Online ISSN: 2515-8260

Author : AEJAZ AHMED, HAQUE MUDABBIRUL , SHIRSAT MRUNAL KRISHNARAO, KAYANDE NANDU,


PHYTOCHEMICALS INVESTIGATION OF ANTIOXIDANT, ANTICANCER ACTIVITY OF DRY FRUIT EXTRACT OF FICUS CARICA LINN IN EXPERIMENTAL ANIMALS

HAQUE MUDABBIRUL , SHIRSAT MRUNAL KRISHNARAO, KAYANDE NANDU, AEJAZ AHMED

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1420-1429

The antioxidant and anticancer activity dry fruit extract of ficus carica linn investigated against free radical scavenging activity (RSA) [reactions with 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and anticancer activity against Dalton’s ascitic lymphoma cell line and assessment of the influence of extracts on the enzyme xanthine oxidase (XO), and Fe3+ reducing ability. Antitumor activity was studied on swiss albino mice at various dose such as 250, 500, and 1000 mg/kg, body weight. The experimental parameter used were tumor volume, tumor cell count, viable tumor cell count, mean survival time and increase in life span to assess antitumor activity. The extract was administered orally for 14 consecutive days to tumor bearing group of animals. It increases the life span of DAL treated mice and restores the hematological parameters as compared with the DAL bearing mice in dose dependent manner. The study revealed that the extract of ficus carica (EFC) showed significant antitumor activity in tested animal models.