European Journal of Molecular & Clinical Medicine

Background : Osteoarthritis (OA) is the most common type of arthritis. OA is a chronic degenerative disorder of multifactorial etiology characterized by the loss of articular cartilage, hypertrophy of bone at the margins, subchondral sclerosis, and range of biochemical and morphological alterations of the synovial membrane and joint capsule. For finding the current burden of OA and its association with lifestyle related factors, it was essential to undertake such a study on the  Knee Osteoarthritis
Methods: This is an institution based cross sectional observational study carried out among patients with knee pain & disability attending Out Patient Department of Medical College Datia. The total sample size was 304 subjects. Tools consisted of a questionnaire and plain skiagrams for confirmation of OA. Diagnosis was done using Kellgren and Lawrence scale for osteoarthritis. Questionnaire was administered only to those who gave informed consent.
Results: Thestudy shows a 31.5 % cases found  in the overall  304 interviewed  Patients present with complain of knee pain. Female of the age group 46-60 are more prone to osteoarthritis comparative to other age group people. Highest %  in participants who have a sedentary lifestyle and Obese.
Conclusions: This study conclude the age group, gender, occupation, stages of severity of knee OA in Datia. Awareness program should be initiated at community level which is needed for the prevention of OA of knee at early age. We would like to suggest that a study can be planned which will prove the impact of physical activity, habits, and lifestyles.

Knee osteoarthritis is one of the most common joint disorders, and it causes severe pain and immobility. Total knee replacement (TKA) is very effectively relieves pain and improves knee function in patients with late-stage knee osteoarthritis. However, TKA is expensive and complex, and some patients need a second revision. The study included patients with medial compartment osteoarthritis, who were treated by proximal fibular osteotomy. The patients were diagnosed of knee osteoarthritis by American College of Rheumatology criteria and severity of disease was graded by Kellgren and Lawrence grading system. In our study, total number of patients was 27. Among them 3 were bilateral cases. Hence total number of knees was 30. Among 30 knees, 14 were right knees and 16 were left knees. The diagnosis of stage of osteoarthritis was done by using Kellgren and Lawrence classification system. Among 30 knees, 16 cases were in Stage 2, 13 cases were in Stage 3 and 1 case was in Stage 4

Knee osteoarthritis (OA) being the commonest joint disease has an incidence of 30% in population above 60 yrs. Proximal Fibular osteotomy (PFO) though in exploratory stage has aroused lot of interest in orthopedic surgeons as it seems to be most simple, affordable, safe surgery without any insertion of implants. A prospective study based on 30 knees with medial compartment knee osteoarthritis treated surgically in department of Orthopaedics for a period of 2 years. The data was collected using structured proforma, consent and functional outcome analysed based on Visual Analogue Score and American Knee Society Score. They were evaluated using Visual Analogue Score which was decreased from pre op 7.52 to post op 3.2 and American Knee Society Score which improved from pre op 44.9 to post op 74.1 where Good outcome was found in 23 knees (76.6%), excellent outcome was found in 3 knees (10%), fair outcome was observed in 4 knees (13.33%). Only 2 out of 30 knees had EHL weakness as complications which eventually recovered completely by end of 12 months.

Knee osteoarthritis (KOA) accounts for nearly four-fifths of osteoarthritis (OA) worldwide and increases with obesity and age¹Osteoarthritis (OA) is one of the most common causes of pain and disability, representing a significant burden for the individual and for society
Methods: A community based cross sectional study was conducted to find out the prevalence of Knee Osteoarthritis among rural population of age group above 40 years and also to find out the association between risk factors and prevalence of Knee OA with the sample of 370 by simple random sampling
Result: The prevalence of  knee osteoarthritis was found to be 31.6% in our study The  prevalence was found to be highest in the age group70 and above. The prevalence  of knee OA in females was more than the males. The lifestyle risk factor like DM and BMI ≥25 was found to be significantly associated with knee OA. (p <0.05).
Conclusion:The prevalence of knee osteoarthritis was found to be highest among elderly (>70) population, more common in females, significantly associated with obesity

Higher prevalence and growing burden of knee Osteoarthritis (OA) combined with recent safety concerns about pharmacological interventions has increased demand for new effective technologies for its management. Need of the hour is an innovative treatment alternative which may repair cartilage damage rather than just reduce symptoms of pain. Hyaluronic acid (HA) and PRP has been shown to relieve pain and symptoms as well as slow the progression of disease as stand-alone therapy. Treatment combining these modalities could be particularly hopeful owing to their positive and diverse interaction among themselves. Combinational treatment using both PRP and HA was performed on a series of 12 patients with early stage primary knee OA who fulfilled all the designated inclusion and exclusion criteria. All the patients were evaluated before and after treatment (1, 3, 6 and 12 months) by physical examination, assessment of VAS for pain, WOMAC, IKDC, KOOS and OKS to record the patient-reported improvement in pain, functionality and quality of life (QOL). 2-tailed Mann Whitney U Test was performed to assess the effect of treatment at different follow-up times of all the clinical scores. Whereas, Pearson correlation coefficient was done to evaluate the correlation between different clinical scores. For all tests, p < 0.05 was considered significant. All patients showed statistically significant improvement in all orthopedics scores evaluated. VAS score was improved significantly from 3.00 ± 0.49 at baseline to 1.57 ± 0.41 (p = 0.031) in Grade I and 3.60 ± 0.51 at baseline to 2.10 ± 0.29 (p = 0.031) in Grade II patients at 6 months’ follow-up respectively. Other scores followed similar trends with statistically significant improvement at 6 months’ follow-up which maintained throughout till end of the study period. All patients treated experienced strong functional improvement and substantial gains in pain relief, functionality and QOL. Hence our preliminary findings suggest that combined PRP and HA procedure is safe and potentially efficacious, which merits further investigation in large clinical settings and also in controlled clinical trials with long-term follow-ups. Focal Points Bench side: Platelet Rich Plasma (PRP) deliver a large pool of signalling proteins including growth factors and cytokines to the local milieu driving the tissue regeneration and repair mechanisms which when combined with high molecular weight cross-linked hyaluronan could bestow greater viscoelastic properties and alleviate the symptoms of osteoarthritis. Bedside: Osteoarthritis (OA) is a chronic degenerative disease and there is no cure for OA except medical management and partial/total knee replacement in advanced stage. PRP along with HA could have the therapeutic potential to promote cartilage regeneration and inhibit inflammation synergistically by decreasing the friction coefficient and minimizing wear. Community: The burden of OA on quality of life, disability and health care utilization is quite high. Combined PRP and HA could be an effective single-dose treatment modality restoring the functional activities and considerably reducing effective cost of the treatment. Governments and regulatory agencies: The technology to obtain PRP is FDA-approved and its safety and efficacy has been well established through several clinical studies. Regulatory agencies should consider the evidences put forth by the researchers and sanction grants to investigate in larger clinical settings and also in controlled trials with different ethnicities with long-term follow-ups.