Online ISSN: 2515-8260

Keywords : Alcohol consumption

In India, alcohol consumption is correlated with impaired β-cell function independent of body mass index

Utkal Kishore Khadanga, Madhusmita Mishra

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 11167-11175

Type 2 diabetes is linked to alcohol consumption. The link between alcohol consumption
and β-cell function, on the other hand, is still unknown. The purpose of this study is to
look at the link between them. 675 Indian men between the ages of 20 and 75 were
enlisted. The participants were first categorised into four categories: never drinkers,
abstainers, light drinkers (0.1-19.9 g/day), moderate drinkers (20.0-39.9 g/day), and
heavy drinkers (≥40.0 g/day), and then into two subgroups based on their body mass
index (BMI) (BMI< 25kg/m2 and BMI ≥25kg/m2). Confounders such as age, smoking
status, BMI, waist circumference (WC), blood pressure, lipids, and blood uric acid were
used to adapt the analysis process.Alcohol intake was linked to lower homeostasis model
assessment of β-cell function (HOMA-β) scores when compared to never drinkers,
regardless of BMI. In the BMI<25kg/m2 group, the homeostasis model assessment of
insulin resistance (HOMA-IR) was strongly connected with alcohol consumption
history, and in the BMI≥25kg/m2 group, it was significantly correlated with alcohol
consumption. The findings imply that alcohol intake is linked to β-cell dysfunction in
Indian community-dwelling men, regardless of BMI

A Mini Review On Liver Injuries Among Humans Due To Drugs And Consumption Of Alcohol

Sumaira Yousuf; Mahendra P. Singh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4268-4276

Liver is the most important vital organ that carries out metabolism of body e.g. formation of cholesterol and triglycerides, synthesis of glycogen, formation of blood clotting proteins and bile formation. Hepatic damage and subsequent liver failure due to both unintentional and intentional acetaminophen overdose has afflicted patients for decades and includes the metabolic cornerstone pathways that exist within hepatocytes in the microsomes. The side effects of drugs on the hepatocytes have been overlooked for years. Drug induced liver injury is the most adverse effect observed in clinical practices. It accounts for around half of acute liver disorder. Anti tuberculosis drugs and acetaminophen overdose are the main issues that result in death from curable diseases. Metabolism of isoniazid and acetaminophen (APAP) results in the formation of toxic metabolites that results in the oxidative stress and glutathione (GSH) store depletion leads to hepatocellular necrosis and steatosis. Alcohol consumption is also the most common cause of liver cirrhosis. Liver peroxidation is considered to be the major mechanism of alcohol-induced hepatotoxicity. To overcome this oxidative stress, there is need of antioxidants that can balance the redox homeostasis of liver by lowering the APAP overdose effect. Consumption of natural antioxidants derived as secondary metabolites from plants in the form of polyphenols and flavonoids prevent oxidative stress. Medicinal plants are best remedies used for hepatotoxicity caused due to oxidative stress. They are cost friendly, easily available and have no mutagenic effect. Herbal medicines form important part of traditional healthcare system of India.