Online ISSN: 2515-8260

Keywords : fetomaternal outcomes

Study of Arterial Blood Gas, Acid Base Balance and its CorelationwithFetomaternal Outcome inPregnancy Induced Hypertention

Dr. Poorvi Gupta, Dr. Pooja Deodhar, Dr. Mohini Thakur

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 2962-2969

Background &Method: To evaluate the maternal outcomes through ABG index and its
influence on new-borns through Apgar scoring. Role of arterial blood gas values and their
implications to patient management.A total of 130 women with PIH syndrome were treated in
Department of Obstetrics and Gynaecology of IMCHRC, Indore, over a period of 12 months
Result:In this study, 66.10% PIH patients improved by conservative management, whereas
33.88% required ventilatory support of which 5.08% died on mechanical ventilation.
Amongst which maximum patients which succumbed showed decompensated metabolic
acidosis at 0 hr ABG.In this study, the mean pH value, PO2, HCO3 in severe PIH cases were
lower than the mild PIH cases, whereas the mean PCO2 and BE levels in severe PIH cases
were higher than the mild PIH cases. Therefore, with the exerbation of the disease,the
differences of indexes from normal values became larger.


Dr. Sharmeen I. Memon; Dr. Neema S. Acharya

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2140-2149

Background: One of the major causes of adverse Fetomaternal outcomes have been found to be the various Placenta mediated pregnancy Complications (PMCs). There are inconsistent studies that confirms or proves elevated Serum Homocysteine concentration to be one of the risk factors for Placenta Mediated Complications. Prospective and sufficiently powered studies that uses the pathophysiology of the disease as the basis of their study will help and encourage for a better management of women and fetuses at risk. Hence, this study focuses to determine whether elevated maternal plasma Homocysteine levels in early to mid-second trimester has any significant difference on the occurrence of Placenta-Mediated Complications (PMCs). Objectives: To study and compare the occurrence of Placenta mediated Complications and their Fetomaternal Outcome in women having normal and elevated Serum Homocysteine levels.
Methodology: Females in their early second trimester (Gestational age within 12 -20 weeks) with singleton pregnancy irrespective of taking or not taking periconceptional folic 
acid, presenting for prenatal care in the ANC clinic or planning to deliver at AVBRH Hospital will be selected. Fasting Blood samples will be taken in EDTA Vacutainer tubes and transported to the laboratory within 30min and then the maternal Serum Homocysteine levels will be estimated using the Enzyme-Linked Immunosorbent Assay. Women with raise Plasma Homocysteine Levels will be categorized into Group A and women with Normal Plasma Homocysteine Levels will be categorized into Group B. Pregnancy outcomes and complications will be extracted by studying the antenatal, perinatal, and postnatal medical records and comparison will be made between both the groups for the level of significance.
Results: The Expected Outcome of this study will be a significant difference in the occurrence of Placenta Mediated Complications and related Adverse Fetomaternal Outcomes in women having elevated and normal Serum Homocysteine Levels.
Conclusion: Our Study will prove the role of maternal homocysteine levels in occurrence of Placenta-mediated pregnancy Complications.