Online ISSN: 2515-8260

Keywords : green chemistry

Bifunctional Thiourea–Amine based Organocatalyst excelling in Multi Component Reactions

Monika Verma; Renu Sharma; Ruchi Bharti

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4529-4542

Recently, exclusive feature of small organic molecules i.e., organocatalysts like low cost,
environment benign, nonmetallic, solubility, stability in normal conditions, easy
availability has made it, a very attractive catalyst to unified diverse fields in synthetic
organic chemistry. Organocatalysts specifically based on thiourea-amine based attained a
great attention among research propagators. These catalysts are capable of activating an
electrophile through hydrogen bond formation and at the same time, activate nucleophile
by involving amine group. In spite of great advantage of this catalyst, a very little work has
been done with it in multicomponent reactions (MCRs). To explore the applications of
these catalysts in MCRs we focused on the utilization of these dual functionalility
containing moieties in MCRs.