Online ISSN: 2515-8260

Keywords : stroke

Role of Susceptibility-Weighted Imaging Inevaluation of Acute Ischemic Stroke

Bhavani Bangaru, Pilli Srujana, Shaik Ameenulla Hafeezuddin

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10395-10403

Background:Stroke causes mortality and disability. Thrombolytic therapy is standard
for ischemic strokes up to 4.5 h after symptoms. Although artery occlusion can be
diagnosed by DSA, MRA, and CTA, thrombus composition and development
timeframes may not be known. SWI is used to detect thrombus in acute ischemic stroke.
SWI can indicate a thrombus as a hypointense SVS.Wecompared the detection of
hemorrhage by using susceptibility weighted imaging (SWI) with T1, T2 and Fluid
attenuation inversion recovery (FLAIR) sequences in acute stroke.
Materials and Methods: From October 2020 to October 2021, 150 patients with
suspected acute stroke were examined prospectively at Kakatiya Medical College/MGM
Hospital Warangal using the above sequences. Acute infract haemorrhage detection was
evaluated and compared.
Results: In 58 individuals, 48 had arterial infarcts and 10 had venous infarcts.
Hemorrhage affected 38 (25.33%) of 94 male patients and 18 (12%) of 56 female
patients.When compared to T1, T2, and FLAIR, SWI was significantly more sensitive
and specific (p value 0.0031) for detecting haemorrhage in acute infract. There were 26
(17.33%) cases of Susceptibility sign, which indicates an intravascular thrombus.
Conclusion: SWI is the most effective sequence for detecting haemorrhage in acute
infracts. It can also determine the source of an infraction by detecting the susceptibility
sign. The SWI sequence must be included in the protocol for evaluating patients with
acute stroke.

The effect of body mass index (BMI) on the mortality among patients with stroke

Salah Elsayed, Muath Othman

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 181-186

Stroke is considered one of the leading causesof morbidity and mortality in many
countries. Many studies investigated the outcomes after the occurrence of stroke.
Some of those research studies indicated that obesity and the increasein the
bodymass index areestablished risk factors for mortality among stroke patients.
However, the results of these studies were inconsistent.The main aim of this review
article was to examine the association between bodymass index and mortality
among stroke patients. The majority of the studies had shown a possible effect of
overweight on mortality among stroke patients; the evidence regarding the
association's presence is limited.On the other hand, the majority of the studies had
shown a protective effect of obesity (mild obesity, bodymass index between 30-35)
onreducingthe risk of mortality among stroke patients. This means underweight
stroke patients have more risk of mortality. Thus, the argument regarding the effect
of high bodymass index on mortality has been explained by the obesity paradox.
However, most of those studies were observational, and results could be attributed
to the methodological flaw. There is a need to well-designed prospective studies that
to overcome the limitation of the previous studies.

Impact of Non-Invasive and Top-Down Approaches On Hemispatial Neglect in Stroke Patients: A Systematic Review and Meta-Analysis.

Noha A. Nasef; Gehan M. Ahmed; Mahmoud S. El Fakharany; Abdelaziz Abdelaziz Elsherif

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 1293-1305

Aim: One of the most common disorders in stroke is hemispatial neglect. Regarding treatment of hemispatial neglect, there are many physiotherapy interventions including top-down, bottom-up and non-invasive approaches. In this study, we aimed to systemically examine the effect of these approaches in hemispatial neglect patient.



European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 3895-3913

BACKGROUND:One of the leading cause for disability and morbidity in India is Stroke.Among the stroke survivors, Urinary Incontinence (UI) is the most common condition that is more associated to disability and mortality. A study stated that among the continent stroke survivors 35% of them had an incidence of UI in a week.The ―Vagus nerve stimulation‖ is a generalized term describing any method of stimulation of Vagus nerve. OBJECTIVE:To Find out the Effectiveness of Transcutaneous Electrical Nerve Stimulation of Vagus nerve in post stroke urinary incontinence . METHODOLOGY:The study design is experimental,study type was Single Blinded Randomized type, Sampling method was Random sampling Method with 30 subjects and Study duration was 8 weeks,Studysetting was SRM Medical College Hospital and Research Centre, Kattankulathur A total of 30 subjects were taken randomly ,Group-A subjects were given transcutaneous Vagus Nerve Stimulation (tVNS) and Kegel’s exercise. Group-B control group was given Kegel’s exercise alone. OUTCOME MEASURES:Barthel Index Score (BIS) and Overactive Bladder Symptom Score (OBSS) RESULTS: There is a significantly more improvement in the control of urinary bladder in Group-A than Group-B CONCLUSION: tVNS shows an increase in the bladder control in post stroke urinary incontinence patients.

