Online ISSN: 2515-8260

Keywords : PCOS


A STUDY ON GYNAECOLOGICAL PROBLEMS IN ADOLESCENT GIRLS AND ETIOLOGICAL FACTORS IN GOVERNMENT MEDICAL COLLEGE, KADAPA

Kesavachandra Gunakala, P.M. Rekharao, T. Bhavya, Vennela Mude

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 2360-2375

Background: Low socio economic group hailing from rural population was the maximum group of girls studied. To study various gynaecologicalproblems and etiological factors encountered in adolescent girls who attended the gynaecological OPD, at GMC, Kadapa.
Materials and Methods: A total of 200 cases of adolescent girls aged 10 -19 years who attended gynaecological OPD and emergency department. Detailed history with regard to gynaecological problems was taken from the patient and girl‟s mother was also interviewed to get accurate details about any previous medical problems if present.
Results: Maximum incidence of gynaecological problems was seen in age group of 17years. Among the various presenting complaints in studied adolescent girls, menstrual irregularities were the most common. Oligomenorrhoea was the most common menstrual problem in this study. Anovulation is the most common cause of menorrhagia in adolescents. Majority of adolescent girls suffered from anemia ranging from mild to severe types of anemia. 5.56% patients with puberty menorrhagia received blood transfusion. The most common cause of oligomenorrhoea was the hypothalamic pitutary gonadal dysfunction. Counselling and reassurance was an integral part of treatment strategies. PCOS and hypothyroidisms were the other endocrinological abnormalities common among the adolescent girls. Leucorrhoea in adolescent girls in my study were most commonly. physiological, counselled and explained to maintain proper hygiene.
Conclusion: A combined effort of team comprising gynaecologist, endocrinologist is required in arriving final diagnosis in case of primary amenorrhoea.

Risk Factors For Polycystic Ovarian Syndrome Among Adolescent Girls In Urban Visakhapatnam

Dr. D. Errayya, Dr SunitaSreegiri, Dr.Ch Padmavathi,Dr. B Devi Madhavi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 28-35

Introduction:Polycystic ovary syndrome (PCOS) is the most common endocrine
abnormality affecting women of reproductive age, but this condition is still not
completely understood. As it is linked with many chronic conditions such as
cardiovascular and diabetes, there is need to identify the condition at the earliest.
Methods: A cross-sectional Community-based study was conducted in urban
Visakhapatnam in November 2020 among 132 adolescent girls aged between 15 to 19
years to study the prevalence of PCOS among adolescents to identify the risk factors for
polycystic ovarian syndrome. Multistage sampling was used to select the study
participants from six urban zones, information collected using a PCOS validated
questionnaire modified to suit locally. Diagnosis of PCOS was based on
Rotterdam/ESHRE criteria examination for obesity, hirsutism, acne and acanthosis.
Results: Six percentof the study subjects were found to have possible diagnosis of
PCOS. Family history of risk factors for PCOS such as maternal menstrual
irregularities, diabetes and obesity was found in 12.1% of study subjects.Increased BMI
was seen in 6.8% girls and 24 .1% had abnormal menstruation.
Conclusion:Family history, increased BMIand presence of clinical findings as abnormal
growth of hair and acne are found to be significantly associated.

A prospective assessment of the suitability of Letrozole as ovulating induction agent in patients with PCOS induced infertility

Dr. R Swapna, Dr. Akila Sree Gowri

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1404-1409

Aim: to evaluate Letrozole as suitable ovulating induction agent in patients with PCOS induced infertility. Material & Method: The main source of data for this study are the women with primary and secondary infertility with anovulation attending the Department of Obstetrics & Gynecology, RVM Institute of Medical Sciences and Research Centre, Siddipet, Telangana, India. This is a prospective study with a total of 200 women satisfied the inclusion and exclusion criteria of the study. The present study consists of cases of infertility due to anovulation which were thoroughly evaluated before the diagnosis of anovulation was confirmed. Results: In this study mean age of the patients were 28.0 years and mean age of husbands were 32.4 year. 105 patients underwent diagnostic hysterolaparoscopy with chromopertubation + ovarian drilling. Conclusion: Letrozole can be considered as suitable ovulating induction agent in patients with PCOS induced infertility. It is a better drug in terms of mono follicular ovulation and better endometrial thickness than other ovulation induction agents. It has high ovulation rate with significant conception rate, with only drawbacks being miscarriages.

A STUDY ON ROLE OF DIAGNOSTIC HYSTERO- LAPAROSCOPYIN EVALUATION OF FEMALE INFERTILITY AT TERTIARY CARE CENTRE

Vege Vishnu Santhi, Sajana Gogineni, K.B. Gayathri

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 11771-11779

Background:Living as an involuntarily childless woman is challenging for feminity and female roles in society. Infertility affects about 10-15% of reproductive age couples. WHO estimates that 60-80 million couples worldwide currently suffer from infertility. The causes of female infertility are multifactorial and necessitate comprehensive evaluation. Laparoscopy with chromopertubation is viewed as the “gold standard” test for tubal assessment. Adding Hysteroscopy to the procedure allows for concomitant evaluation of intrauterine cavity. With this preview, my study aims at evaluating the role of diagnostic hystero-laparoscopy as a safe & cost- effective tool for assessment of unexplained female infertility.
Materials and Methods: An observational hospital based study on 260 patients was carried out in a tertiary care centerDr. PSIMS &RF, Vijayawada, Andhra Pradesh, India -over a period of 2.5 years from October 2019 to April 2022. Women aged 18-40yr with normal hormone profile without male factor infertility were included.
Results: Out of 260 cases, 60.93% patients had primary infertility. PCOS was found to be the most commonly associated with primary infertility. Whereas the most common causes of secondary infertility were found to be PID, endometriosis and endometrial polyps each respectively. Hysterolaparoscopy revealed intrauterine lesions and therapeutic measures like ovarian drilling, lysis of intrauterineadhesions, cystectomy, polypectomy and septal resection were carried out.
Conclusion: Hysterolaparoscopy is an effective diagnostic tool for evaluation of correctable tuboperitoneal pathologies like endometriosis, polycystic ovaries, adnexal pathologies and subseptate uterus which are usually missed by other imaging modalities. When done by a trained and experienced investigator and with proper selection of patients, hysterolaparoscopy proves to be a definitive investigative procedure for evaluation of female infertility. It also helps in formulation of a treatment modality.

