Online ISSN: 2515-8260

Keywords : Proteomics


Significance of Complement factor and Immunoglobulin in Helicobacter pylori induced Gastric Cancer

PushpalakshmiGangadharan .; AnanthiSivagnanam .; SubekshaGovindaRajan Ravi; Chaitanya Vattem; Premkumar Karunakaran; Raja JeyaSekar R; Megala Jayaraman; Pushparaj Arunachalam

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 128-142

Background: Gastric cancer (GC) still found to be the predominant cancer in Asia.There were very few reports which were focused on population specific biomarker studies with respect to Helicobacter pylori (H. pylori) induced gastric cancer in India. Hence, we aimed to perform this biomarker study involving H. pylori positive and negative healthy serum samples in comparison with H. pylori positive gastric cancer samples.
Methods: We have adapted Proteome based approaches to identify serum biomarkers in our Indian population samples. For proteins separation and identification, 2D gel electrophoresis with tandem mass spectrometry approach was performed and thirty differentially regulated protein spots were analyzed.

CHANGING SCENARIO IN ORAL PATHOLOGY

Dr.Priyanka Singh; Dr. Manpreet Arora; Dr. Aparna Dave; Dr. Pulin Saluja; Dr.Radhika Rai

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 2016-2024

This review article covers the current research areas in oral pathology and reflects the broad range that encompasses the development and application of software in digital histopathology, implementation of biomarkers in pathology, genetics and epigenetics. Molecular pathology, regenerative medicine and immuno therapy, holds the promising and optimistic future of pathology. Oral and maxillofacial pathology is standing at the forefront of the revolution and new diagnostic tools and knowledge are taking pathologists into broader roles of research and correlating diagnoses for clinicians. While we are still using the same method and material that has been using for the past 100years, it’s time to change. Digital technologies could push the field into becoming more efficient and more scalable. Utilizing  high-throughput, automated digital pathology scanners, it is possible to capture an entire glass slide, under bright field or fluorescent conditions, at a magnification comparable to a microscope. Digital slides can be shared over networks using specialized digital pathology software applications. The future of digital pathology could eventually encompass enhancedtranslational research, computer aided diagnosis (CAD) and personalized medicine.

Omics Technology for Abiotic Stress Response in plants

Siya Sharma; Neelam P Negi

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4543-4561

Abiotic stress is one of the major factors which affect the growth and yield of
crops. This is due to several imbalances which occur at the plants molecular, cellular and
developmental levels during stress conditions. Due to these disturbances in plants, the
defence mechanism gets activated in response of stress and the detection of these changes
is possible because of computational biology that facilitate the multi-target approach.
However, with the advancement of omics technology plants are seen to acclimatize
themselves by modulating at the genomics, transcriptomics, proteomics. In this review, all
the molecular changes of plants under stress is discussed and the new insights which are
obtained from the integration of omics are highlighted.

Proteomics and Oral Cancer: The Road Less Travelled

Dr. Kumar Gaurav Chhabra; Nandini Hake; Sayali Limsay; Radhika Kulkarni; Dr. Gargi Nimbulkar; Dr. Amit Reche

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 1816-1825

The oral squamous cell carcinoma (OSCC) is evaluated as the eighth driving reason for malignant growth all inclusive. OSCC shows high predominance and grimness, with the death pace of 145,000 passing for every year universally. The result of the treatment and anticipation of oral cancerous growth relies for the most part upon early finding. For the high morbidity of the oral cancer, deferred identification is probably going to be an essential explanation and this backing the basic requirement for sensitive biomarkers to improve early recognition of oral malignant growths. Along these lines, early location and counteraction of oral cancerous growth is one of the destinations set by World Health Organization (WHO). Abnormal cellular products from malignant cells can be recognized and estimated in different body fluids, for example, blood, urine and saliva. Saliva can be utilized to identify biomarkers explicit for oral cancer as it is anything but difficult to acquire and non-intrusive, additionally due to its immediate contact with oral cancer, salivary assessment for discovery of oral cancer can show the best benefit. Biomarkers are utilized for patient assessment in various clinical settings. They are likewise utilized for assessing disease risk, screening for mysterious primary cancers, differentiating benign from malignant findings/one sort of malignancy from another, determining prognosis, acting as indicators/screening, and observing disease status. Salivary biomarkers can possibly recognize normal biological, pathological as well as pharmacological response to treatment. Huge endeavours from scientists and clinicians are significant so as to transform salivary diagnostics into clinical and commercial reality and in this way helping in battling oral disease. This article gives survey of salivary proteomic biomarkers, strategies for examination of salivary proteomic biomarkers and their clinical significance in early discovery of oral cancers.