Online ISSN: 2515-8260

Keywords : Chronic pancreatitis


CLINICAL PROFILES AND DIFFERENT MANAGEMENT STRATEGIES OF GIANT PSEUDOCYST OF PANCREAS

Dr. Virendra S Athavale, Dr Prachi V Athavale, Dr Rodda Suma

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 901-910

Chronic collection of amylase rich fluid enclosed in a non-epithelialized wall of collagen or granulation tissue, following after, episode of acute pancreatitis (5-15%), chronic pancreatitis (20 to 40%), trauma. Pancreatic cysts are being diagnosed more frequently because of the increasing usage of imaging techniques. Asymptomatic pseudocysts up to 4cms in diameter can be safely observed and monitored without intervention, but larger and symptomatic pseudocysts require intervention.
Method
The materials for this case series was collected from the patients admitted and diagnosed as pseudocyst of pancreas in our surgical units. All 5 cases have been analyzed for this study during period of 6 months from January 2022 to  June  2022.
Results
Out of 5 cases, for 3 cases open surgery was performed, other 1case was ultrasonography assisted drainage was done and other 1 was conservatively managed according to the clinical presentation and investigations. All the cases are kept for regular follow ups with radiological imaging.
Conclusion
Due to progress in sensitivity and more widespread availability of diagnostic imaging techniques, the incidence of pancreatic pseudocysts seems to be increasing steadily. In the above series the different presentations of pseudocyst of pancreas and different techniques of management was elaborated.

Study Of Single Nucleotide Polymorphism Of Tumour Necrosis Factor Alpha (Tnf-Α) And Its Expression In Chronic Pancreatitis Patients Of Kashmir Valley

Khalid Basheer, Arshid Iqbal Qadri, Gowhar Aziz Bhat, Omar J. Shah .

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 5013-5022

Background: Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory cytokine implicated in the development of chronic pancreatitis (CP). Several researchers have looked at the link between the TNF-α-308 polymorphism and CP, however the findings are still controversial. Hence the present study was undertaken to assess the single nucleotide polymorphisms with the expression of TNF-α in CP patients.
Materials and Methods: In this prospective study, a total of 54 radiologically confirmed, CP patients and 101 healthy controls were studied for polymorphic analysis of TNF-α in the Department of Surgical Gastroenterology SKIMS over a period of two years from April 2014 to April 2016.
Results: The mean age of patients was 35 years with female predominance (55.56%). Majority (50) of patients was having tropical pancreatitis and only 4 had history of alcohol intake. There was no statistically significant relationship between frequencies of mutant TNF-α (308) A allele and the risk of CP in our population. No clinical variable showed significant association with TNF-α (-308) AA genotype. TNF-α expression in serum was significantly more in CP patients (82.035±16.97) than in healthy controls (22.382±63.676), (p<0.0001). We couldn’t find any association with TNF-α expression and clinical variables like age, sex, smoking, alcohol, and diabetes. Also, there was no significant association of TNF α expression in relation to genotype as well.
Conclusion: In conclusion, the current study focuses on the significance of TNF-α levels in CP and identifies it as one of the indicators in the disease's genesis.

GIANT PANCREATIC PSEUDOCYST: A RARE CASE REPORT WITH REVIEW OF LITERATURE

Archana C Buch, Sakshi Garg, Arpana Dharwadkar, Shirish S Chandanwale .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 1778-1784

Giant pancreatic pseudocysts are rare and usually occur as a complication of chronic pancreatitis. A pseudocyst greater than 10 cms in diameter is termed as a giant cyst. Here we present a case of giant pancreatic pseudocyst with a unique presentation along with review of literature. Take home message: Giant pancreatic pseudocyst is rare. The treatment and prognosis depend on size, duration and presentation. Early detection and treatment prevent complications and improves prognosis.

Disorders Of The Immune System And Their Immunological Rehabilitation In Patients With Chronic Pancreatitis

SuleymanovSuleyman Fayzullayevich

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 5178-5187

The immune system studied in 36 patients with chronic pancreatitis (CP) and 32 healthy individuals. In patients with CP showed a deficit of T-lymphocytes and subset tension humoral immunity and cytokine profile: TNF–α, IL–4, IL–6. Using thymoptinum (dose of 0.8-1.0 mg per course) in conjunction with conventional treatment in patients with CP led to an increase in cellular immunity and stabilization of cytokine levels.