Online ISSN: 2515-8260

Keywords : leptin



European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2040-2048

BACKGROUND – Insulin resistance and profound changes in body weight are common features of pregnancy. Obesity in pregnant women and glucose intolerance due to insulin resistance, ultimately leading to Gestational Diabetes Mellitus (GDM), both can add to poor maternofetal outcome such as, macrosomia, prematurity, shoulder dystocia, preeclampsia, and even increased chances of fetal demise. Leptin is a novel potential regulator of insulin resistance. Measuring serum leptin levels in pregnant women with different BMI categories may potentially help in early detection of GDM, and predicting poor maternofetal outcome at early stages of pregnancy.
1. To study serum leptin levels in women with GDM
2. To study the body mass index in women with GDM and classify study subjects according to BMI
3. To study the serum leptin levels in women with GDM belonging to various BMI categories and evaluate its association.
4. To correlate serum leptin and BMI with materno-fetal outcome in women with GDM
METHODOLOGY – This prospective hospital based study will be conducted in department of obstetrics and gynecology, at Acharya Vinoba Bhave Rural Hospital (AVBRH). 96 pregnant women seeking care at outpatient unit and/or in patient unit of Obstetrics & Gynaecology, in the AVBRH hospital, Sawangi, Meghe, in first trimester, will be included in the study. Screening for GDM in twice, first as soon as possible after diagnosis of pregnancy (first trimester) and second between 24-28 weeks, fasting Serum Leptin will be measured at 28 -32 weeks of gestation.
EXPECTED RESULT - It is expected that levels of Sr. Leptin will be higher in the women with GDM and will be abnormal in various BMI categories with a proportionate rise with increasing BMI.


Karan Vannia; Mohammad Murtaza Mehdi

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 3024-3032

Eating disorders – anorexia nervosa and bulimia nervosa are one of the multi factorial disorders which are affected by genetic, neural, social and psychological factors. These factors themselves don’t have independent existence and found to interfere with each other in order for the development of disorder. In this review, causes of eating disorders is been mentioned. Both of the major disorders also don’t have independent nature and are connected to each other. It acts like a cycle of symptoms where one symptom brings to the other kind of disorder. These disorders are not something new and dates long back to history. Importantly, recent times have created a keen interest among biologists and scientist to know genetic basis of these disorders where the information enrichment is also going on by hormonal and neural changes which are slowly and slowly accessed. Certain hormones such as leptin, adiponectin found to be affected in the case of disorder. Societal and familial aspects are also reviewed which is of obvious importance. This review is important for Biology, Psychology and Sociology point of view.