A Smart Neural Schema based Volitional Control for Paralysed People

Dr.SU. Suganthi; G. Valarmathi; K. Sivashankari; V. Subashini; R. Janaki; A. Harshavardhan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 5033-5039

An individual brought into the world paralyzed because of a birth deformity, or incapacitated abruptly because of a stroke or spinal string injury, will be halfway or absolutely unfit to move the influenced body parts. Simultaneously, the individual may encounter muscle firmness and diminished inclination in the influenced body parts. These people depend vigorously on family and parental figures as they can't perform numerous exercises of everyday living. We propose this undertaking utilizing an epic incitement setup and control standards so as to give dependable actuation of the muscles liable for hand developments, a movement control system to invigorate the muscle. So as to activate the muscle we have to secure the EEG signals and its procedure the equivalent. The handled EEG signal is presently used to control and activate muscle when required. This proposed framework concocts answer for an incapacitated people by methods for "mind-controlled" muscle incitement

Evaluation of the effectiveness of acupuncture in the complex treatment of neurological disorders in ischemic stroke

Dilbar T. Khodjieva; Tuxtaev I. Turakulovich; Khaydarov N. Kadirovich

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5780-5783

Taking into account the above, the identification of the possibilities of using acupuncture methods, along with other methods of treating acute cerebrovascular accidents, becomes relevant both from a practical and economic point of view. Intensive therapy, early rehabilitation and prevention of complications, the search for new approaches to treatment will reduce the mortality and disability of patients with this type of pathology

Optimization of the diagnosis and treatment of early neurological complications in cardio embolicstroke

Dilbar T. Khodjieva; Zarnigor . Nurova; Nodir K. Khaydarov; Dildor K. Khaydarova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5788-5792

Acute ischemic damage to neurons during the development of a focus of cerebral infarction (CI) is based on a complex cascade of interaction between the endothelium of the vascular wall, hemostatic factors, neurons and microglia. Oxygen starvation of tissues stimulates the production of endothelial cells of endothelial dysfunction markers produced by blood vessel endotheliocytes, macrophages, neurons and neuroglia in response to hypoxic brain damage. The so-called “cell death genes” are activated, which are responsible for the development of apoptosis, or programmed death of ischemic penumbra cells, as a result of the expansion of which the infarction volume increases

Assessment of Risk Factors For Stroke In The Vertebrobasilar System And Their Impact On Rehabilitation

Bakhadirova Munisa Anvarovna; Mirjuraev Elbek Mirshavkatovich; Shadmanova Lola Abdudjalilovna; Bakhadirova Madina Olimkhanovna

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3100-3115

Relevance: The high prevalence, high risk of social maladjustment as a result of the consequences of acute cerebrovascular accident and, accordingly, one of the main causes of mortality gives cerebrovascular pathology a special status, as evidenced by numerous publications. the task was to identify in the studied patients the entire spectrum of clinical manifestations corresponding to the lesions of the brain structures supplied by the blood vessels of VBD and to determine the presence of a statistically significant dependence of clinical manifestations of COPD. As well as the identification of risk factors and their influence on the rehabilitation of patients with stroke in the vertebrobasilar system.
Patients with IS in VBD and COPD - 62 people (group I) - 29 men and 33 women aged 50 to 74 years (59.8 ± 5.8). Patients with IS in VBD - 64 people (group II). Of these, 31 were men and 33 were women aged 51 to 80 years (62.4 ± 5.4). All patients received traditional treatment in the most acute and acute periods of IS, patients with COPD received COPD treatment in parallel with traditional IS therapy. in group I, BMI averaged 29.3 ± 5.8 kg / m2, in men - 28.9 ± 6.3 kg / m2, in women - 29.9 ± 5.1 kg / m2 (the difference is not significant, p = 0.58), while 11 patients (17.7%) had a normal BMI, 1 patient (1.6%) had a body weight deficit, 26 patients (41.9%) had preobesity, 15 patients (24, 2%) had first degree obesity, 9 patients (14.5%) had second degree obesity. Accordingly, preobesity or obesity was recorded in 50 patients of group I (80.65%) (Figure 3.3)
And in group II, BMI averaged 28.7 ± 6.1 kg / m2, in men - 27.8 ± 5.7 kg / m2, in women - 30.1 ± 5.6 kg / m2 (the difference is not significant, p = 0.6), while 17 patients (26.6%) had a normal BMI, 3 patients (4.7%) were found to be underweight, 29 patients (45.3%) had preobesity, 8 patients (12 , 5%) had first degree obesity, 7 patients (10.9%) had second degree obesity. Accordingly, preobesity or obesity was recorded in 44 patients of group II (68.8%). In patients of group I, among the clinical manifestations of IS in PBS, ataxia prevailed, which occurred in 35 patients (56.5%), including hemiataxia, which occurred in 20 patients (31.3%). Paresis and paralysis of the limbs were detected in 31 patients (50%). Complaints about a subjective feeling of unsteadiness, instability in an upright position, and imbalance occurred in 25 patients (40.3%). Dysarthria also occurred in 25 cases (40.3%). Nystagmus was detected in 22 cases (35.5%), rotational dizziness (vertigo) - in 20 cases (32.3%), depression of consciousness - in 21 cases (33.9%). Symptoms such as hemianopsia and ophthalmoparesis occurred each in 14 cases (22.6%). Sensory disorders were detected in 12 patients (19.4%), autonomic disorders - in 8 patients (12.9%), diplopia - in 8 patients (12.9%), dysphagia - in 7 patients (11.3%) , aphasia and headache - 6 patients each (9.7% each), dysphonia - 7 patients (11.3%), confusion and visual agnosia - 4 patients each (6.5% each), respiratory failure - 3 patients (4.8%). There were also 2 cases (3.2% each) of amnesia, ignorance syndrome and a feeling of generalized weakness.