Correlation of vitamin D and Parathyroid hormone with insulin resistance in PCOS women

Govind Kahar, Akanksha Shrivastava,Rupali Sharma, Sonal Prasad

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 422-427

Aim: To investigate the relation of vitamin D concentration and parathyroid hormone with
insulin resistance in PCOS women.
Methods: In the department of Obstetrics and Gynecology at Dr. Baba Saheb Ambedkar
Medical College & Hospital, Rohini, Delhi, a one-year observational study was conducted.
The levels of 25, hydroxyvitamin D and PTH, as well as the levels of fasting sugar and
insulin in the blood, were tested.
Results: There was a 91.0 percent prevalence of vitamin D insufficiency (<20 ng/ml) in the
study, whereas 67.9 percent of participants had an elevated parathyroid hormone level.
According to the study, vitamin D insufficiency (r=-0.64, p=0.01) had a significant negative
connection with the HOMA-IR. Increased PTH levels were shown to have a positive
correlation with HOMA-IR.
Conclusion: Women with PCOS who have high parathyroid hormone levels or vitamin D
insufficiency have a higher incidence of glucose intolerance.
If vitamin D insufficiency and insulin resistance are strongly linked, it may be possible to
treat insulin resistance by raising vitamin D levels.

Correlation of vitamin D and parathyroid hormone with insulin resistance in PCOS women.

Dr. Govind Kahar, Dr. Akanksha Srivastava,Dr. Rupali Sharma, Sonal Prasad

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 731-735

Aim: To investigate the relation of vitamin D concentration and parathyroid hormone with
insulin resistance in PCOS women.
Methods: In the department of Obstetrics and Gynecology at Dr. Baba Saheb Ambedkar
medical college & hospital Rohini Delhi, a one-year observational study was conducted. The
levels of 25, hydroxyvitamin D and PTH, as well as the levels of fasting sugar and insulin in
the blood, were tested.
Results: There was a 91.0 percent prevalence of vitamin D insufficiency (

“EVALUATION OF HOMOCYSTEINE LEVELS AND ITS CORRELATION WITH CLINICAL, METABOLIC AND HORMONAL PROFILE OF WOMEN WITH PCOS”

PRIYANJALI SINHA; NEEMA ACHARYA; PRIYANKA SINGH

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2104-2112

Background: PCOS is the most common endocrinological disorder affecting 6 -14% amongst reproductive age group. The pathophysiology of PCOS is complex and it is still not well understood. Many markers have been studied to correlate between homocysteine level and other clinical, metabolic and hormonal profile. Preliminary investigations indicate that in women with PCOS, serum biomarkers of cardiovascular disorders such as homocysteine are abnormal. Furthermore the interactions between homocysteine and PCOS, biochemical features such as obesity, insulin resistance and higher levels of androgen, have been researched and the potential determinant of this finding is still being explored.
Aim and Objectives: We aim to determine association between hyperhomocysteinemia and PCOS. The objectives of this study is to evaluate and compare clinical, metabolic and 
hormonal profile in women of PCOS with normal homocysteine level with that of increased homocysteine level.
Materials and Methods: This is a prospective observational study which will be performed in the department of obstetrics and gynaecology, AVBRH, DMIMS (Deemed to be University, Wardha), a tertiary care teaching hospital situated in the rural area of Wardha district in over 140 patients for period between 2020-22. This study will include PCOS patients based on Rotterdam diagnostic criteria and will exclude patients with known metabolic, cardiovascular and endocrine disorders. Metabolic and hormonal profile will be evaluated with BMI, Lipid profile, Insulin resistance, serum levels of LH, FSH, DHEA and Testosterone in all patients. Serum homocysteine levels will be measured using ELISA.
Expected Results: We expect that there will be significant difference in clinical, metabolic and hormonal profile of PCOS women having hyperhomocysteinemia than women having normal homocysteine level.

Clomiphene Citrate and Anastrozole : Effects on Follicular Diameter and Endometrial Thickness in Polycystic Ovary Syndrome

Yashinta Sampeliling; Andi Mardiah Tahir; Eddy Hartono; Firdaus Kasim

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4962-4967

Objective: To compare the effects of clomiphene citrate and anastrozole on follicular diameter and endometrial thickness in women with polycystic ovary syndrome (PCOS).
Methods: This prospective study was conducted at the private-practice setting. The study group consisted of 14 patients who received clomiphene citrate 50 mg and 14 patients received anastrozole 1 mg on day 3 of menstruation for 5 days. Follicular diameter and endometrial thickness were measured with transvaginal ultrasound on day 12 of menstruation.
Results: The mean diameter of follicles in the clomiphene citrate group was not significantly differ compared with anastrozole group (13.35±4.72 mm vs 10.92±4.29 mm; p>.05, respectively). A similar effect also observed in endometrial thickness for both study groups (8.51±1.88 mm in anastrozole vs 7.49±2.09 mm in clomiphene citrate; p>.05).
Conclusion: Clomiphene citrate and anastrozole were not significantly improved follicular diameter dan endometrial thickness in polycystic ovary syndrome.