Online ISSN: 2515-8260

Keywords : thyroid-stimulating hormone (TSH)


Dr Md Rashid AhsanLodhi, Dr AsifAyaz, Dr SayantaannSaha, Dr. C. R. Mallikarjuna .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 3105-3108

Background: In endocrinology, the most commonly prevalent and undiagnosed condition encountered is thyroid dysfunction having a high burden on the healthcare sector in India. In addition, Iodine is an essential micronutrient for mental and physical growth in humans, its deficiency remains highly prevalent globally. Thyroid enlargement is commonly associated with thyroid deficiency clinically with decreased iron and selenium levels, and an increase in smoking, natural goitrogen, and TSH levels. Goiter representing enlargement of the entire thyroid gland is seen associated with raised levels of TSH, hyperthyroidism, or hypothyroidism.
Aim: The present clinical study was conducted to assess the association of thyroid hormone levels and goiter by assessing the thyroid profile in subjects with goiter.
Methods:The present cross-sectional study included 200 subjects comprising of 100 subjects with goiter and 100 normal healthy subjects in the age range of 18-35 years. For all the included subjects, thyroid hormone profile and thyroid function tests were assessed.
Results:The study results showed a significant difference between healthy subjects and subjects with goiter in hyperthyroid and hypothyroid subjects. The prevalence of goiter was largely influenced by lower and higher concentrations of TSH.
Conclusion:The present study concludes that the prevalence of goiter largely depends on abnormal and normal levels of Thyroid Stimulating Hormone (TSH) depicting hormonal dysfunction. TSH levels, thyroid nodules, and female gender were found to be the possible predictor for goiter, whereas, thyroid volume, TSH levels, and female gender were found to be predictors for thyroid nodules. Assessment of epidemiological profile is needed to obtain the definitive conclusion.

Detection Of Subclinical Hypothyroidism In Jammu Region And Its Association With Hypercholesterolemia


European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4042-4051

Previous studies showed patients with mild hypothyroidism, mainly elderly women, are at a higher risk of cardiovascular diseases because of lipid abnormalities. This study is conducted to find predominanceof subclinical hypothyroidism in apparently healthy patients and to determine, either hypercholesterolemia is common insubclinical hypothyroidismpatients or inindividuals with euthyroid. This observational study was conducted in Government Medical College, Jammu (Department of Biochemistry) over a period of four months.Biochemical investigations for thyroid function and lipid profile were conducted on 150 patients of either sex, aged 18 to 85 years. Based on serum TSH values, patients were divided into SCH (n=53) and EU group (n=97).
Quantitative variables were calculated and statistical significant result was considered for p-value less than 0.05.TSH valuesfound to be elevated in individuals with subclinical hypothyroidism. Similarly, serum TC and triglyceridesfound significantly elevated in SCH group than in EU group. On perspective of age, average total cholesterol values were elevated in all age-groups of SCH group. This study conclude that in SCH group, there is an increase in levels of atherogenic lipids, especially total cholesterol (TC). Female patients as well as patients with>60 years are pronetohypercholesterolemia, which suggests that all adults above 35 years with subclinical hypothyroidism should be asked to get their lipid profile investigated.