Online ISSN: 2515-8260

Keywords : Chemotherapy


Evaluation of Post-operative wound complications in patients getting neoadjuvant chemotherapy

Sumitoj Singh; Ashok Kumar; Yahya K.P; Vandana Sidhu

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2526-2534

Aim: To analyse the post-operative wound complications in patients getting neoadjuvant
chemotherapy in respect to those patients who underwent surgery without any neoadjuvant
chemotherapy.
Material and method: The present prospective observational study was conducted in
GMCH AMRITSAR Punjab.It consisted of 50 female patients admitted with breast
carcinomadivided into group of 25 each, one group that received neoadjuvant
chemotherapy and the other group which underwent surgery first.
Results: The mean age of the patients was 50.16±11.57 years. no significant difference was
observed in age, wound complications, healing time between the two groups. Flap necrosis
was seen in 4% cases and 12% cases in group 1(primary surgery) and 2(NACT)
respectively. Seroma was seen in 16% and 8% cases in group 1 and 2 respectively. 12%
cases of group 1 and 20% cases of group 2 presented with wound infection. Patients with
DM presented with more complication in both the groups. The difference between both the
groups was significant which shows that diabetic patient without NACT have more risk of
developing wound complications than with NACT.No significant difference was observed
between the mean of healing time in both the groups .
Conclusion:In conclusion, our study revealed that a factor, like diabetes mellitus was
associated with an increased risk of wound complications for patients undergoing
mastectomy. However, neoadjuvant chemotherapy was not associated with an increased
risk of wound complications.

The Role of Oncology Pharmacists in optimizing patient care in Chronic Immune Thrombocytopenia

Bedanta Bhattacharjee; Bhargab Deka; Nasima Ahmed; Bonti Sonowal; Arzoo Newar; Ashique Ahmed; Abu Md Ashif Ikbal; Amlanjyoti Rajkhowa; Alakesh Bharali; Gargi Das; Ritu Bharti; Ripon Sinha

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 279-292
DOI: 10.31838/ejmcm.08.03.27

Immune thrombocytopenia or ITP is an autoimmune disorder in which the body creates autoantibodies against its thrombocytes or platelets that are destroyed, resulting in purpura or minor bleeding spots under the surface. It is most often found in cancer patients and is of growing concern.While the main causes of thrombocytopenia in cancer pat ients are chemotherapy and radiation, other aetiologies should also be considered in patients suffering
 from this debilitating disease. Thrombocytopenia causes a variety of complications in the treatment of cancer patients and therefore pharmacists need to be familiar with epidemiology, pathophysiology, risk factors, diagnostic methods, and emerging therapeutic options for chronic immune thrombocytopenia to help oncologists identify and implement realistic treatment measures for chronic immune thrombocytopenia patients undergoing cancer treatment.The objective of this review is to provide a brief overview of chronic immune thrombocytopenia and various strategies for the clinical management of the disease.

Post mastectomy wound complications with or without neoadjuvant chemotherapy

Sumitoj Singh; Ashok Kumar; Yahya K.P; Vandana Sidhu

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2477-2485

Aim: To analyse the post-operative wound complications in patients getting neoadjuvant
chemotherapy in respect to those patients who underwent surgery without any neoadjuvant
chemotherapy.
Material and method: The present prospective observational study was conducted in
GMCH AMRITSAR Punjab.It consisted of 50 female patients admitted with breast
carcinomadivided into group of 25 each, one group that received neoadjuvant
chemotherapy and the other group which underwent surgery first.
Results: The mean age of the patients was 50.16±11.57 years. no significant difference was
observed in age, wound complications, healing time between the two groups. Flap necrosis
was seen in 4% cases and 12% cases in group 1(primary surgery) and 2(NACT)
respectively. Seroma was seen in 16% and 8% cases in group 1 and 2 respectively. 12%
cases of group 1 and 20% cases of group 2 presented with wound infection. Patients with
DM presented with more complication in both the groups. The difference between both the
groups was significant which shows that diabetic patient without NACT have more risk of
developing wound complications than with NACT.No significant difference was observed
between the mean of healing time in both the groups .

Effect of Improving Nurses' Practices on women’s satisfaction diagnosed with Reproductive Cancer undergoing Chemotherapy

Amal Mousa Mohamed kheder; Aziza Attia; Om-Elsaad Farouk; Eman Mostafa

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 4457-4470

Background: Reproductive cancer is an important health problem since it leads to mortality and morbidity of women in all over the world. Aim: evaluate effect of improving Nurses' practices on women’s satisfaction diagnosed with Reproductive Cancer undergoing Chemotherapy. Setting: The study was conducted at Nasser institute hospital (at oncology department outpatient & inpatient department). Study design: a quasi experimental design was utilized. Sample: All nurses (40) who were working in the pre mentioned study setting during the time of the study and convenient sample,80 women with reproductive cancer Tools: Tool 1 self- administered structured questionnaire sheet, Tool 2 observational checklist, and Tool 3 Women's satisfaction questionnaire sheets. Results: showed statistically significant improvement in nurses’ practical skills related to chemotherapy administration immediately post intervention and after three month follow up phase and increase Women's satisfaction level toward care provided by nurses, study confirmed statistically a highly significant positive relation between nurses' practice and Women's satisfaction post guidelines intervention. Conclusion: nursing guideline had positive effect on nurses' practices regarding chemotherapy which had direct effect on women’s satisfaction with nursing care they received. Recommendation: Refreshing courses pre-service and in-services training programs to enhance nurse’s practical skills at oncology units. Further research is recommended to identify factors that effect on nurse’s knowledge and their practice related to oncology patient receiving chemotherapy.

