Online ISSN: 2515-8260

Keywords : serum uric acid


A study on association of serum uric acid and blood pressure in hypertensive patients at a tertiary hospital

Premaraja R, Bethiun S

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2013-2019

Background: Hypertension is an increasing important medical and public health issue. Uric acid exerts a pro-inflammatory effect on endothelial cells which may be associated with MetS risk factors such as elevated triglyceride (TG) levels, hypertension and insulin resistance.5 Present study was aimed to study of association of serum uric acid and blood pressure in hypertensive patients at a tertiary hospital.
Material and Methods: Present study was prospective, comparative, observational study, conducted among cases (Subjects of either gender, age >18 years, diagnosed as hypertensive (first time) were enrolled in this study during a regular routine health check-up at general medicine OPDs) & controls (Age & gender matched normotensives subjects at general medicine OPDs).
Results: In present study, 100 subjects each were studied in hypertensive as well as normotensive group. Mean levels of age, gender, BMI & co-morbidities among both groups were comparable & difference was not significant statistically. Mean pulse rate & respiratory rate were comparable among both groups & difference was not significant statistically. The mean levels of SBP and DBP were significantly more in the hypertensive subjects as compared to normotensive subjects (p < 0.001). In present study, prevalence of hyperuricemia was 9% (1% in normotensive and 8% in hypertensive subjects). Hypertensive subjects had increased mean levels of SUA than in the normotensive subjects (p < 0.001). In Pearson’s correlation coefficient test, SUA levels were significantly related with SBP and DBP (p < 0.001). The average level of TG and HDL were also significantly different between the groups (p < 0.05).
Conclusion: A stronger co-relationship for higher levels of SUA concentration was noted with blood pressure hypertension and prehypertension in the participants.

A study on association of serum uric acid and blood pressure in hypertensive patients at a tertiary hospital

Premaraja R, Bethiun S

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1244-1249

Background: Hypertension is an increasing important medical and public health issue. Uric acid exerts a pro-inflammatory effect on endothelial cells which may be associated with MetS risk factors such as elevated triglyceride (TG) levels, hypertension and insulin resistance.5 Present study was aimed to study of association of serum uric acid and blood pressure in hypertensive patients at a tertiary hospital.
Material and Methods: Present study was prospective, comparative, observational study, conducted among cases (Subjects of either gender, age >18 years, diagnosed as hypertensive (first time) were enrolled in this study during a regular routine health check-up at general medicine OPDs) & controls (Age & gender matched normotensives subjects at general medicine OPDs).
Results: In present study, 100 subjects each were studied in hypertensive as well as normotensive group. Mean levels of age, gender, BMI & co-morbidities among both groups were comparable & difference was not significant statistically. Mean pulse rate & respiratory rate were comparable among both groups & difference was not significant statistically. The mean levels of SBP and DBP were significantly more in the hypertensive subjects as compared to normotensive subjects (p<0.001). In present study, prevalence of hyperuricemia was 9% (1% in normotensive and 8% in hypertensive subjects). Hypertensive subjects had increased mean levels of SUA than in the normotensive subjects (p<0.001). In Pearson’s correlation coefficient test, SUA levels were significantly related with SBP and DBP (p<0.001). The average level of TG and HDL were also significantly different between the groups (p<0.05).
Conclusion: A stronger co-relationship for higher levels of SUA concentration was noted with blood pressure hypertension and prehypertension in the participants.

