European Journal of Molecular & Clinical Medicine

This research article utilizes the finite element method of analysis to achieve
the finest throughput of piezoresistive nano cantilever sensor by minimizing the
dimensions of both physical piezoresistor and cantilever. The
750nmx300nmx15nm-sized cantilever is incorporated with 5nm substantial Si as
piezoresistor is used for revision. The proposed cantilever output performance has
been calculated based onsurface stress sensitivity and displacement. A
maximumresultant displacement value of about 12nm for the load of 100pN has
been obtained . The Performance comparison between Polysilicon and SiO2
cantilever has been found out by applied identical load and measured displacement.
Similarly the sensitivity of the cantilever sensor by parametric sweep on thickness is
applied for both cantilever and piezoresistor. The parametric sweep results shows
that the sensitivity of the cantilever is highest when the thickness of both cantilever
and piezoresistoris at the smallest. Poly silicon and SiO2 based cantilevers with the
built-in longitudinal cut at the bottom create stress concentration regions which will
greatly improved sensitivity as high as 13.89% and 31.81% in comparison with
other Non-SCR cantilevers for the proposed design.

Hepatocyte is the primary functional cell of the liver. More than 80 % of liver is constructed by the hepatocyte cell. Calcium is working as a second messenger. The particular cytosolic Ca2+ level in hepatocyte cell is responsible for frequently working of the liver. In signal transduction calcium play an essential role in hepatocyte cell. Many biological processes are controlled by the calcium like secretion, muscular contraction, cell differentiation, movement of cell, signaling in cell and processes of buffering etc. Diffusion of calcium in the cell is represented by the reaction-diffusion equations. Here two-dimensional model is developed to estimate the effect of the essential biophysical parameters as association coefficient, bound buffer, influx and coefficient of diffusion over profiles of calcium on hepatocyte cell. The aim of the study is to analyze the effect of cytosolic calcium diffusion in hepatocyte cell when the buffer is present in large amount. The results have been used to establish the relationships among various biophysical parameters.