Online ISSN: 2515-8260

Keywords : Intubation

Effect of Bacteriophage and Sub-inhibitory concentration of Imipenemon Biofilm Production by Pseudomonas aeruginosa on Endotracheal tubing - An in-vitro model system


European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 1998-2008

Aim: To studybiofilm production by Pseudomonas aeruginosaon endotracheal tubing in the presence of bacteriophage and sub-inhibitory concentration of imipenem.Methods and Results: A total of 20 clinical isolates of P.aeruginosa obtained from endotracheal samples were taken for this study. Bacteriophages were obtained from sewage samples from sewage water treatment plant. Biofilm assay was performed by modified O’Toole and Kolter method wherein a piece of sterile 0.5cm2 ETTwas incorporated into the microtitre plate wells. Student’s unpaired t test, Kruskal Wallis, ANOVA and HSD Tukey’s test were used to analyse data with SPSS 17.0 software. P value of ˂0.05 was considered statistically significant.Of the 20 isolates, only four (20%) of the isolates were resistant to imipenem. In the presence of bacteriophage, the biofilm production was very less in comparison to biofilm production in the presence of sub-inhibitory concentration of imipenem or in plain broth (p = 0.004). Conclusions: Bacteriophages effectively reduced the biofilm production by P. aeruginosa on catheter tip. Significance and Impact:The present study demonstrates the effectiveness of using bacteriophage as a biofilm reducing agent. Further studies are required to prove the use of bacteriophage coated ETT to curb hospital acquired infections


Dr. Chandhini Asokan; Dr. Vijay Ebenezer; Dr. Balakrishnan Ramalingam

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 1844-1853

Airway management is a significant worry in patients with maxillofacial injury, on the grounds that an undermined airway route may prompt demise. There are numerous alternatives accessible, every one has specific signs. As a rule, endotracheal intubation is normally not a feasible choice, but rather nasotracheal intubation and tracheotomies can be performed. These two techniques are known to have difficulties. Two options that can be picked are the submental and submandibular intubation procedures.

Ease of Intubation While Using Macintosh and (Mccoy’s Type) Laryngoscope Blade Undergoing with Anaesthesiology

N.V. Kanase; Saudamini Gandhi; Saurabh R Todi

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 70-73

Various anesthesia devices have been designed to overcome the difficult airway scenario in anesthesia practice. The ease of intubation, timing, and hemodynamic variability between the two groups during intubation are considered as primary results compare. The study was conducted in two groups, each group set aside of 65 patients, named Group A and Group B with normal physical status I-II to endothelial intubation. Determined to perform surgery under anesthesia by consent. This includes simple rigid laryngoscopes for complex fiber-optic incubating devices; However, there is weak evidence to support the superiority of one device over another. McCoy’s blade shows overall minimal haemodynamic response and provides better glottic view and ease of intubation as compared to Macintosh blade.