Online ISSN: 2515-8260

Keywords : Recurrence


TO STUDY THE COMPLICATIONS AND CAUSES OF INCISIONAL HERNIA REPAIR WITH PREPERITONEAL MESHPLASTY

Manoj Kumar Sharma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 456-459

Aim: The aim of this study to determine the complications and causes of incisional hernia repair with preperitoneal meshplasty.
Material and methods: Fifty patients hospitalised with the diagnosis of incisional hernia to various surgical wards underwent open preperitoneal polypropylene mesh surgery. Six months to one year after surgery, it was reviewed for problems and recurrence, and the findings were recorded. Incisional hernia patients were included in this research if they were between the ages of 14 and 77.
Results: There were 40 female patients and 10 male patients among the 50 total. In terms of defect size, 12 patients had less than 2 cm, 34 patients had between 2.1-4 cm, 2 patients had between 4.1-6 cm, and 2 patients had between 6.1-8 cm. Infraumbilical hernia was found in 39 cases, whereas supraumbilical hernia was found in 11 patients. In terms of post-operative complications, four patients experienced seroma, two had edge necrosis, two had post-op ileus, and two had persistent discomfort. Six patients were followed for six months, twelve for nine months, and thirty-two for a year.
Conclusion: The current research found that open preperitoneal polypropylene mesh repair has much less postoperative problems compared to other mesh repair procedures, and that there was no recurrence among its individuals throughout the follow-up period.

A Prospective Study Evaluating Correlation Between Preoperative Histopathology And Morphologywith Recurrence Of PterygiumAfter CLAU Surgery

Dr. Neetu Kori Shankhwar, Dr. Shweta Walia, Dr. DivyaKhandelwal, Dr. V. Bhaisare, Dr. Preeti Rawat, Dr. Manushree Sharma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 317-323

Aim- To observe recurrence rate after conjunctival limbal autograft (CLAU) and tocorrelate
this with preoperative histopathological and morphologicalcharacteristics of pterygium.
Design: Interventional, Prospective, Hospital-Based Study.
Methods: 107 patients with primary pterygium were examined, managed by CLAU and
histopathology sample sent. The outcomes were assessed in terms of clinically significant or
insignificant recurrence till 6 months follow-up.
Results: 57% patients were female. 17.8% participants had Stockers Line and all patients
having stocker’s line had stationary type of pterygium. Fuchs spots were seen in 4.7% of
patients. Histopathology findings includeEpithelial Hyperplasia (80.4%), Vascularity
Overwhelms Fibrosis (39.1%), Vascularity Similar to Fibrosis (28.3%), Fibrosis Overwhelms
Vascularity (34.8%), Perivascular Stromal Inflammation (54.3%), Diffuse Stromal
Inflammation (37.0%). The following variables were significantly associated (p<0.05) with
the Recurrence: Age, Fuchs Spots, higher vascularity and Diffuse Stromal Inflammation on
histopathology.
Conclusion: Factors such as younger age group,higher redness and thickness of pterygium,
Fuchs Spots, higher vascularity and diffuseinflammation on histopathological examination
can be considered as a risk factor for recurrence. However, occupation, laterality, location
and type of pterygiumwere found not to be related to recurrence.

Role of Modified Bascom Procedure in the Treatment of Pilonidal Sinus

Naveen Banoth, Venkatesh A

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2428-2434

Background:An infection of the natal cleft and sacrococcygeal area that affects mostly teenagers and young adults. The biggest disadvantage is wound healing. The lack of a superior surgical procedure is due to the numerous proposed surgical techniques. The study will describe the modified Bascom procedure and its effects in individuals with pilonidal illness. Objectives:The purpose of this study is to evaluate the modified Bascom procedure and its results in patients with pilonidal disease.
Materials and Methods: From October 2020 to May 2021, patients presenting to JSS Hospital, Mysuru with pilonidal sinus were studied prospectively. Patient selection is based on a thorough history, physical examination, and basic pre-operative examinations. Thirty cases receive modified Bascom. The patient's rate of cure, postoperative complications, and recurrence are observed.
Results: In this study of 20 patients, there was a 9:1 male preponderance. 20.46 + 9.42yrs mean age of presentation Pilonidal sinus is widespread in persons who sit for long periods of time as drivers, students, etc. Acute pilonidal sinus to chronic discharge sinus. These patients' hospital stay, healing time, wound infection, wound dehiscence, and recurrence were evaluated, and the results were favourable. Our patients had wound infection and dehiscence, although the rate of recurrence and complications, hospital stay (4.42 + 1.24 days), and wound healing time (19.6 + 1.22 days) was low compared to previous operations.
Conclusion: Study demonstrates pilonidal illness affects guys in their 30s and 40s. Occupation and local anatomical factors play a role in illness development. Pilonidal disease is diagnosed clinically. There are several options for treating pilonidal disease. The primary closure is the most effective, with low recurrence rates, less problems, and faster healing

A comparative study of onlay and pre-peritoneal open mesh repair in the management of umbilical hernia in adults

Dr. Sreekaraswamy R, Dr. HC Chaluvanarayana, Dr. Sujay C, Dr. Varun Byrappa

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1655-1659

Introduction: Umbilical hernias in adults are commonly acquired hernias. These are more common in women, and in conditions like pregnancy, ascites, obesity etc. More than 1 million hernia surgeries are done annually in India. Suture repair techniques have dominated ventral and incisional hernia repair over a century. The most popular of these techniques was the Mayo duplication. In larger hernias, suture repair requires the application of tension to the fascia in order to close the orifice.
Objectives of the study: To evaluate the outcome of onlay and pre-peritoneal open mesh repair in umbilical hernias in adults regarding operative time, ease of procedure, hospital stay, complications and recurrence if any.