Advancement in Ovarian Cancer Treatment

Samta Gupta; Archana Mehta

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 832-838

Epithelial ovarian malignant growth is ordinarily analyzed at a propelled stage. The better current class of chemotherapy treatments result in the high frequency of full reductions, however, the repetition rate is also higher. The infection eventually is a cycle of free moments and repetitive scenes in most cases. Distinctive focused on treatment draws near and natural medications, as of now being worked on, bring the guarantee of transforming ovarian malignant growth into a sensible ceaseless ailment. In this survey, we examine the present standard in the treatment for ovarian malignancy, significant late examinations on the new variations of regular treatments, and new remedial methodologies, as of late endorsed as well as in clinical preliminaries. The following also have an opponent in angiogenic drugs, polyADP-ribose polymerase (PARP), developmental factor flagging inhibitors or folate receptor inhibitors. They also address the cost-effectiveness of certain new treatments and the question of best option for personalized therapy.

LIFE-SAVING ADVANCES IN SKIN CANCER TREATMENT

Yazhlini P; Dr Jayalakshmi Somasundaram

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 350-358

AIM: This study aims to find out about life-saving advances in skin cancer treatment.
INTRODUCTION: Skin malignant diseases are those that emerge from the skin. They are due to the development of abnormal cells that can invade and spread to different parts of the body there are three types of skin cancer- basal cell carcinoma, squamous cell carcinoma and melanomas. Hereditary factors strongly influence the risk factor of skin disease and malignant growth. Basal cell malignant growth develops gradually and can harm the tissue around it, however, it does not spread to distant areas or result in death. Squamous cell skin disease is bound to spread. Melanomas are the most aggressive. Although hereditary variables may have the least impact on skin management growth, most skin cancers are caused due to exposure to UV radiation.
MATERIALS AND METHODS: Review of various scientific literature was done in preparation of the manuscript. Several databases were searched for relevant articles from pub med and Google scholar. Databases of individual journals were searched for keywords such as skin cancer, sunlight on skin cancer, treatment, advances, prevention etc. The exclusion criteria were case reports, review and studies in other languages.
CONCLUSION: From the review, we can know about many recent advances for the cure of cancer. Personalised vaccines, cell therapy, gene editing and micro-treatment are newer technologies for treating cancer. In future cancer can also become a curable disease.

Zhengyuan capsule alleviates chemotherapy-related fatigue in nude mice with human lung adenocarcinoma A549 xenografts

Jieshan Guan; Lizhu Lin; Mingzi Ouyang

European Journal of Molecular & Clinical Medicine, 2019, Volume 6, Issue 1, Pages 3-11

Aim: We aimed to investigate the action mechanism of Zhengyuan capsule (a registered proprietary Chinese medicine) against chemotherapy-related fatigue (CRF). Methods: BALB/c-nu nude mice model with human lung adenocarcinoma A549 xenografts was constructed by injection of A549 cell suspension. The xenografted mice were randomly divided into model, cisplatin and cisplatin+Zhengyuan groups (n = 20 each). The cisplatin group was given an intraperitoneal injection of 5 mg/kg cisplatin every 3 days for 21 days. The cisplatin+Zhengyuan group was given an intragastric administration of cisplatin and 25 mg/kg Zhengyuan capsule each day for 21 days. Normal control and model groups were administrated with equal amount of saline. Forced swimming assay, tail suspension test, open field test, hepatic glycogen assay, blood analysis, and bone marrow smear was performed. Results: The cisplatin group developed CRF after receiving chemotherapy. When compared with cisplatin group, the cisplatin+Zhengyuan group exhibited longer exhaustive swimming time (p

The mechanisms and challenges of cancer chemotherapy resistance: A current overview

Ravindran Ankathil

European Journal of Molecular & Clinical Medicine, 2019, Volume 6, Issue 1, Pages 26-34

Chemotherapy remains one of the principal modes of treatment for cancer patients. Despite advances in anticancer agents for multiple cancers, development of resistance to classical chemotherapeutic drugs and targeted drugs continues to be a major challenge. Drug resistance which can be either intrinsic or acquired, leads to treatment failure and tumor progression. Drug resistance occurs because of mechanisms that are associated with individual cancer cells or through mechanisms that relate to the microenvironment within tumors. Multiple molecular determinants of intrinsic and acquired resistance including genetic, epigenetic factors, as well as other factors which act at the genomic or cellular level have been identified. This review provides a conspectus on some of the recent discoveries on mechanisms of anticancer drug resistance and the possible ways to revert resistance and thereby improve cancer therapy.