Online ISSN: 2515-8260

Keywords : chemotherapy


Low Quality of life (QoL) in Indian breast cancer patients : a critical analysis of UP

Sanjiv Srivastava; Dr.Alpana Srivastava; Dr. Sandeep Tiwari

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 1561-1575

Background
Breast cancer is the commonest of all cancers among women across the world and India being no exception to this deadly disease. There may be many symptoms due to cancer, some are complex but some are not complex. Measuring quality of life (QoL) is important to measure overall burden of disease. It is important to evaluate cancer specific QoL which is associated to all stages of this disease. Also Quality of Life is a term that adds various dimensions of quality of life such as physical, psychological, socio-economical, spiritual, cognitional & social dimensions. Balance between all the four domains (i.e. Physical, Psychological, Social and Spiritual) means good quality of life, but in India QoL in general is not good and if we talk of cancer patients its worst.
Objective
The aim of this study is assessment of QoL in breast cancer patients undergoing treatment through various modalities at different stages of disease.
Methods
This is a cross-sectional study, a total of 150 breast cancer patients were included. Patients quality of life were assessed by Ferrel‘s Quality of Life Instrument-Breast Cancer patient
version and the instrument is already validated by Ferrel BR et al (2012). These questionnaires consist of general well-being, psychological well-being, distress, fearfulness, social concerns and spiritual well-being. The data obtained gives Cronbach alpha value of 0.642 which is reliable enough for further study. The QoL in for most subjects was around 50% and is a cause of concern as this is quite low as compare to global standards.
Results
A significant relationship between type of cancer, amount of pain, and fatigue (tiredness) was found. However, none of the demographic variables (age, marital status, income) were significantly related to QoL. Education and type of treatment were found to be correlated with QoL. The physical well-being score was found to be Mean = 4.82, SD = 2.19. The Psychological well-being score was found to be Mean=4.95, SD=2.02. For social well-being score was found to be Mean=4.98, SD=1.94. The highest score was for spiritual well-being Mean = 5.32, SD = 2.46.
Conclusion
Influencing quality of life (QoL) is an important issue in Breast cancer patients. Apart from effect of treatment there are other factors like socioeconomic status, psychological well-being, fear of recurrence etc., Which plays a pivotal role in patients wellbeing and if counseled at various levels like family, hospital and society can improve QoL.

Advancement in Ovarian Cancer Treatment

Samta Gupta; Archana Mehta

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 832-838

Epithelial ovarian malignant growth is ordinarily analyzed at a propelled stage. The better current class of chemotherapy treatments result in the high frequency of full reductions, however, the repetition rate is also higher. The infection eventually is a cycle of free moments and repetitive scenes in most cases. Distinctive focused on treatment draws near and natural medications, as of now being worked on, bring the guarantee of transforming ovarian malignant growth into a sensible ceaseless ailment. In this survey, we examine the present standard in the treatment for ovarian malignancy, significant late examinations on the new variations of regular treatments, and new remedial methodologies, as of late endorsed as well as in clinical preliminaries. The following also have an opponent in angiogenic drugs, polyADP-ribose polymerase (PARP), developmental factor flagging inhibitors or folate receptor inhibitors. They also address the cost-effectiveness of certain new treatments and the question of best option for personalized therapy.

LIFE-SAVING ADVANCES IN SKIN CANCER TREATMENT

Yazhlini P; Dr Jayalakshmi Somasundaram

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 350-358

AIM: This study aims to find out about life-saving advances in skin cancer treatment.
INTRODUCTION: Skin malignant diseases are those that emerge from the skin. They are due to the development of abnormal cells that can invade and spread to different parts of the body there are three types of skin cancer- basal cell carcinoma, squamous cell carcinoma and melanomas. Hereditary factors strongly influence the risk factor of skin disease and malignant growth. Basal cell malignant growth develops gradually and can harm the tissue around it, however, it does not spread to distant areas or result in death. Squamous cell skin disease is bound to spread. Melanomas are the most aggressive. Although hereditary variables may have the least impact on skin management growth, most skin cancers are caused due to exposure to UV radiation.
MATERIALS AND METHODS: Review of various scientific literature was done in preparation of the manuscript. Several databases were searched for relevant articles from pub med and Google scholar. Databases of individual journals were searched for keywords such as skin cancer, sunlight on skin cancer, treatment, advances, prevention etc. The exclusion criteria were case reports, review and studies in other languages.
CONCLUSION: From the review, we can know about many recent advances for the cure of cancer. Personalised vaccines, cell therapy, gene editing and micro-treatment are newer technologies for treating cancer. In future cancer can also become a curable disease.

The mechanisms and challenges of cancer chemotherapy resistance: A current overview

Ravindran Ankathil

European Journal of Molecular & Clinical Medicine, 2019, Volume 6, Issue 1, Pages 26-34

Chemotherapy remains one of the principal modes of treatment for cancer patients. Despite advances in anticancer agents for multiple cancers, development of resistance to classical chemotherapeutic drugs and targeted drugs continues to be a major challenge. Drug resistance which can be either intrinsic or acquired, leads to treatment failure and tumor progression. Drug resistance occurs because of mechanisms that are associated with individual cancer cells or through mechanisms that relate to the microenvironment within tumors. Multiple molecular determinants of intrinsic and acquired resistance including genetic, epigenetic factors, as well as other factors which act at the genomic or cellular level have been identified. This review provides a conspectus on some of the recent discoveries on mechanisms of anticancer drug resistance and the possible ways to revert resistance and thereby improve cancer therapy.

Zhengyuan capsule alleviates chemotherapy-related fatigue in nude mice with human lung adenocarcinoma A549 xenografts

Jieshan Guan; Lizhu Lin; Mingzi Ouyang

European Journal of Molecular & Clinical Medicine, 2019, Volume 6, Issue 1, Pages 3-11

Aim: We aimed to investigate the action mechanism of Zhengyuan capsule (a registered proprietary Chinese medicine) against chemotherapy-related fatigue (CRF). Methods: BALB/c-nu nude mice model with human lung adenocarcinoma A549 xenografts was constructed by injection of A549 cell suspension. The xenografted mice were randomly divided into model, cisplatin and cisplatin+Zhengyuan groups (n = 20 each). The cisplatin group was given an intraperitoneal injection of 5 mg/kg cisplatin every 3 days for 21 days. The cisplatin+Zhengyuan group was given an intragastric administration of cisplatin and 25 mg/kg Zhengyuan capsule each day for 21 days. Normal control and model groups were administrated with equal amount of saline. Forced swimming assay, tail suspension test, open field test, hepatic glycogen assay, blood analysis, and bone marrow smear was performed. Results: The cisplatin group developed CRF after receiving chemotherapy. When compared with cisplatin group, the cisplatin+Zhengyuan group exhibited longer exhaustive swimming time (p