Online ISSN: 2515-8260

Keywords : Oligohydramnios


Comparison Of Doppler And Non-Stress Test In Oligohydramnios For Assessment Of Perinatal Outcome Beyond 34 Weeks

Dr. Puja Singh, Dr. Ratna Tejaswi Papola, Dr. Maryada Jain, Dr. Shubhra Agarwal, Dr. Rehana Najam

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 9783-9789

Background: Oligohydramnios has been associated with a higher risk of labor induction
and cesarean birth, as well as a higher risk of maternal morbidity. This study was done
to compare between Non-Stress Test and Doppler Velocimetry in oligohydramnios for
maternal & fetal outcome beyond 34 weeks of pregnancy.
Methods: Patients with oligohydramnios <5cm with more than 34 week of gestation and
having normal NST and Normal color doppler were managed conservatively and
followed up to term.After collection of all data in Microsoft Excel and statistical analysis
was done by using SPSS version 22 with significant value (P value < 0.05).
Results: The majority (54.7%) of patient with oligohydramnios were in the age group
between 26-35 years. APGAR less than 7 was significantly more among groups C
(Doppler Normal/NST Abnormal) and D (Doppler Abnormal/NST Abnormal). NICU
admission was significantly more among group D. The mean NICU stay was
significantly more among groups B (Doppler Abnormal/NST Normal) and D. The mean
weight at birth was significantly more among groups A (Doppler Normal/NST Normal)
and C. The sensitivity and specificity of Doppler (78.60, 82.50) was more as compared to
NST (62.5, 61) in prediction of perinatal outcome.
Conclusion: This study concluded that Doppler is a stronger indication of early Fetal
impairment than NST because NST detects acute events in the presence or absence of
chronic hypoxia, but Doppler detects chronic alterations.

Association between second trimester maternal serum alphafetoprotein in 14-22 weeks and adverse pregnancy outcome

Heena Mir, Saima Sadiq,Sabha Malik

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 225-230

Background:Many screening tests are available for predicting adverse pregnancy outcome
and these range from non- invasive to invasive and serum alpha-fetoprotein level
estimation is one of them. The present study was conducted to assess association between
second trimester maternal serum alpha-fetoprotein in 14-22 weeks and adverse pregnancy
outcome.
Materials & Methods: 250 patients of gestational age between 14-22 weeks were included.
Maternal serum alpha-fetoprotein was measured in human serum by microplateimmunoenzymometric
assay by EIA-AFP kit. Maternal serum alpha-feto protein level was
expressed in IU/ml.
Results: 23 (9.2%) participants out of 250 developed preterm labor. 21 out of 23 had raised
value of maternal serum alpha-fetoprotein. 20 (8%) patients out of 250 patients developed
oligohydramnios. 13 out of 20 had raised value of maternal serum alpha-fetoprotein. 14
(5.6%) patients out of 250 developed pre-eclampsia, 11 out of 14 had raised values of
maternal serum alpha-fetoprotein. 7 (2.8%) patients out of 250 developed premature
rupture of membrane (PROM). 4 out of 7 had raised values of maternal serum alphafetoprotein.
Conclusion: There is an increased risk of pre-eclampsia, preterm delivery,
oligohydramnios and premature rupture of membrane with elevated maternal serum
alpha-fetoprotein levels

STUDY OF PERINATAL OUTCOME IN OLIGOHYDRAMNIOS IN PREGNANCY

Akshara alex, Dharmavijaya

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 1530-1538

Introduction - Oligohydramnios or a reduced volume of amniotic fluid poses a challenge in
 obstetric management, particularly when it is diagnosed before term. It is one of the major
 causes for antenatal fetal surveillance and induction of labor. The incidence of
 oligohydramnios in the literature varies from less than 0.5%1 to above 5%, depending on the
study population and definition of oligohydramnios. Oligohydramnios, often due to impaired
 placental function, has been associated with an increased risk of caesarean delivery for fetal
 distress, as well as low Apgar score, postmaturity, meconium aspiration syndrome and
 perinatal mortality and morbidity.

A COMPARATIVE STUDY OF THE EFFECT OF ORAL AMINO ACID SUPPLEMENTATION VS INTRAVENOUS AMINO ACID INFUSION ON AMNIOTIC FLUID INDEX AND PERINATAL OUTCOME IN PREGNANCIES COMPLICATED BY OLIGOHYDRAMNIOS AND FOETAL GROWTH RESTRICTION

Dr. AKRUTI SHINDE; Dr. MEHUL SALVE

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2018-2026

BACKGROUND: The primary function of amniotic fluid is protection of the growing foetus while providing nutrition. A considerable amount of research has been conducted to evaluate interventions to improve amniotic fluid index and the subsequent impact on foetal growth restriction and oligohydramnios. However, there isn't any conclusive evidence hence this study aims to compare the effect of oral amino acid supplements and intravenous infusions in pregnancies with oligohydramnios and foetal growth restriction. 
AIM: To compare the effect of oral amino acid supplementation vs intravenous amino acid infusion on amniotic fluid index and perinatal outcome in pregnancy complicated by oligohydramnios and foetal growth restriction
OBJECTIVES: To compare the effectiveness of oral amino acid supplementation vs intravenous amino acid infusion in pregnancy having oligohydramnios and foetal growth restriction. To study the increase in amniotic fluid index in pregnancy with foetal weight gain. To study the interval growth rate of baby after two weeks and four weeks of therapy.
MATERIAL AND METHOD: This Semi experimental study will be conducted in Department of Obstetrics and Gynaecology, AVBRH, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha. A total of 104 clinically and sonographically proven cases of foetal growth restriction & Oligohydramnios in third trimester attending antenatal clinic or admitted in wards, fulfilling the exclusion and inclusion criteria will be comprise the study groups. After providing oral supplements or intravenous infusions arbitrarily, repeat ultrasonography will be done after two weeks and four weeks of therapy.
EXPECTED RESULTS: We compare from our results the effect of oral amino acid supplementation vs intravenous amino acid infusion on amniotic fluid index and perinatal outcome in pregnancies complicated by oligohydramnios and foetal growth restriction.