Optimization Of Neuroprotective Therapy Of Ischemic Stroke In The Acute Period

Khaydarova Dildora Kadirovna; Khodjyeva Dilbar Tadjiyevna; Bobokulov Gulmurod Dilmurodovich

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3720-3723

The problem of cerebrovascular diseases and stroke is significant not only for clinical neurology, but also for society as a whole. Stroke is the second most common cause of death in many developed countries. In Russia, more than 450 thousand cases of this disease are registered per year, and in the Republic of Uzbekistan there are more than ten thousand cases, the mortality rate in the acute period of stroke in Russia reaches 35%, increasing by another 12-15% by the end of the first year after the stroke. Stroke ranks first among the causes of persistent disability, which necessitates timely drug therapy not only in the acute period of the disease, but also throughout the recovery phase.

Concurrent effects of attentional focus on postural sway during quiet standing in chronic stroke patients

Sang Heon Jeong; Byoung Sun Chu; Young Uk Ryu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 4017-4025

The purpose of this study was to investigate the effects of attentional focus on static postural control in chronic stroke patients. Twenty four subjects diagnosed with chronic stroke participated in the experiment. All subjects maintained quiet standing on a force plate for 30 s with three attentional focus conditions: baseline (BL), internal focus (IF), andexternal focus (EF). No instructions regarding attentional focus were given to the subjects for the BL condition. The subjects were instructed to stand with their attention focused on their feet for the IF condition. Under the EF condition, the subjects were first instructed to check red markers indicated on the force plate. Then the subjects were asked to look front but to concentrate on the markers. The results demonstrated that the EF condition reduced the amount and instability of postural sway more than the other attentional focus conditions. The effects of attentional focus on postural sway were only exhibited in the mediolateral direction. This study suggests that directing attention focused on the movement effect that occurs in the external environment around the body may help stroke patients enhance the postural control of quiet standing.This might result from reduced asymmetric weight distribution with external focus. The present results provide a possible use of external focus to stabilize static posture in physical therapy for patients with stroke.

Steering Accuracy and Sitting Symmetry During Simulated Driving in Drivers with Chronic Stroke

Hwa-Kyung Shin; Young Uk Ryu; Ho-Cheol Lee

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 3988-3994

The steering while sitting in the driver's seat is one of the most basic and important driving performances. The purpose of this study was to investigate the characteristics of sitting symmetry and steering accuracy of stroke drivers compared to healthy drivers, and to examine the correlation between them.Fifteen stroke drivers and fifteen healthy drivers participated in this study. Both group performed the large and small s-curve driving during five minute. Accuracy index (AI) was measured by comparing the performance line that drove along large s-curve and small s-curve (target line). Symmetry index (SI) was calculated by difference of right and left seat pressure.The steering AI of stroke drivers was significantly lower than that of healthy adult drivers (p <0.05), and the AI of small S-curves was significantly lower than that of large S-curves (p <0.05). The sitting SI of stroke drivers was significantly greater than that of healthy driver (p <0.05). Also, AI of stroke driver showed significant correlation with SI in both S-curve. However, healthy drivers had no significant correlation between SI and AI (p> 0.05). SI and AI are valid variables for evaluating the stroke driver's driving ability in off-road environment.

Serum Uric Acid Level and Severity of Ischemic Stroke

Aparna P. Patange; Kapale R.J.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 86-89

A stroke is the third most common cause of death and the fourth most common cause of infection. Stroke is characterized by the WHO as a clinical condition involving the rapid development of clinical indications of a central aggravation of cerebral capacity lasting more than 24 hours or causing death without a clear reason other than a vascular source. In the present study, a large part of the cases of intense ischemic stroke were found among the males. In the present study, mean cholesterol values, triglyceride values are directly proportional to the severity of the ischemic stroke, among the study subjects. In the present study, 8% cases died, while 92% discharged at home. The current study proved the association of serum uric acid levels with the severity of the acute ischemic stroke.