Online ISSN: 2515-8260

Keywords : hypoxia


CLINICAL AND EPIDEMIOLOGICAL PROFILE OF COVID-19 PATIENTS ADMITTED AT A TERTIARY CARE CENTRE OF NORTH INDIA

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 4748-4759

Background & objectives: The COVID-19 pandemic emerged as a major public health emergency affecting the healthcare services all over the world. It is essential to analyse the epidemiologicalandclinicalcharacteristicsofpatientswithCOVID19indifferentpartsofourcountry.Thisstudyhighlights clinical experience in managing patients with COVID-19 at a tertiary care centre in northernIndia.
Methods:Clinicalcharacteristicsandoutcomesofconsecutiveadultpatientsadmittedtoatertiarycare hospitalatAll India Institute of medical Sciences, Patna, Bihar,India,from August12020 toJanuary 31,2021werestudied.ThediagnosisofSARS-CoV-2 infection was confirmed by real-time reverse transcriptase polymerase chain reaction (RT-PCR) on throat and/or nasopharyngeal swabs. All patients were managed according to the institute’s consensus protocol and in accordance with Indian Council of Medical Researchguidelines.
Results: During the study period, 283 patients with SARS-CoV-2 infection were admitted. The history of contact with COVID-19-affected individuals was available in only29 patients. The median age of the patients was 53.85 years (15-95 years), and there were 217 (76.67 %) males. Of the total enrolled patients, only 19 patients (7%)were asymptomatic and rest 264 patients (93%) were symptomatic.Thecommonpresentingcomplaintswerefever in 231 patients(81 %),cough in 217 patients(76 %) and shortness of breath in 204 patients (72%). Out of 283 patients enrolled for the study, 113 patients (39%) had Hypertension as an accompanying comorbid illness, 122 (43%) had Diabetes mellitus, CKD and Hypothyroidism each in 8% of patients, CAD & COPD in 7% and 6% patients respectively
Agemorethan60yearsandpresenceofdiabetesandhypertensionweresignificantlyassociatedwith severeCOVID-19disease.Mortalityof 65 patients ( 23%) wasobserved.
Interpretation&conclusions:MajorityofthepatientswithCOVID-19infectionpresentingtoourhospital were elderly and symptomatic. Fever was noted only in three-fourth of the patients and respiratory symptoms in more than half of the enrolled patients. Patients with comorbidities were more vulnerable to complications. Certain Inflammatory markers like serum CRP, Ferritin, LDH, & D-Dimer have define prognostic value. Triaged classificationofpatientsandprotocol-basedtreatmentresultedingoodoutcomesandlowcasefatality.

METABOLIC STATUS AS AN INDICATOR OF POST-HYPOXIC COMPLICATIONS IN NEWBORNS BORN IN ASPHXIA

Hilola Fayzullaeva; Oksana Kim; Zarifa Saidmurodova; Kakhhor Halikov; Muhiba Abdullaeva

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2370-2374

The protection of motherhood and childhood is a priority area of health care in
our Republic; this provision is enshrined in fundamental government documents,
programs for reforming the health system, and a program for creating a healthy
generation. According to the International Consensus on Resuscitation of the Newborn,
more than a million newborns die every year in the world, and in 19% of cases the cause of
death is asphyxiation

Isolated Demyelination of Corpus Callosum Following Hypoxia

Lucio Marinelli; Lara Castelletti; Carlo Trompetto

European Journal of Molecular & Clinical Medicine, 2018, Volume 5, Issue 1, Pages 85-88

Corpus callosum includes a large amount of axons with various degrees of myelination, interconnecting cerebral hemispheres. Tumors, demyelinating diseases, infections, trauma and metabolic diseases as well as vascular lesions may affect corpus callosum, often extending to other white matter areas of the brain. We describe the case of a 76 years old male patient with history of arterial hypertension, diabetes mellitus and normal pressure hydrocephalus, developing dysphagia during hospitalization. Ab-ingestis pneumonia caused brain hypoxia and coma; brain magnetic resonance disclosed isolated demyelination of corpus callosum that was not present before hypoxia. Compared to neurons and astrocytes, oligodendrocytes are reported as particularly sensitive to hypoxia. Respiratory involvement without blood flow impairment could have lead to a prevalent oligodendrocytes damage, resulting in a selective demyelination of corpus callosum. Our patient indeed evolved into persistent vegetative state and died five months after hypoxic episode. This case report could give some insight about in vivo brain susceptibility to hypoxic damage.