European Journal of Molecular & Clinical Medicine

Backgroundandobjectives: Colostrum, the first fluid generated by mothers, is distinct in its nutrient quality and non-nutritive bioactive substances that promote survival and good growth. The research analyzes total proteins, triglycerides, immunoglobulin A, lactose, and calcium in normal colostrum with PIH, GDM, and Anaemia individuals in primigravida to see if there are significant alterations. 
Methods:The research was done on lactating mothers from the Deccan College of Medical Science, Hyderabad, India, with their approval. 80 postpartum women involved in the study, 20 as controls and 60 as instances of PIH, anaemia, and GDM. All cases were examined for protein, triglycerides, IgA, lactose, and calcium. SPSS 17.0 was used to analyse the data. Descriptive results are presented as mean and SD of several groups.
Result:Normal blood pressure (controls) was 120+6.5 mm Hg systolic and 79+3.1 mm Hg diastolic without oedema or proteinuria. Haemoglobin is 10.8+0.7g/dl. PLBS=130.7+7.6 and FBS=949.5. (92+14.6 mg/dl) Normal FBS and PLBS OGTT results. 122.5+7.8 mm Hg systolic, 74+6.8 mm Hg diastolic, 40% (8/20) oedema, 70% proteinuria. PIH, anaemia, and GDM diminish protein (p<0.005). PIH and anaemia had higher triglycerides than GDM (p<0.005). GDM exhibited more IgA than anaemia and PIH. GDM has greater mean lactose levels than anaemia, PIH, and the control group. Lactose levels are similar in anaemia and controls. (p<0.005) Anaemia, PIH, and GDM lower calcium.
Conclusion:Human milk contains number of of bioactive substances that fight infection, inflammation, immunological maturation, organ development, and healthy microbial colonisation. Pregnancy hypertension impacts lactogenesis and colostrum content.  Nutrition impacts milk composition. GDM affects pregnant women, mother and infant. Screening, diagnosing, and treating hyperglycemia are critical for mother and child. Regardless of diet, multivitamins are required throughout lactation. The study can't characterise all bioactive human milk components.

Infant mortality rate (IMR) BogorIn 2018 was 5.44 per 1000 live births, an increase compared to 2017 of 3.6 per 1000 live births.life birth which means there was no decrease. Umbilical cord infection has become the cause of pain and death among infants. Indonesia Health Profile 2018 stated that there were 40 babies affected by neonatal tetanus of which 4 babies died. Colostrum can accelerate the process of umbilical cord release through polymorph nuclear leukocytes, proteolysis enzymes and other immunological compounds. There are few bacterial colonies found on the umbilical cord when it is treated with the colostrum method. This research aimto determine the effectiveness of colostrum use to accelerate the release of the umbilical cord among infants in the Mekar Wangi Public Health Center in Bogor City. The study design used in this study was quasi-experimental (Quasi Experiment), using experimental and control groups. The samples in this study were 30 people. The sampling technique used was purposive sampling. The results of the study were obtained using the Independent t test, sig. (2 tailed) 0.008 <0.05. There was an influence of the Colostrum methods on the time of umbilical cord release. It is expected that the institution can facilitate the development of research by increasing the source of books and collaborating with related institutions, and further researchers are expected to develop research related to the colostrum method so that it can be patented as a basic care for newborns