict association of salivary metabolomics with the treatment effectiveness oral cancer.
A non-invasive and cost-effective salivary metabolomic parameters may be developed for predicting the prognosis of oral leukoplakia and oral cancer. Sensitivity, specificity and predictive values of salivary metabolomics panel may be compared as routine histopathology in predicting the transformation of precancerous to cancer may be established

A Randomized Control Study To Evaluate The Influence Of Autogenic Training And To Establish A Non-Invasive Biomarker Pannel For Psoariasis

Usha Adiga

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 9054-9060

Psoriasis is one of the main dermatological disorders caused by stress. It is important to consider a psychological treatment in parallel to the dermatological treatment Hence we aim to  evaluate whether autogenic training is helpful in treating psoriasis as assessed by perceived stress score (PSS),establish a non-invasive panel of biomarkers (salivary versus blood) which may be useful in predicting the disease severity and effectiveness of the therapy in psoriasis. Hundred patients of moderate and severe chronic plaque psoriasis defined as PASI >6 or DLQI >6 , more than 15 years of age will be recruited in this randomized controlled study. Daily autogenic training sessions will be conducted for a week followed by a psycho-education session. Blood samples will be collected to measure the biomarkers using ELISA Technique. Saliva will be collected for the quantification of genetic markers using RT-PCR, miRNA22 BY Real Time PCR-qPCR and whole genome sequencing using Next generation sequencing. Statistical analysis will be carried out using SPSS version 23.
psoarisis, autogenic training, genetics