Online ISSN: 2515-8260

Keywords : hypoxia


Hilola Fayzullaeva; Oksana Kim; Zarifa Saidmurodova; Kakhhor Halikov; Muhiba Abdullaeva

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2370-2374

The protection of motherhood and childhood is a priority area of health care in
our Republic; this provision is enshrined in fundamental government documents,
programs for reforming the health system, and a program for creating a healthy
generation. According to the International Consensus on Resuscitation of the Newborn,
more than a million newborns die every year in the world, and in 19% of cases the cause of
death is asphyxiation

Isolated Demyelination of Corpus Callosum Following Hypoxia

Lucio Marinelli; Lara Castelletti; Carlo Trompetto

European Journal of Molecular & Clinical Medicine, 2018, Volume 5, Issue 1, Pages 85-88

Corpus callosum includes a large amount of axons with various degrees of myelination, interconnecting cerebral hemispheres. Tumors, demyelinating diseases, infections, trauma and metabolic diseases as well as vascular lesions may affect corpus callosum, often extending to other white matter areas of the brain. We describe the case of a 76 years old male patient with history of arterial hypertension, diabetes mellitus and normal pressure hydrocephalus, developing dysphagia during hospitalization. Ab-ingestis pneumonia caused brain hypoxia and coma; brain magnetic resonance disclosed isolated demyelination of corpus callosum that was not present before hypoxia. Compared to neurons and astrocytes, oligodendrocytes are reported as particularly sensitive to hypoxia. Respiratory involvement without blood flow impairment could have lead to a prevalent oligodendrocytes damage, resulting in a selective demyelination of corpus callosum. Our patient indeed evolved into persistent vegetative state and died five months after hypoxic episode. This case report could give some insight about in vivo brain susceptibility to hypoxic damage.