Online ISSN: 2515-8260

Keywords : Vitex negundo

In-Vitro Screening of Reverse Transcriptase Activity of Selected Indian Medicinal Plants against Human Immunodeficiency Virus Type-1

Priyadarshini K; Kulandhaivel M; Sankareswaran M; Anbalagan S

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 5168-5175

Human Immunodeficiency Virus type-1 (HIV-1) is that the explanation for Acquired Immune Deficiency Syndrome (AIDS), a serious human viral disease.The high cost of the HAART regimen has impeded its delivery to over 90% of the HIV/AIDS population within the world. The aim of the present study was to evaluate the in vitro anti-HIV activity of selected Indian medicinal plant extracts.Extracts were prepared from dried plant Vitex negundo, Evolvulusalsinoides and Datura metel leaf with Hexane, Methanol, Ethanol, Chloroform, and Petroleum ether. The phytochemical activities and HIV-1 RT inhibition activity (HIV-1 RT colorimetric ELISA kit –Roche Kit method) was carried with the all solvent extracts of Vitex negundo, Evolvulusalsinoides and Datura metelwas determined. The methanolic extracts of Vitex negundo have given the maximum and positive result with 74.76±1.36, which proves that Vitex negundo has a potential antiviral activity against HIV. Phytochemical analysis conducted on the plant extracts revealed the presence of constituents which are known to exhibit medicinal also as physiological activities.The predominant components present altogether the extracts of Vitex negundo are flavonoids, Terpenoids and steroids. Thus this study seems to justify the normal use of plant for the treatment of communicable disease of viral origin.


Nishtha .; Ravneet Kaur

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4459-4462

Plants have proved to a crucial role in human lives due to their immense
beneficial aspects. Plants contain many biochemical substances located in various parts of
their bodies which are termed as phytochemicals. These are also termed as active
secondary products or metabolites that are used to treat many human diseases. Research is
going on large scale whereby plants are examined for their metabolite exudates that
further generate beneficial and assertive outcomes. One such plant is which is being
discussed in this context is Vitex negundo that is also known as ‘Chastetree’. This plant
belongs to Verbenaceae family and has enormous certain chemical active principle
ingredients in its body parts such as alkaloids, flavonoids, terpenes, saponins, lignins and
so on which are basically are obtained from leaves and seeds of this plant. The most
important alkaloid that was worked upon is Nishidine’. The present review paper throws
light upon therapeutic and bioactive phyto compounds that are chemical constituents of
economic and industrial value.