Online ISSN: 2515-8260

Keywords : brain

Surgical management of posterior fossa tuberculosis

Dr. K Narasimha, Dr. Sujay Kumar Parasa, Dr. Ashok Kumar Kothapalli

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 3131-3137

Tuberculoma of the brain is a dangerous disease that is becoming more common in developed countries as tuberculosis continues to spread. At first, antimycobacterial drugs are used to treat brain tuberculoma. But neurosurgery is the main part of treatment. Surgery is needed if the tuberculoma does not respond to medical treatment, if it is causing symptoms, or if there is no other way to find out what is wrong. In this paper, we talk about four cases of posterior fossa tuberculomas in people who had never had tuberculosis or a weak immune system before. Brain tuberculosis had to be treated with surgery in all cases for it to go away safely and effectively.

Role of brain imaging using CT/MRI in diagnosis and management of stroke

Dr.Aarish Bali,Dr.Mridul Arora,Dr.Karanpartap Singh, Dr.Venus Garg, Dr. Kiran Kumar Singal, Dr. SS Kaushal

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 1073-1077

Introduction: Prevalence of morbidity and mortality is keep rising in poorly managed stroke
cases. Early detection and proper diagnosis have great potential in management of stroke. The
development of brain imaging modalities (CT/MRI) have led to a milestone that provides a
living autopsy of the brain.
Objective: The goal of this prospective study is to determine the clinical efficacy of CT/MRI
and its benefits over traditional techniques of clinical diagnosis in stroke patients.
Methods: 50 patients in whom clinical signs of stroke i.e., slurring of speech, weakness on
one side of the body, deviation of angle of mouth, and neurological deficits observed were
recruited in the study. CT/MRI was used to diagnosed the stroke.
Results:The NCCT finding have revealed Diffused cerebral atrophy in 14 (28%) patients,
Chronic Infarct in 11 (22%) patients, Subacute Infarct in 7 (14%) patients, Acute Infarct in 6
(12%) patients and Encephalomalacia in 2 (4%) patients whereas 10 (20%) patients
underwent MRI brain.The MRI brain finding have revealed Diffused cerebral atrophy in 6
(6%) patients, Chronic Infarct in 1 (2%) patient, Subacute Infarct in 4 (8%) patients, Acute
Infarct in 3 (6%) patients and Encephalomalacia in 2 (4%) patients whereas 37 (74%) patients
underwent NCCT head.
Conclusion: In both NCCT head and MRI brain finding have revealed diffuse cerebral
atrophy as the most common finding among recruited patients followed by the chronic infarct
(22%), subacute infarct (14%), acute infarct (12%) and encephalomalacia (4%).

The Possible Protective Effect Of Saffron Against Acrylamide-Induced Neurotoxicity In Albino Rats (A Molecular Study)

Ahmed A. Algazeery; Samir A. Nassar; Abdel-Rahman S. Ballah

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 2311-2327

Nowadays, there is a continuous and progressive global public exposure to acrylamide (ACR) due its presence in fried and backed food. Thermal preparation of sugar-rich food mostly initiates chemical reactions that yield dangerous chemicals. Of these chemicals arise acrylamide and its metabolite glycidamide. Those having a high
affinity for binding to nervous tissues. The acrylamide-induced neurotoxicity involves reduction in proliferation of neuronal progenitor cells associated with apoptotic cell death. Concerning acrylamide-induced toxicity, preventive medicine research focused on natural antioxidants. Studies on active constituents of Saffron showed obvious antioxidant, and anti-toxic properties. Here, we designed this study to investigate the possible protective
effect of saffron against acrylamide-induced neurotoxicity in hippocampal area of brain. Adult male albino rats were assigned equally into 4 groups (n = 8); control; saffron group; acrylamide (ACR)-administered group and combined ACR and saffron- treated group. Our results recorded molecular changes as a significant decrease on genomic DNA fragmentation in saffron co-administered group as compared to ACR-exposed group. The changes on DNA mutagenicity were studied by analyzing the random amplification of polymorphism of DNA that showed an elevated genomic integrity on rat co -administered saffron with ACR in contrast to those exposed to ACR only.

Stopping Power For Carbon, Oxygen And Proton Interacting With Adipose Tissue, Skeletal Muscle And Brain Using Different Formulas

Ahlam Habeeb Hussien

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 494-503

In this research , the energy loss of electronic to projected carbon, oxygen and protons were calculated in targets (Adipose tissue, Skeletal muscle, and Brain)With using Bohr equation and Bethe equation with Bloch correction and Shell correction at the energy range of (20_500) MeV . The calculations were compared with the experimental data of the SRIM 2012 .Since Bohr equation is classic, its results were a difference from the results of the practical program. As for Bethe's quantum equation, its results were Bloch correction that was closest to the practical program. As for the shell correction, it recorded a difference at specific energies and then began to approach with increasing range of used energy.


Jawwad Sami Ur Rahman, Sathish Kumar Selvaperumal, Rajasvaran Logeswaran

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 9144-9155

In this paper, a proposed hybrid algorithm using K-means and Fuzzy logic for brain segmentation, is developed, simulated and evaluated. The system identifies the white matter, gray matter and Cerebrospinal Fluid (CSF). The proposed system was tested using Magnetic Resonance Imaging (MRI), and evaluated in terms of the misclassification rate and percentage of clustering. The misclassification rate was found to be lesser in the proposed system as compared to the existing systems using K-means and Fuzzy logic. Further, the percentage of clustering is improved by the proposed system as compared to the existing algorithms. This work paves the way for future development of Neuro Fuzzy K-means algorithm in order to reduce the misclassification rate further in clustering the white matter, gray matter and CSF.

Isolated Demyelination of Corpus Callosum Following Hypoxia

Lucio Marinelli; Lara Castelletti; Carlo Trompetto

European Journal of Molecular & Clinical Medicine, 2018, Volume 5, Issue 1, Pages 85-88

Corpus callosum includes a large amount of axons with various degrees of myelination, interconnecting cerebral hemispheres. Tumors, demyelinating diseases, infections, trauma and metabolic diseases as well as vascular lesions may affect corpus callosum, often extending to other white matter areas of the brain. We describe the case of a 76 years old male patient with history of arterial hypertension, diabetes mellitus and normal pressure hydrocephalus, developing dysphagia during hospitalization. Ab-ingestis pneumonia caused brain hypoxia and coma; brain magnetic resonance disclosed isolated demyelination of corpus callosum that was not present before hypoxia. Compared to neurons and astrocytes, oligodendrocytes are reported as particularly sensitive to hypoxia. Respiratory involvement without blood flow impairment could have lead to a prevalent oligodendrocytes damage, resulting in a selective demyelination of corpus callosum. Our patient indeed evolved into persistent vegetative state and died five months after hypoxic episode. This case report could give some insight about in vivo brain susceptibility to hypoxic damage.