Online ISSN: 2515-8260

Keywords : Uric acid


The Association between Uric and Ascorbial Acid Serum and Lichen Planus Pathogenesis

Sara Mohamed Mohamed; Sahar Mohamed Abd El fattah; El-Sayed Mohamed Galal; HodaAbdeen Ibrahim

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 489-494

Background: Lichen planus (LP) is a common disorder whose etiopathogenesis is not clear.Recently, it has been suggested that increased reactive oxygen species (ROS) play important roles in the underlying mechanism of LP. Free radicals have an important involvement in the underlying mechanism of lichen planus and also various skin diseases. The aim of the study was to evaluate serum uric acid (UA) levels as a measure of the antioxidant defense status in lichen planus patients.
Methods: A case control study was performed on 17 patients with lichen planus and 17 healthy subjects as a control group. We estimated Serum level of uric acid and ascorbic acid using ELISA.
Results: The mean of serum levels of uric acid and ascorbic acid was lower in patient group compared to healthy group with no significant difference between the two studied groups.
Conclusion: Lichen planus pathogens are not specifically affected by antioxidants as uric acid and ascorbic acid. However, in addition to other interactive variables, the difference in the level of serum for these anti-oxidants between lichen planus patients and healthy subjectsalbight not important– may suggest their involvement.

“Evaluating Salivary pH, Uric acid, & CReactive Protein levels in Completely Edentulous patients before and after wearing Complete dentures incorporated with and without 7.5% Chitosan nanoparticles” – An Interventional Study

DR ADITYA SONAWANE; DR. SEEMA SATHE KAMBALA MDS

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2132-2137

Abstract: Background: Saliva plays major part in oral well-being of complete denture
users and also considered a very important biomarker for overall body health and indicates
several biomolecules just like blood to give useful information and monitoring of diseases
and health .Denture stomatitis is a common finding in complete denture wearers and
analysing salivary ph, Uric acid & C-reactive protein levels through saliva collection will
help in its early diagnosis and treatment. Chitosan, a biomaterial nanoparticle
incorporated into dentures gives it antifungal and antimicrobial effect. Having
antimicrobial and regenerative properties it is of interest in dentistry and already being
used in toothpastes, mouth rinses and dental dressings.
Objectives: To evaluate salivary ph , Uric acid & C-Reactive protein levels before and after
complete denture insertion with and without addition of Chitosan nanoparticles &
Comparatively evaluate the outcome.
Method: 15 complete denture patients incorporated with Chitosan nanoparticles will be
tested for salivary ph, C-Reactive protein & Uric acid levels. Saliva samples will be
collected from subjects immediately before the insertion of complete dentures and after 24
hrs and compared with Control groups not containing Chitosan.
Results: This study shows antifungal and antimicrobial effect of Chitosan in Complete
dentures which implies less fungal activity post denture insertion leading to less denture
stomatitis cases proving effectiveness in preventing Denture stomatitis.

Comparative Study of Xanthine Oxidase Inhibitory Activity Of Methanolic Leaf Extracts Of CalophyllumBlancoi (Bitaog), Diospyrospilosanthera (Bolongeta) and Syzygium Cumini (Duhat)

Jan Asuncion; Mariane May Domingo; Rave Harvey Sienna; Zhaine Marille Villa; Jennifer Anne Loyola

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 4077-4086

Gout is characterized as an inflammation and warmth in the joints. It is associated with hyperuricemia wherein an upregulation of xanthine oxidase in purine degradation leads to increased levels of uric acid in the blood. Gout is not fatal. However, it affects one’s quality of life. Thus, this research primarily focuses in determining the inhibitory activity of xanthine oxidase in the methanolic leaf extract of bitaog (Calophyllumblancoi), bolongeta (Diospyros pilosanthera), and duhat (Syzygiumcumini) in gout. A quantitative-experimental research method was used in the study and the data were obtained by measuring the percent inhibition of the samples using UV-Vis spectrophotometer at 290 nm. The results showed that the methanolic leaf extract of above stated plants exhibited exemplary inhibition in comparison with the standard drug, allopurinol. The IC50 value determines the ability of the inhibitor to decrease the biotransformation of a substrate. The principle behind IC50 is, the lower the value the higher the inhibition. The bitaog (Calophyllumblancoi) trials have the lowest IC50 value with an average of 124.3 after the standard drug, followed by bolongeta (Diospyros pilosanthera) have an average of 155.3 IC50 value. Then duhat (Syzygiumcumini) showed the highest IC50 an average of 208.8.The bitaog (Calophyllumblancoi), next to allopurinol, showed the highest inhibition among all the extracts followed by the bolongeta (Diospyros pilosanthera). The least inhibitory activity was observed in duhat (Syzygiumcumini). Hence, it can be concluded that bitaog (Calophyllumblancoi), bolongeta (Diospyros pilosanthera), and duhat (Syzygiumcumini) can inhibit xanthine oxidase using in vitro analysis

The Importance Of Uric Acid Level In Patients With Persistent Kidney Disease Of Predialysis Stages

Dano A. Egamberdieva; Botir T. Daminov; Iroda A. Ruzmetova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3417-3429

The study explores theory of relativity of acid levels with nephritic function, moreover as its role as a prognostic marker of cardio tube risk in chronic excretory organ diseases within the course of variable regression analysis, taking into consideration the adjustment of potential risk issues, the amount of uric acid was found to be a major factor influencing calculable capillary vessel filtration rate. The results of this study showed that elevated humor uric acid levels are related to the next risk of kidney malfunction.

Effect Of Endovascular Revascularization On Renal Function

Botir T. Daminov; B.A. Alyvi; Shavkat K. Muminov; Lola T. Daminova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3444-3453

To research the short-term and long-term effect of coronary artery stenting on renal function. In patients with coronary heart disease within 3 months after endovascular revascularization-preserving renal dysfunction, despite the normalization of creatinine concentration.

Serum Uric Acid Level and Severity of Ischemic Stroke

Aparna P. Patange; Kapale R.J.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 86-89

A stroke is the third most common cause of death and the fourth most common cause of infection. Stroke is characterized by the WHO as a clinical condition involving the rapid development of clinical indications of a central aggravation of cerebral capacity lasting more than 24 hours or causing death without a clear reason other than a vascular source. In the present study, a large part of the cases of intense ischemic stroke were found among the males. In the present study, mean cholesterol values, triglyceride values are directly proportional to the severity of the ischemic stroke, among the study subjects. In the present study, 8% cases died, while 92% discharged at home. The current study proved the association of serum uric acid levels with the severity of the acute ischemic stroke.