Online ISSN: 2515-8260

Keywords : hypersensitivity pneumonitis


To study the role of HRCT & flexible fiberoptic bronchoscopy in diagnosis of interstitial lung disease

Dr. Rahaman Tanzil, Dr. Srikanth Ravoori, Dr. Md. Mateenuddin Saleem

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 3458-3466

Background: High-resolution computed tomography (HRCT) is more sensitive than plain chest radiograph in distinction of ILD (affectability more conspicuous than 90%) and the image illustration of parenchymal peculiarities on HRCT consistently propose a particular course of action of scientific abnormalities.
Aim: To assess the usefulness of HRCT chest and flexible optic bronchoscopy concerning Bronchoalveolar lavage cellular analysis in the diagnosis of interstitial lung disease. Materials and Methods: A prospective observational study was conducted at tertiary hospital in south India. 50 patients who are suspected to have interstitial lung infection by clinical assessment and history with manifestations and signs are assessed with HRCT chest and HRCT affirmed patients are exposed to fiber optic bronchoscopy and bronchoalveolar lavage is performed and their cytological profiles are investigated.
Results: The mean age of the patients was 50.18 years (SD ±14.3), with an age range from 18 to 70years and most of the study subjects were males. Dyspnoea was the most common presenting symptom (90% of patients), followed by cough (84%) and least is dysphagia (6%). In one young female, a cystic pattern was seen on HRCT with multiple diffuse thin-walled cysts which made us to make a diagnosis of LAM.
Conclusion:Thus, HRCT and BAL when combined, help us in making a confident diagnosis of ILD, obviating the need of a lung biopsy which is not feasible in routine practice due to lack of expertise, facilities and patient reluctance in undergoing a biopsy procedure.

Prospective Analysis of Burden of Hypersensitivity Pneumonitis at a Tertiary Care Hospital

Madhurmay, Rajendra Kumar Saini

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 653-656

Background: Establishing whether patients are exposed to a ‘known cause’ is a key
element in both the diagnostic assessment and the subsequent management of
hypersensitivity pneumonitis (HP).
Objective: The aim of the study is to determine the burden of hypersensitivity
pneumonitis at a respiratory center.
Methods: 100 patients had been enrolled to the study. Demographic, clinical,
radiological and aetiological data were collected with a random identification code for
each patient in view of maintaining the confidentiality during data collection.
Results: Out of 100 patients, there were 65 females and 35 males. Mean age of the
population was 55.50 years (SD = 10.50) years. 50 patients were less than 65 years of
which 30 were aged between 45 to 60 years while 20 were aged <5 years.
Conclusion: In general, patients with acute disease, if correctly and timely diagnosed
and treated, have a good prognosis, and patients usually improve. By contrast, patients
with subacute/chronic HP (in particular those with bird fancier’s disease) often
progress to irreversible pulmonary fibrosis and may die within a few years after
diagnosis.

The Intricacies of Hypersensitivity Pneumonitis

Roshmi Ray

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4881-4888

Hypersensitivity pneumonitis is a lung disorder showing inflammation and hypersensitivity reactions specifically, the Type-III and Type-IV ones. The disorder is also termed extrinsic allergic alveolitis. The exact cure of this is still unknown. Only way suggested by the physicians is to avoid the pathogen to re-enter or re-encounter. At chronic stages the steroidal therapy is recommended such as corticosteroid (Prednisolone) with or without some anti-allergic agents depending upon the extent and nature of exposure by a patient to a causative pathogen. Since there are several causative factors and organic dusts, the diagnosis sometimes becomes difficult and the exact cause becomes unknown in various cases. The paper focuses on the exact matter which is lesser known or misinterpreted to be some other respiratory disorder or hypersensitivity disorder. This can be classified into 3 stages. Among these, Acute hypersensitivity pneumonitis is the most widespread whereas the chronic hypersensitivity pneumonitis is developed in nearly 5% of the acute ones.