Online ISSN: 2515-8260

Keywords : Nanoemulsion


NanoemulsionswithIntranasal Delivery:AReview

Dr.Ripudaman Singh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4841-4850

In order to resolve the significant disadvantages in the traditional delivery system, new methods of drug delivery are developed. Nanoemulsion is a nano-sized emulsion developed to further increase the availability of active medicament. These are all the thermodynamically steady isotropic system under which two immiscible fluids are combined with a co-factant as well as surfactant emulsifying agent. Hence, nanoemulsionshave advantage of increasing biovailability by avoiding first pass effect ,low solubility and enzymatic degradation.Through nasal course. the medication can get straightforwardly along the trigeminal nerves and olfactory nerves Nanomedicine comprises of emulsion [mostly oil in water] one surfactant or co-surfactant having size measurements [100nm to 300nm or less] with high surface area. Such nanoemulsions have advantage of effectiveas, non-irritant, non-invasive, compared to conventional drug delivery

PREPARTION AND OPTIMIZATION OF NANOEMULSION FORMULATIONS OF ANTIHYPERTENSIVE DRUG CARVEDILOL

*Kaushal Kumar, *Lakshyaveer Singh Saurabh Mishra, Vimal Kumar Singh

European Journal of Molecular & Clinical Medicine, 2018, Volume 5, Issue 1, Pages 282-290

The aim of the present study was focused on the development of nanoemulsion of carvedilol, an antihypertensive drug, to be administered through oral route. Twelvenanoemulsionformulations of carvedilol containing different oily phases and different proportions of surfactant-Tween 80 and co-surfactant- PEG 400 were prepared by ultrasonication method and after preliminary evaluation four formulations (F1, F2, F3& F4) were selected for further study. Prepared carvedilol containing nanoemulsions were evaluated for-droplet size and shape through Transmission Electron Microscopy, drug contents and in-vitro drug release patterns through dissolution studies. The entrapment efficiency for various formulations was found to be between 61.02±0.231% to 96.57±0.212%. The drug showed better release rate in comparison to conventional dosage form. All the formulations showed better results in terms of stability. Among the four formulations the best results were found with F1 formulation of carvedilol which gave the highest release of drug 31.28±3.46% after 1 hr and 88.41±2.72% after 24 hrs. The droplet size range in optimized formulation F1, F2, F3 and F4 was found to be between 20.76 to 107.38nm. The droplets were uniform and spherical in shape. It can be concluded that for oral administration of carvedilol a better solubility and bioavailability can be achieved by use of nanoemulsion formulation of the drug which otherwise has poor solubility and bioavailability.