A PROSPECTIVE STUDY OF SERM CALCIUM, MAGNESIUM, URIC ACID AND LIVER ENZYMES IN PREGNANCY INDUCED HYPERTENSION

Dr.Borra Dharmendhar, Dr.Laxmi Chapidi, Dr.Ketham Veera Sudhakar, Dr.Kankata Jhansi Rani

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1328-1333

Introduction: Hypertensive disorders in pregnancy (HDP) are one of the deadly triads, along with hemorrhage and infection, and are responsible for 10.8% of maternal mortality in India. In preeclampsia and eclampsia, significant changes are seen in various biochemical parameters like uric acid and serum calcium. Hyperuricemia due to oxidative stress is associated with deleterious effects on endothelial dysfunction, oxidative metabolism, platelet adhesiveness, and aggregation. Hence, elevated serum uric acid is highly predictive of increased risk of adverse maternal
and fetal outcomes. Blood calcium has a relaxant effect on the blood vessels of pregnant women.
Materials and Methods: A prospective study was conducted at the department of Obstetrics and Gynecology, Kakatiya Medical College and MGM hospital, Warangal from1st October 2021 to 30th September 2022 (1 year).We have selected 100 cases and 100 controls. The control group was women who fulfill the same previously mentioned criteria, but who did not develop hypertension during the 3rd trimester. They were all normotensive with a systolic blood pressure of 130 mmHg or less and a diastolic blood pressure of 80 mm Hg or less.
Results: The present study includes 100 cases with pregnancy induced hypertension and 100 controls with normal healthy pregnancy. Age Distribution in Study Population Mean ± SD of age showed no significant difference with Mean ± SD of cases at 22.62 ± 3.61 yrs. compared to that of controls at 23 ± 4.04 yrs. and a p-value of 0.62. Gestational Age in Study Population Mean gestational age showed high significance with Mean ± SD of cases at 36.38 ± 4.19 weeks compared to that of controls at 39.62 ± 1.16 weeks with a p value of < 0.001.
Conclusion: Possibly, serial measurements of the serum uric acid and liver enzymes from early pregnancy can bring forward a selected group of high risk women for treatment. Thus, it can be concluded that Calcium and Magnesium can be evaluated at an early date so that such mineral deficiencies can be treated by appropriate Calcium and Magnesium supplements. Uric acid and Liver enzymes can possibly be used as biomarkers for identifying and avoiding adverse pregnancy outcomes by prompt intervention

“TO STUDY SERUM LDH AND SERUM URIC ACID LEVELS IN NORMOTENSIVE AND PREECLAMPTIC-ECLAMPTIC PREGNANT WOMEN AND ITS CORRELATION WITH FETO-MATERNAL OUTCOME.”

ELETI MANILA REDDY; MANJUSHA AGRAWAL

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2075-2082

BACKGROUND: A major health problem is hypertension during pregnancy. This complicates In India, around 5 to 10 percent of pregnancies occur. Preeclampsia is a disorder whose pathogenesis is still not clearly understood. One theory suggested that the cause of PE is, endothelial dysfunction is brought about by certain factors released from ischemic placenta leading to poor uterine and placental perfusion. Preliminary executive research suggests that serum LDH and uric acid are abnormal in women with preeclampsia-eclampsia and usual in women with normotension. AIM AND OBJECTIVES: We aim to study the correlation between serum lactate dehydrogenase levels and serum uric acid levels in in normotensive pregnant women and preeclamptic-eclamptic pregnant women together with their feto-maternal performance. The objectives of the study to compare and correlate serum lactate dehydrogenase and serum uric acid levels in normotensive and preeclamptic-eclamptic women with feto-maternal outcome. MATERIALS AND METHODS: This is a prospective observational study and will be conducted in the obstetrics and gynaecology department, AVBRH, DMIMS (Deemed to be University, Wardha), situated in the rural area of Wardha district in over 230 patients for period between 2020-23. This study will include antenatal patients of age 18 - 35yrs, gestation 28-40 weeks, normotensive and preeclampsia-eclampsia women and will exclude mothers with hypertension < 20 weeks of gestation (Chronic Hypertension), multiple pregnancy, pre-existing Diabetes Mellitus, liver disorder, renal disorder, epileptic disorder, thyroid disorder, Heart Disease, leukaemia, haemolysis and hepatitis. EXPECTED RESULTS: We expect that there will be significant difference in maternal and fetal outcome based on serum lactate dehydrogenase and serum uric acid concentration in normotensive and preeclamptic -eclamptic pregnant women.