Online ISSN: 2515-8260

Keywords : autoantibodies to neurospecific proteins and neurotransmitters

Pathogenetic Features Of Immuno-Biochemical Shifts In Children With Idiopathic Epilepsy

Madjidova Ekutkhon Nabievna; Abdullaeva MuazzamkhonIlkhomidinovna; Madjidova Nailya

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 4323-4330

The data obtained as a result of the studies carried out indicate the heterogeneity of patients with epilepsy from the point of view of molecular mechanisms, the development of the causes of epileptic seizures. One of the leading mechanisms of the pathogenesis of idiopathic epilepsy is a complex restructuring of neuroimmune relationships, manifested by a unidirectional increase in the level of autoantibodies to neurospecific proteins S100, GFAP, NF-200, MBP and the neurotransmitters glutamate, GABA, dopamine, serotonin and serotonine-channel. At the same time, the key link in the pathogenesis of idiopathic epilepsy is neurotransmitter imbalance. Circulating AATs to neurotropic proteins and neurotransmitter receptors in the blood serum of patients with epilepsy can be used as additional prognostic “immuno-biochemical” criteria for the course of the disease and the effectiveness of antiepileptic treatment.