Online ISSN: 2515-8260

Keywords : serum


Dr. Madupathi Anil Babu, Dr. Brungi Ashajyothi, Dr. Tatikonda Karuna Sree, Dr. Abhigna Sai

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 552-568

Background: Pregnancy-related hypertensive disorders, a condition with numerous maternal and foetal consequences, can be avoided. By measuring serum uric acid levels, the condition can be detected early on and its progression can be stopped. In India, the prevalence of PIH varies from 5% to 15%. Fetal growth restriction, low birth weight, spontaneous or iatrogenic premature delivery, respiratory distress syndrome, and admission to neonatal intensive care are all significantly linked to preeclampsia. Preeclampsia prediction may aid in classifying women into high risk groups so that surveillance can be stepped up and preventative treatments can be started.
Aim and Objectives: The purpose of this research is to investigate the role that serum uric acid plays as a predictive factor in hypertensive disorders of pregnancy. The purpose of this study is to determine the function that serum uric acid plays in the determination of hypertensive problems in pregnancy. The purpose of this study is to evaluate the accuracy of blood uric acid as a potential predictive predictor of maternal and foetal problems related with hypertensive diseases of pregnancy.
Methods: Patients with hypertensive disorders of pregnancy who came in for antenatal checkups between 24-32 weeks and had blood pressure readings of more than or equal to 140/90 mmHg but did not have proteinuria were included in a study that was conducted in the department of obstetrics and gynaecology at the Modern government maternity hospital in Petlaburz. The inclusion and exclusion criteria were met by these patients. As part of the standard evaluation, the level of uric acid in the serum was determined for each and every hypertensive patient. Recording was done for both the maternal and perinatal outcomes.
Results: In the current study, 46 (46%) of the 100 women with HDP had elevated serum uric acid levels. Of the 64 women who had pre-eclampsia, 34 (53.1%) had high serum uric acid levels. The median serum uric acid level was 6.2mg/dl, with an SD of 1.8. Numerous maternal and postnatal problems, including eclampsia, abruption of the placenta, HELLP syndrome, and foetal growth restriction, were linked to hyperuricemia in HDP patients.
Conclusion: Patients who have been given a diagnosis of hypertensive disorders of pregnancy and who also have hyperuricemia are at an increased risk for a variety of different maternal and perinatal complications.

A Study of association of serum magnesium and zinc levels in diabetics

Dr. Ramesh Dnyanadeo

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1316-1320

Background: Hypomagnesaemia and hypermagnesuria was reported to be associated with diabetes complications. Thus, magnesium has drawn considerable attention for its potential role in improving insulin sensitivity and preventing DM. Zinc, another important trace element, acting as a cofactor for several biochemical processes has a major role in health status. There is substantiating evidence indicating the importance of zinc in DM. Impaired zinc metabolism, decreased plasma zinc and hyperzincuria has been reported as a consequential effect of glucose absorption. But limited studies have been conducted in this part of the world. This study puts in an effort to find the answers.
Aims and Objectives: To study the association of serum magnesium and zinc levels in diabetics.
Materials and Methods: This study was done in the Department of General Medicine, SSPM’S Medical College and Lifetime Hospital, Padve.
This study was done from Jan 2019 to Dec 2020.
Ninety and an equal age and sex matched control were used for the study.
Results: There is a strong association between the serum magnesium and zinc levels in diabetics when compared to normal individuals.
Conclusion: More number of studies have to come up in different geographical locations so as to be helpful to the practicing physicians.

Significance of Serum Samples for Protein Studies

Pushpalakshmi Gangadharan; Ananthi Sivagnanam; Balasankar Thangasamy; Ambika Pushparaj; Premkumar Karunakaran; Raja JeyaSekar R; Megala Jayaraman; Pushparaj Arunachalam

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 740-749

Serum proteins also known as blood or plasma proteins are proteins present in
blood that serve many different functions, including transport of lipids, hormones,
vitamins, and minerals in the circulatory system and the regulation of acellular activity
and functioning of the immune system. Other blood proteins act as enzymes, complement
components, protease inhibitors, or kinin precursors. Although serum proteins have very
high concentrations, they exhibit an uneven distribution in terms of composition. That is,
only about 22 proteins account for 99% of all the serum proteins. These include serum
albumin, globulins, and fibrinogen. The remainder 1% of blood proteins is composed of
low abundance circulatory proteins, as well as proteins secreted by live, apoptotic, and
necrotic cells. Most blood proteins are secreted by the liver and intestines except for the
gamma globulins, which are synthesized by the immune system. In this study we aimed to
analyse the serum samples taken from gastric cancer patients and compared with healthy
serum samples. We estimated the serum samples using Bradford method of protein
estimation and performed SDS PAGE analysis. This article highlights the importance of
serum sample collection, handling and storage with respect to consideration towards
protein-based studies using serum samples.

Serum Uric Acid Level and Severity of Ischemic Stroke

Aparna P. Patange; Kapale R.J.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 86-89

A stroke is the third most common cause of death and the fourth most common cause of infection. Stroke is characterized by the WHO as a clinical condition involving the rapid development of clinical indications of a central aggravation of cerebral capacity lasting more than 24 hours or causing death without a clear reason other than a vascular source. In the present study, a large part of the cases of intense ischemic stroke were found among the males. In the present study, mean cholesterol values, triglyceride values are directly proportional to the severity of the ischemic stroke, among the study subjects. In the present study, 8% cases died, while 92% discharged at home. The current study proved the association of serum uric acid levels with the severity of the acute ischemic stroke.

Characteristics Of Exchange Of Essential Microelements Of Copper And Zinc In Healthy Fertilized Women And Women With Combined Copper And Zinc Deficiency State

Sohibova Ziyoda Rakhmonovna; Akhmedova Nilufar Sharipovna

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 3332-3335

The study of various aspects of the problem of common hypomicroelementosis caused by a deficiency of essential trace elements copper and zinc, in particular among women of fertile age, in the population is extremely relevant and important, taking into account the social significance and importance of this population for society , because of what the condition will be health in a given population depends on the state of such important socially significant processes as the healthy development of future generations