Online ISSN: 2515-8260

Keywords : breast


TO STUDY AND COMPARE THE VARIOUS MODALITIES OF EVALUATION OF PRIMARY BREAST CANCER SIZE

Dr. Brajesh Pathak, Dr. Vibhor Mahendru

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 2700-2707

The ensuing driving force behind death from breast cancer in women is legitimacy. It occurs when cells in the breast become confined and attack the supporting tissue or spread throughout the body. Mammography is a truly unprecedented and remarkable modality used to distinguish and find breast cancer in a short time frame.
Mammography is a two-stage picture and depends on the unambiguous confirmation of dangerous morphological deviations for breast cancer. These manifestations combine areas of mass, all calcification, gap and required curvature. A standard screening mammogram combines the mean diagonal and craniocaudal approach on each breast. Screening tests are facilitated only to find unsafe disclosures after which the woman will return for a more conclusive method. Positive mammographic approaches can likewise incorporate spot pressure, enlargement, rolling, extended view, and upright view to delineate and bind features.

TO COMPARE THE SENSITIVITY AND SPECIFICITY OF THE TRADITIONAL TRIPLE ASSESSMENT OF SYMPTOMATIC BREAST LESIONS WITH CONTRAST-ENHANCED DYNAMIC MAGNETIC RESONANCE IMAGING.

Dr. Manoj Srivastava, Dr. Nishee Srivastava

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2613-2616

Background & Method: The aim of this study is to compare the sensitivity and specificity of the traditional triple assessment of symptomatic breast lesions with contrast-enhanced dynamic magnetic resonance imaging. patients with palpable breast lesions were recruited from the symptomatic breast clinics. All underwent clinical examination by consultant breast surgeons, FNAC was performed according to our standard protocol for symptomatic patients, which does not include image guidance.
 
Result: MRI proved to most sensitive and specific modality. Triple assessment MRI and FNAC all have specificity of 100%. MRI proved to be most sensitive modality with 96 % sensitivity, (physical examination 91%, USG 91%, FNAC 84% and Triple assessment 84 %.)
 
Conclusion: With the aim of improving the accuracy of triple assessment, MRI can provide valuable information and with improvements in technology can further enhance specificity. Contrast-enhanced dynamic magnetic resonance imaging of the breast is as sensitive and more specific than the combined traditional triple assessment for the diagnosis of malignant breast lesions.

Leukemia Recurrence Exclusively in the Breast after Stem Cell Transplant

Naziya Samreen; Shahrukh K. Hashmi; Amy Lynn Conners; Asha Bhatt; Katrina N. Glazebrook

European Journal of Molecular & Clinical Medicine, 2018, Volume 5, Issue 1, Pages 41-45

Introduction: Leukemic involvement of the breast is extremely rare but constitutes an oncologic emergency. Imaging findings of T-Cell acute lymphoblastic leukemia (T-ALL) recurrence in the breasts have not been previously described. Case Description: Patient is a 25 year old female who presented with symptoms of superior vena cava (SVC) obstruction secondary to a mediastinal mass status post biopsy demonstrating T-ALL, which was cluster of differentiation 3 (CD3) positive and B-cell lymphoma 2 (BCL-2), and 80% Ki-67 positive. She was treated with chemotherapy and post-treatment positron emission tomography/computed tomography (PET/CT) demonstrated resolution of mediastinal mass, with no evidence of distant disease. She underwent allogeneic hematopoietic stem cell transplant (HSCT) in first remission. Seven months post-HSCT, patient presented with a large area of tender swelling of both the breasts with biopsy demonstrating relapsed T-ALL. Radiologic findings showed bilateral breast masses on ultrasound and mammogram, which were hypermetabolic on PET/CT. Conclusions: Breast involvement in leukemia recurrence, a very rare entity, can present with palpable masses. Mammographic findings in leukemia can include masses or architectural distortion, they are typically hyperechoic on ultrasound, and can have marked uptake on PET/CT. Oncologists, primary care providers and radiologists should be aware of leukemia presentations in the breast for prompt referral for urgent management.