Online ISSN: 2515-8260

Keywords : systemic lupus erythematosus

Fractalkine (CX3CL1) as a Diagnostic Marker for Childhood Onset Systemic Lupus Erythematosus

Alshymaa A. Ahmed; Ebtehag H. Hassan; Hany Elsayed; Asmaa M. Alhussiny

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2453-2463

Background: - more specific, sensitive, and in the same time non-invasive indicators for the early prediction of juvenile SLE are required.
Aim: - to evaluate serum fractalkine (CX3CL1) as a diagnostic marker, predictor of nephritis, and indicator of disease activity in pediatric SLE.
Methods: - study included 41 children newly diagnosed with SLE, age ranged from 5 to 18 years, 24 (58.5%) were presented lupus nephritis “diagnosed by renal biopsy”. A total of 20 healthy age and sex matched children were included as controls. Serum Fractalkine levels were measured using human CX3CL1 ELISA.
Results: - Serum Fractalkine were significantly higher in SLE patients (median = 1323, range 591- 16547 IU/ml) than healthy controls (median = 950, range 591- 1583 u/ml) p=0.001. Serum Fkn can be a significant diagnostic marker for juvenile lupus indicated by the are under the ROC curve, AUC = 0.81 (95% confidence interval [CI], 0.70-0.92, P<0.001), at the level 1213 IU/ml serum Fkn detected SLE with sensitivity 0.78 (95% CI, 0.62 - 0.89), specificity 0.91 (95% CI, 0.71 – 0.99), positive predictive value 0.94 (95% CI, 0.80 – 0.98), negative predictive value 0.67 (95% CI, 0.55- 0.80), and accuracy 0.82 (95% CI, 0.71 – 0.91). Serum levels of Fkn showed no statistically significant differences when compared in patients with lupus nephritis against patients without nephritis, and was not correlated with disease activity.
Conclusions: - Serum level of Fractalkine can be a diagnostic marker for childhood onset SLE either with or without lupus nephritis, with no significant correlation with activity status or the stage of LN.

Generalized Discoid Lupus Erythematosus (DLE) with Systemic Lupus Erythematosus (SLE) in Pregnancy: Case Report

Dr. Gardenia Akhyar; Dr. IrdawatyIzrul; Dr. SherlyBirawati

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 652-656

GENERALIZED DLE: Patients with generalized discoid lupus erythematosus are at a higher risk of progressing to systemic disease than those with a localized variant. Pregnancy is one of the factors that can trigger lupus erythematosus. There are only one case report published in online search that presented generalized discoid lupus erythematosus in pregnancy. We report a case of 24 year old female patient with 31-32 weeks of gestational age complained blackreddish patches accompanied by fine scales, slightly itchy and a little painful on the forehead,
cheeks, bridge of the nose, chin, ears, neck, chest, stomach, back, upper and lower extremities since ± 2 months before. ANA profile with positive result. The results of histopathologicaland dermoscopyexamination suitable with discoid lupus erythematosus. Results of the internal medicine department revealed a diagnosis of systemic lupus erythematosus. CONCLUSION:Management of DLE aims to improve general condition of patient, control the lesions, prevent of the development of further lesions; fetal growth abnormalities; preterm birth; neonatal lupus and fetal death.

Efficacy of Cyclophosphamide and Mycophenolate Mofetil Based Induction Therapy in Egyptian Patients with Systemic Lupus Erythematosus-associated Nephritis

Reham Abd- Elkhalek; Hala A Gaballah; Ola A Hussein; Marwa M El- Mosely; Shimaa M Abd El-Wahab

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 2672-2679

Background: Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus. Induction immunosuppression can include high dose cyclophosphamide (NIH protocol), low dose cyclophosphamide (Euro-lupus protocol) or mycophenolate mofetil (MMF). We aimed to assess the efficacy and safety of the 3 induction regimens in
Egyptian patients with LN.

An Unusual Presentation of Systemic Lupus Erythematosus as Evan Syndrome: A Case Report and Review Literature

Ali Al Bshabshe; Hamdan Al-Shehri; Ali Assiri; Abdulmoneim Jamil

European Journal of Molecular & Clinical Medicine, 2018, Volume 5, Issue 1, Pages 37-40

Evans syndrome is a rare autoimmune disorder with an unknown etiology. In this paper, we report the case of a 32-year-old Saudi woman living with Evans syndrome for more than 8 years (post-splenectomy) who was also diagnosed with systemic lupus erythematosus (SLE). She was admitted to our Hospital with severe headache and confusion due to cerebral venous thrombosis. The major hematologic manifestations of SLE were pancytopenia and the antiphospholipid syndrome, which are indicators of disease activity when all other possible causes are excluded. The patient was treated with anticoagulation and immunosuppressive therapy and subsequently showed significant improvements in thrombosis, thrombocytopenia, and anemia. This case report provides an overview of the association between Evan syndrome and SLE.