Online ISSN: 2515-8260

Keywords : alcohol consumption

Significant endoscopic findings and the probable associated factors in dyspeptic patients: A cross-sectional study conducted in a tertiary care hospital, rural Mandya

Dr. Yamuna VS, Dr. Sachin K, Dr. Selva Rani, Dr. Veena Ghanteppagol, Dr. Ullas Mahesh

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 5, Pages 382-390

Introduction: Dyspepsia is the most common gastrointestinal problem. Majority of dyspepsia is functional dyspepsia. Due to the high prevalence of dyspepsia, inappropriate use of upper GI Endoscopy can lead to unnecessary costs, risk of complications, and associated with reduced diagnostic yield.

To determine the prevalence of significant endoscopic finding (SEF) and H.Pylori in dyspeptic patients.
To determine the response of dyspeptic patients to PPIs and H.pylori eradication therapy.
To assess the factors predicting SEF in dyspeptic patients.

Materials and Methods: This was a cross-sectional study conducted for a period of 18 months among 100 patients with dyspepsia at department of general surgery of a tertiary care hospital. Data was collected using a semi-structured questionnaire by interview technique. The study subjects were subjected to upper gastro-intestinal endoscopy during which biopsies were taken and sent for routine histopathology examination. Descriptive and inferential statistics has been carried out in the present study. A P value < 0.05 was considered statistically significant.
Results: The mean age of the study subjects was 45.13±14.06 years. Pain abdomen was the commonest (82.0%) alarm symptom of dyspepsia and 64.0% of those with dyspepsia were smokers and 61.0% were alcoholics. Overall prevalence of significant endoscopic finding (SEF) was 36.0% and duodenal ulcer (22.0%) was the commonest of all. 71.0% revealed H.pylori infection and at least 90.0% responded well to proton pump inhibitors (PPIs) and triple drug therapy. Among the different factors, bloating or belching was found to be significantly associated with the SEF.
Conclusion: The prevalence of SEF was 36.0% and H.pylori was 71.0%. Most of them i.e. 90.0% responded both clinically and microbiologically to the treatment and bloating or belching was a significant alarm symptom associated with SEF. A trial of proton pump inhibitors (PPIs) and triple drug therapy can be considered before subjecting the patients to the invasive procedure of endoscopy.

In India, alcohol consumption is correlated with impaired β-cell function independent of body mass index

Utkal Kishore Khadanga, Madhusmita Mishra

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 11167-11175

Type 2 diabetes is linked to alcohol consumption. The link between alcohol consumption
and β-cell function, on the other hand, is still unknown. The purpose of this study is to
look at the link between them. 675 Indian men between the ages of 20 and 75 were
enlisted. The participants were first categorised into four categories: never drinkers,
abstainers, light drinkers (0.1-19.9 g/day), moderate drinkers (20.0-39.9 g/day), and
heavy drinkers (≥40.0 g/day), and then into two subgroups based on their body mass
index (BMI) (BMI< 25kg/m2 and BMI ≥25kg/m2). Confounders such as age, smoking
status, BMI, waist circumference (WC), blood pressure, lipids, and blood uric acid were
used to adapt the analysis process.Alcohol intake was linked to lower homeostasis model
assessment of β-cell function (HOMA-β) scores when compared to never drinkers,
regardless of BMI. In the BMI<25kg/m2 group, the homeostasis model assessment of
insulin resistance (HOMA-IR) was strongly connected with alcohol consumption
history, and in the BMI≥25kg/m2 group, it was significantly correlated with alcohol
consumption. The findings imply that alcohol intake is linked to β-cell dysfunction in
Indian community-dwelling men, regardless of BMI

A Mini Review On Liver Injuries Among Humans Due To Drugs And Consumption Of Alcohol

Sumaira Yousuf; Mahendra P. Singh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4268-4276

Liver is the most important vital organ that carries out metabolism of body e.g. formation of cholesterol and triglycerides, synthesis of glycogen, formation of blood clotting proteins and bile formation. Hepatic damage and subsequent liver failure due to both unintentional and intentional acetaminophen overdose has afflicted patients for decades and includes the metabolic cornerstone pathways that exist within hepatocytes in the microsomes. The side effects of drugs on the hepatocytes have been overlooked for years. Drug induced liver injury is the most adverse effect observed in clinical practices. It accounts for around half of acute liver disorder. Anti tuberculosis drugs and acetaminophen overdose are the main issues that result in death from curable diseases. Metabolism of isoniazid and acetaminophen (APAP) results in the formation of toxic metabolites that results in the oxidative stress and glutathione (GSH) store depletion leads to hepatocellular necrosis and steatosis. Alcohol consumption is also the most common cause of liver cirrhosis. Liver peroxidation is considered to be the major mechanism of alcohol-induced hepatotoxicity. To overcome this oxidative stress, there is need of antioxidants that can balance the redox homeostasis of liver by lowering the APAP overdose effect. Consumption of natural antioxidants derived as secondary metabolites from plants in the form of polyphenols and flavonoids prevent oxidative stress. Medicinal plants are best remedies used for hepatotoxicity caused due to oxidative stress. They are cost friendly, easily available and have no mutagenic effect. Herbal medicines form important part of traditional healthcare system of India.