Online ISSN: 2515-8260

Author : Alagesan, Jagatheesan


Neurodevelopmental Outcome Of Very Preterm And Moderate To Late Preterm Babies At The Corrected Age Of First Year

Alice Jeba; Prathap Suganthirababu; Shivaprakash Sosale; Jagatheesan Alagesan; Vignesh Srinivasan; Nivya Sebastian

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 280-290

Background: Preterm newborns are more prone to exhibit neurodevelopmental delays than neonates born at full term gestational age. The aim of this study was to examine the gross motor, fine motor, personal-social, and language development of severely preterm and moderate-to-late preterm infants at one year of age.
Methods: A randomised controlled study with concealed allocation and blinded outcome assessment was done in a tertiary care neonatal centre in Bangalore, India, from May 2019 to November 2020. The early intervention group included 50 preterm infants born between 28 and 37 weeks gestational age, while the control group included 50 preterm newborns. Premature children with known congenital disorders that affect neurodevelopment were excluded from the study.

Fluctuating asymmetry of dermatoglyphics and the lifetime estrogen exposure in breast cancer risk – an epigenetic perspective

Lavanya Prathap; Prathap Suganthirababu; Kumaresan A; Vignesh Srinivasan; Jagatheesan Alagesan; Deepthi Ganesan

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 491-499

Background: Through an epigenetic mechanism, a woman's total lifetime oestrogen exposure accumulates changes in her DNA methylation pattern. These changes can influence the developing fetus and the resulting epigenetic aberrations is said to be reflected in the dermatoglyphic patterns.  Fluctuating asymmetry (FA) is the difference of dermatoglyphic patterns between the right and left hand. Aim: To explore the association of FA of dermatoglyphics with the reproductive factors in an epigenetic perspective to identify breast cancer risk. Methods: The participants are grouped into three based on the selection criteria as a breast cancer, high risk and control group. The data are collected through digital photographic images. The variables include FA of the finger ridge count (FRC) of Thumb, Ring Finger, and the A-B Ridge Count. The variables of reproductive factors includes increased menstrual age, Nulliparity and first full-term pregnancy >30yrs, and Positive Family History.  Result: Among the reproductive factors involved in the study, The FA thumb is strongly associated with increased menstrual age, FA ring finger is strongly associated with nulliparity and FA subtotal ridge count is observed to be strongly associated with increased menstrual age at significance level of p<0.0001. Age at first full term pregnancy is not significantly associated with any of the dermatoglyphic variables Positive family history is significantly associated with all the dermatoglyphic variable with p<0.0001.Conclusion: FA of dermatoglyphics aids to identify the in-utero epigenetic aberrations of a females linked to breast cancer risk.

The Impact Of Clinical Pilate Exercise On Balance And Functional Mobility In Idiopathic Parkinson Disease Patients: A Case Study

Pavithra S; Kumaresan A; Jagatheesan Alagesan; Aravind Ganesh

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 379-385

Physiotherapy has been recommended for a 68-year-old retired farmer (female) who has been diagnosed as initial idiopathic Parkinson's disease. A summary of the major outcomes is included in the case study, as well as documentation of her intake assessment through a 5-week follow

Tibialis Posterior Muscle Endurance among Physiotherapist with Flatfoot - An Observational Study

Goutham V; Ramana K; Jagatheesan Alagesan; Prathap Suganthirababu; Aravind Ganesh; Rajesh G

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 425-432

Background: The flattening of the foot's medial arch is known as acquired flatfoot. It's one of the most common problems seen among adult health-care providers.
 
Objective: The purpose of this study is to determine the tibialis posterior muscle endurance among physiotherapist with flatfoot.
 
Methodology: The observational study included 60 physiotherapists who met the inclusion criteria. The single legged heel rise test and the foot posture index were used to evaluate each individual with flatfoot.
 
Result: Normal BMI participants had an average of 23.9333 repetitions in their dominant leg and 23 repetitions in their non dominant leg, overweight participants had an average of 15.2857 repetitions in their dominant leg and 14.1071 repetitions in their non dominant leg, and obese participants had an average of 7.11765 repetitions in their dominant leg and 6.17647 repetitions in their non dominant leg in a single legged heel rise test.
 
Conclusion: Participants with flatfoot and a BMI of Overweight, Obese had lower tibialis posterior muscle endurance than flatfoot people with a normal BMI, and the participants had higher tibialis posterior muscle endurance in their dominant leg than in their non dominant leg, according to the findings. 

Qualitative and Quantitative Dermatoglyphics and the Estrogen Exposure in Breast Cancer Risk: an Epigenetic Context.