TREATMENT OF PILONIDAL SINUS BY DIFFERENT METHODS

Hatem Mohammad Abdelmoneim, Samir Ibrahim Mohammed, Yousef Mohmmed Abdallah, Mahmoud Abdou Yassin, Mohammed Abdallah Zaitoun

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 4914-4924

Background: The ideal operation for pilonidal sinus disease should be a simple one with low complication and low recurrence rates. This is achieved by flap techniques which flatten the natal cleft with an off-midline closure. The aim of the present study to determine the better procedure in treatment of pilonidal sinus disease, compare the efficiency and short-term results of conservative treatment, open excision, Karydakis flap and Rhomboid flap in treatment of pilonidal sinus disease. Patients and methods: A randomized controlled study included 56 patients with pilonidal sinus disease were admitted to General Surgery Department, Zagazig University Hospitals. The patients were allocated equally into: group (1) were treated with conservative method with medical treatment and drainage if needed; group (2) were operated by open technique; group (3) were operated by Limberg flap technique and group (4) were operated by Karydakis technique. Patients were subjected to full history and clinical examination, preoperative investigations and postoperative assessment. Results: The present study showed no significant difference regard age distribution as age was distributed as 30.71±5.73, 32.21±6.58, 32.57±6.47 and 32.42±8.2 respectively among groups. Conservative group was significantly shorter duration of symptoms than other groups with no significant difference. Operative time was significantly longer among Limberg group than Karydakis group and finally open group as it was significantly shorter than other group. Visual analog scale (VAS) was significantly higher among open cases. Healing and return work were significantly higher among open groupg compared to other groups. Recurrence was significantly associated with open and conservative groups while there was only one case in Limberg Group and no case in Karydakis Group. Bad and good satisfaction were significantly associated with open and conservative groups while excellent was significantly associated with Limberg Group & Karydakis Group. Conclusion: The four techniques are effective in treatment of pilonidal sinus while Conservative is preferred at early stage of the disease and flap techniques has better results and satisfaction than Open one. The Karydakis flap is prefered the Limberg flap for treating uncomplicated Sacrococcygeal pilonidal disease due to shorter operative and healing time with superior patient satisfaction.

RECURRENT OVARIAN CANCER: MECHANISMS OF DEVELOPMENT OF PERITONEAL MALIGNANT ASCITES

Bunyod Saidkulov; Jurabek Abduraxmonov; Rahimov M. Nodir; Farkhod Raufov

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2423-2428

Diagnostic approach and treatment of recurrent ovarian cancer has many
unresolved issues, the relevance of which is associated with late diagnosis and ultimately
low treatment effectiveness and high mortality rates. The clinical manifestation of
recurrent ovarian cancer is variable even within a morphologically similar group of
patients due to the high degree of heterogeneity of the tumor. Questions remain about how
wide the range of molecular genetic markers is and what is the correlation between their
level and the effectiveness of treatment for ovarian cancer recurrence. One of the most
promising ways to obtain information about the nature of the recurrence of the tumor
process in ovarian cancer (OC) can be the study of ascitic fluid (AF).

Leukemia Recurrence Exclusively in the Breast after Stem Cell Transplant

Naziya Samreen; Shahrukh K. Hashmi; Amy Lynn Conners; Asha Bhatt; Katrina N. Glazebrook

European Journal of Molecular & Clinical Medicine, 2018, Volume 5, Issue 1, Pages 41-45

Introduction: Leukemic involvement of the breast is extremely rare but constitutes an oncologic emergency. Imaging findings of T-Cell acute lymphoblastic leukemia (T-ALL) recurrence in the breasts have not been previously described. Case Description: Patient is a 25 year old female who presented with symptoms of superior vena cava (SVC) obstruction secondary to a mediastinal mass status post biopsy demonstrating T-ALL, which was cluster of differentiation 3 (CD3) positive and B-cell lymphoma 2 (BCL-2), and 80% Ki-67 positive. She was treated with chemotherapy and post-treatment positron emission tomography/computed tomography (PET/CT) demonstrated resolution of mediastinal mass, with no evidence of distant disease. She underwent allogeneic hematopoietic stem cell transplant (HSCT) in first remission. Seven months post-HSCT, patient presented with a large area of tender swelling of both the breasts with biopsy demonstrating relapsed T-ALL. Radiologic findings showed bilateral breast masses on ultrasound and mammogram, which were hypermetabolic on PET/CT. Conclusions: Breast involvement in leukemia recurrence, a very rare entity, can present with palpable masses. Mammographic findings in leukemia can include masses or architectural distortion, they are typically hyperechoic on ultrasound, and can have marked uptake on PET/CT. Oncologists, primary care providers and radiologists should be aware of leukemia presentations in the breast for prompt referral for urgent management.