European Journal of Molecular & Clinical Medicine

Paracetamol have been extensively used in both the human and veterinary clinics due to its
antipyretic and analgesic properties.It is considered as a well-tolerated drug in patients
suffering from aspirin intolerance, ulcers, or difficulty in blood clotting. It is very important to
monitor the doses of paracetamol in the patient’s body under examination since the overdose
results in accumulation of toxic metabolites which may cause severe adverse effects. Due to a
wide use of paracetamol and the adverse effects of its over dose, it is alwaysbeing an
interesting issue to develop suitable techniques for its quantitative as well as qualitative
analysis. The development of simple, convenient, highly sensitive, versatile, fast and economic
techniques is very necessary to control the over uses of this drug causing many side effects.
Various techniques used for the determination and detection of paracetamol have been
reviewed in this paper predominantly focusing on electro-analytical methods.

Due to the increased resistance rate of Escherichia coli and Pseudomonas aeruginosa among
gram-negative bacteria, the risk factors of drug-resistant negative bacilli in patients should be
evaluated in the development of initial anti-infective treatment regimen in clinical practice. In
this study, multidrug-resistant bacteria accounted from the strains obtained by wound
cultures, which may be related to the patients with serious illness admitted to our hospital as a
tertiary care hospital and the more complex history of antibacterial drug use. This study puts
in a sincere effort to find the risk of diabetic foot ulcer with multidrug-resistant organism
infection.

Primum non nocere is a principle proclaimed by Hippocrates and remains relevant throughout the history of medicine. Unfortunately, pharmacotherapy does not always correspond to it. Although modern oral antibacterial drugs generally have a favorable safety profile, there are still many side effects. Antibacterial, like all medicines, have side effects, some of the side effects can be serious and some are dire. The use of antibacterial drugs in all areas of medicine, often unreasonable indications for their use, free access for the potential consumer - all this leads to irrational use of drugs, starting from an early age. More than 50% of diseases are infectious in nature. Infectious drugs account for 20% of all drugs currently used in medicine. The misuse of antibiotics is fraught with the development of antimicrobial resistance in the pathogen.

Nanotechnology has laid the foundation to nanomedicine production and still appears the cornerstone for ongoing global medical studies, since at nanometric scale the physical properties of materials vary, resulting in innovative magnetic, biochemical, visual and electrical characteristics. In addition to the huge amount of funds and capital, the emergence of new medicinal products against the changed pathological condition of our bodies is also challenging in view of maximum rate of failure. The modifications with in structures of products in nano particle form, altered the way of diagnosis and treatment of destructive human diseases by using medicines capable in effective management by modifying the step of discharge, delivery and disposal in the body. Smart nanoparticles are such one of the most demanding nano systems for drug delivery to targeted genes that can overcome the problems during treatment itself. Present review paper discussed the types and uses of various types of response-based smart nanoparticles to drug delivery practices.

The infection or contagoiuosness of a novel coronavirus found in China (2019-nCoV) is rapidly spreading and increasing worldwide. Due to the lack of effective treatment options for 2019-nCoV, various strategies are being tested all over the world. In this study, we are presented a medicinal impoertances of Hydroxy Chloroquine in the treatment of 2019-nCoV as it is having pretty much similarities with malaria in terms of primary symptoms. However not only Hydroxy Chloroquine can cure the disease, there is a need of proper vaccine for this particular virus to get control in its spread along with multi drug therapy. The present article is collectively presented a report on recent advancements in the medication application of Hydroxychloroquine

Background:
The compliance with standards in health services is non-negotiable as it is fundamental in improving KSA current poor health outcomes, restoring patient and staff confidence in the public healthcare system, achieving widespread sustainable development and providing basic quality healthcare in KSA. Despite the growing interest in understanding the a etiology of chronic diseases, limited studies exist on medication noncompliance, especially, among perturbing and rural dwellers in KSA. Barriers to medication adherence in patients can have significant differences that made researchers confute to conclude that medication adherence is required to be more explored, and then, beneficial interventions develop to decrease these barriers. Some of the main barriers to patient compliance with pharmacological therapy The barriers to medication adherence included four concepts, namely, lifestyle challenges, patient incompatibility, forgetting of medicine use, and no expert advice. These concepts are always present in the disease process and reduce the patients' efforts to achieve normal living and adhere to the medication. Medication non-adherence when patients don’t take their medications as prescribed is unfortunately fairly common, especially among patients with chronic disease.Most non-adherence is intentional patients make a rational decision not to take their medicine based on their knowledge, experience and beliefs There are many reasons for non-compliance with in patients for medication.
Aim of the study: To assessment of drug noncompliance among patients who are attending out patient's clinics in Primary Health Care Centers, Makkah, 2019 at Makkah Al-Mokarramah.
 Method:Across sectional descriptive study conducted among including Sample population consists of Saudi out patients aged 20-60 years attending to outpatient in selected primary health–care centers in Makkah Al-Mokarramah city, during the October to December, 2019, the Sample size of medical practitioners. Our total participants were (234).
Results:shows a statistically significant association socio-demographic (age, education, occupation, income) and Regular taking medication with (P-value <0.001) , respectively Chi-square (34.607, 72.638, 9.144, 32.151) Regarding gender shows no statistically significant association between gender and Regular taking medication with (P-value 0.364) , Chi-square (0.826).
 Conclusion: Recommendations to facilitate compliance with were described, which included implementation of effective management practices and allocation of adequate healthcare resources required to facilitate such compliance. ​The factors related to compliance may be better categorized as factors as the approach in countering their effects may differ. The study also highlights that the interaction of the various factors has not been studied systematically. Future studies need to address this interaction issue, as this may be crucial to reducing the level of non-compliance in general, and to enhancing the possibility of achieving the desired healthcare outcomes. Drug noncompliance not only includes patient compliance with medication but a lot of factors For example also with diet, exercise, or life style changes