Lavanya Prathap; Prathap Suganthirababu; Kumaresan A; Vignesh Srinivasan; Jagatheesan Alagesan

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 480-490

Background – The lastingness of dermatoglyphics suggest epidermal ridges as a bio-signature for studying the epigenetic insults in the prenatal period. Approaching the preventive measures in epigenetic viewpoint aid to reduce the incidence of carcinoma.  Objective – To inquire the association of qualitative and quantitative dermatoglyphics and the estrogen exposure in spotting out breast cancer risk in an epigenetic context. Materials and Methods – We performed the study among 150 females in three groups. The outcome of dermatoglyphic variables includes six or more whorls, Mean finger ridge count, A- B Subtotal ridge count, ATD angle and pattern intensity index. The variables of reproductive and genetic factors are increased menstrual age, Nulliparity, First Full Term Pregnancy >30yrs, and Positive Family History. The statistical procedure used are odds ratio and the level of significance using P- value. Results - Increased menstrual age is significantly associated with six and more whorls (P<0.0001), Mean finger ridge count (P<0.04), A-B Ridge count (P<0.0001), ATD angle (P<0.0001), Pattern intensity index (<0.0001). Nulliparity is significantly associated with the ridge count (P<0.0001), ATD angle (P<0.001), full term pregnancy >30yrs is associated significantly with A-B ridge count (P<0.01), ATD angle (P<0.02), pattern intensity index (P<0.05).Positive Family History is associated significantly with all the variables. Conclusion: To encapsulate six or more whorls are associated with high frequency with positive family history, Mean finger ridge count, and pattern intensity index is related in high frequency with menstrual age and ATD angle is linked in high frequency with nulliparity when compared with other reproductive factors.

Sensory nerve conduction velocity changes in low level laser therapy irradiated diabetic neuropathy induced wistar rats

Prathap Suganthirababu; Lavanya Prathap; Kumaresan A; Vignesh Srinivasan; Jagatheesan Alagesan; Praveenkumar Kandakurti

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 659-673

Background: Management of Diabetic neuropathy with physiotherapy is very limited and extensive research has to be done to address this problem conservatively in a physiotherapy perspective. The aim of the study is to analyze the effect of various dosage of low level laser irradiation on sensory nerve conduction velocity (SNCV) of experimentally induced diabetic neuropathy in wistar rats. Materials and Methods: We performed a randomized controlled trial using simple random sampling method in a CPCSEA Approved, Biomedical Research Unit & Laboratory Animal Centre, Chennai, India. The study carried out in two phases, in the phase I the selected experimental rats are treated with single dose on Alloxon 150mg/kg body weight after 12 hours of fasting. In the Phase II the samples with confirmed neuropathic status were divided into seven groups (six rats in each group) and irradiated with low level laser therapy with various dosages Results: The SNCV result analysis within the groups showed that laser dosage of 3,4j/cm2 are having more sensory regenerative effect as compared with 5-8j/cm2 dose and control group also did not show significant effect. The findings of the present study suggests nerve regeneration through nerve conduction velocity reports. Conclusion: It is evident from the results that an increase in nerve conduction velocity with selective dosages of laser proves that laser has neuroregenerative effects and by analyzing the results it can be concluded that low level laser of 3&4j/cm2 is found to be effective in regeneration of SNCV of experimentally induced diabetic neuropathy as compared with control group and with the dosage of higher energy with 5-8j/cm2.

Quantitative Evaluation of Normal Sucking range among Term Neonates. A prospective observational study.

Ramya Chandran; Jagatheesan Alagesan; Vanitha Jayaraj; Aravind Ganesh; Divyalaxmi P

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 227-234

Background: In normal term neonate rate of suck and swallow, and quantity of milk intake per suck will be increased gradually. Harmonized and safe way of oral feeding is depending on the maturity of nervous system, oral cavity and gastrointestinal tract. First indicator of neurological problem is feeding difficulty in infant period. Though several researches evaluated the patterns of suckling among preterm and term newborns, only a few studies have been conducted on the quantitative evaluation of sucking in term babies. Henceforth, the present study aimed to quantitatively evaluate the normal sucking range among term neonateduring breastfeeding.

EFFECTS OF DANCE-BASED MOVEMENT THERAPY ON BALANCE AND PREVENTING FALL IN CEREBELLAR ATAXIA: A CASE STUDY

Thanthoni S; Kumaresan A; Jagatheesan Alagesan; Aravind Ganesh; Rajkumar Krishnan Vasanthi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 402-409

Background: Individuals with cerebellar ataxia in its later stages frequently have major balance and immobility issues. There are currently no effective rehabilitation programmes for people with cerebellar ataxia that can assist them improve their motor impairment.
Objective of the study:

To determine the efficacy of dance-based movement therapy on balance in subjects with cerebellar ataxia, as well as to determine the effects of dance-based movement therapy on preventing falls in cerebellar ataxia subjects.
To determine the effects of dance-based movement therapy on balance in subjects with cerebellar ataxia, as well as to determine the effects of dance-based movement therapy on preventing falls in cerebellar ataxia subjects.